Effect of atropine on the bronchial response of asthmatic subjects to the inhalation of ultrasonically nebulized distilled water

Fabbri, Leonardo M.; Hendrick, D. J.; Diem, John E.

doi:10.1016/0091-6749(83)90463-3

Cited by 15 publications

(2 citation statements)

References 14 publications

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“…The anticholinergic agents have been shown to be inconsistent in their effect and changes in baseline FEY 1 due to their action as bronchodilators make the fmdings difficult to inteiJJret [114,118,119]. The sensitivity to hypertonic saline is reduced with daily administration of corticosteroids given as aerosols [120].…”

Section: 2mentioning

confidence: 99%

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

et al. 1993

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Section: 2mentioning

confidence: 99%

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

et al. 1993

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“…This abnormal cholinergic hyper-sensitivity of an asthmatic's airways is highlighted by the bronchoconstrictive response to doses of inhaled cholinergic agents (acetylcholine and methacholine) that do not affect normal subjects. Moreover, anticholinergic drugs such as atropine have demonstrated some protective effects from bronchoconstriction induced by different non specific stimuli (histamine, cold air, ultrasonically nebulized distilled water) [9,10] and a partial inhibition of immediate airway response to allergen [11]. For all of these reasons, cholinergic antagonists have been tested as potential drugs for the treatment of obstructive airway diseases.…”

Section: Monaldi Arch Chest Dis 2013; 79: 3-4 109-115mentioning

confidence: 99%

Tiotropium: a new therapeutic option in asthma

Novelli

Costa

Latorre

et al. 2013

Monaldi Arch Chest Dis

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Although bronchial hyperresponsiveness to cholinergic agents is a main feature of asthma, the role of anticholinergic drugs in chronic asthma management has been largely underestimated. Several single-dose studies comparing acute bronchodilation induced by ipratropium bromide with salbutamol have shown that salbutamol is more effective than ipratropium in treating asthma. Recently, tiotropium has been studied in asthma, when added to low-medium dose inhaled corticosteroids (ICS) in unselected moderate asthmatics or in patients with uncontrolled asthma, or with COPD and history of asthma. Later, studies on patients with Arg/Arg beta2-receptor polymorphism demonstrated a similar efficacy of tiotropium in comparison with salmeterol, when both were added to ICS. More recently, pivotal long-term studies have been performed on severe asthmatics uncontrolled under ICS/LABA combination, showing the efficacy of tiotropium in improving lung function and in increasing the time until the first severe asthma exacerbation. These data support the use of tiotropium on top of ICS/LABA combination in moderate-severe asthmatic patients. New studies are going to be published on the use of tiotropium in mild and moderate asthmatics, when added to low or medium dose ICS, in comparison with ICS alone or with ICS/LABA combination. These data might extend the indication for using tiotropium in asthma. Therefore, tiotropium represents now a valid therapeutic option, in addition to the current therapy available for severe asthmatics, and in alternative to LABA in selected asthma populations. The specific asthma phenotype which may be appropriate for tiotropium treatment should still be defined.

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Determination of airway hyper‐reactivity in asthmatic children: A comparison among exercise, nebulized water, and histamine challenge

Fourie

Joubert

1988

Pediatric Pulmonology

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An easy and accurate method of assessing bronchial hyper-reactivity could be of great value in identifying and classifying the degree of severity of asthma in children. The sensitivity and specificity of three methods of provocation, ie, histamine, nebulized water, and exercise, were compared in 20 asthmatic and 20 control children between ages 5 and 13 years. Three clinical categories of severity ranging from slight (Group 1) through moderate (Group 2) to severe asthma (Group 3) were identified. The three methods were compared in each subgroup for detecting a tendency to bronchospasm. An inverse correlation (-0.57) was found between the histamine dose and clinical degree of severity, whereas distilled water and exercise proved to be too insensitive for identifying Group 1 asthmatics. Histamine challenge in children is a safe and sensitive technique for identifying asthma and for monitoring the severity of the disease during follow-up.

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Effect of atropine on the bronchial response of asthmatic subjects to the inhalation of ultrasonically nebulized distilled water

Cited by 15 publications

References 14 publications

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

Tiotropium: a new therapeutic option in asthma

Determination of airway hyper‐reactivity in asthmatic children: A comparison among exercise, nebulized water, and histamine challenge

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