Effect of attention bias modification on event‐related potentials in patients with irritable bowel syndrome: A preliminary brain function and psycho‐behavioral study

Tayama, Jun; Saigo, Tatsuo; Ogawa, S.; Takeoka, Atsushi; Hamaguchi, Toyohiro; Inoue, Kenji; Okamura, Hisayoshi; Yajima, Jumpei; Matsudaira, Ko; Fukudo, Shin; Shirabe, Susumu

doi:10.1111/nmo.13402

Cited by 7 publications

(3 citation statements)

References 61 publications

(124 reference statements)

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“…Neuroimaging studies support this assumption by demonstrating increased functional connectivity in the salience network in IBS patients during resting state (83), rectal stimulation (84) and contextual threat situations (85). Initial support that the behavioral modification of attentional bias may improve attentional functioning and regulation of brain mechanisms related to anxiety and attention in IBS patients (86,87), provides a treatment perspective to complement more basic mechanistic research.…”

Section: Discussionmentioning

confidence: 95%

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model

2020

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Although the broad role of fear and hypervigilance in conditions of the gut-brain axis like irritable bowel syndrome is supported by converging evidence, the underlying mechanisms remain incompletely understood. Even in healthy individuals, it remains unclear how pain-related fear may contribute to pain-related attentional biases for acute visceral pain. Building on our classical fear conditioning work in a clinically relevant model of visceral pain, we herein elucidated pain-related attentional biases shaped by associative learning in healthy women and men, aiming to elucidate possible sex differences and the role of psychological traits. To this end, we compared the impact of differentially conditioned pain-predictive cues on attentional biases in healthy women and men. Sixty-four volunteers accomplished a visual dot-probe task and subsequently underwent pain-related fear conditioning where one visual cue (CS + ) was contingently paired with a painful rectal distention (US) while another cue remained unpaired (CS − ). During the following test phase, the dot-probe task was repeated to investigate changes in attentional biases in response to differentially valenced cues. While pain-related learning was comparable between groups, men revealed more pronounced attentional engagement with the CS + and CS − whereas women demonstrated stronger difficulties to disengage from the CS + when presented with a neutral cue. However, when both CS + and CS − were presented together, women revealed stronger difficulties to disengage from the CS − . Regression analyses revealed an interaction of sex, with negative affect predicting stronger avoidance of the CS + and stronger difficulties to disengage attention from the CS − in men. These results provide first evidence that pain-related fear conditioning may induce attentional biases differentially in healthy women and men. Hence, sex differences may play a role in attentional mechanisms underlying hypervigilance, and may be modulated by psychological vulnerability factors relevant to chronic visceral pain.

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Section: Discussionmentioning

confidence: 95%

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model

2020

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“…Conversely, ABM training away from threat has also been found to enhance cue‐locked P1 amplitudes (Dennis‐Tiwary et al., 2016). Finally, in a sample of individuals with irritable bowel syndrome (IBS), ABM training away from threat lead to decreased P1 latencies for probes (Tayama et al., 2018). Taken together, the literature suggests that ABM can influence the early visual sensory processing associated with the P1 component.…”

Section: Effect Of Abm On Erpsmentioning

confidence: 99%

A systematic review of event‐related potentials as outcome measures of attention bias modification

Carlson

2021

Psychophysiology

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| BACKGROUND AND RATIONALE 1.1 | Attention bias and attention bias modification Attention bias modification (ABM) was introduced nearly two decades ago as a method of modifying (i.e., increasing or decreasing) attentional biases or preferences (MacLeod et al., 2002;Mathews & MacLeod, 2002). Attentional bias arises due to the limited processing capacity of the brain. Humans are unable to process all sensory information equally and accordingly must selectively prioritize a subset of sensory inputs (Desimone & Duncan, 1995). Emotional salience-and in particular threat-relevance-is one way in which sensory information is prioritized (Ohman et al., 2001;Vuilleumier, 2005). An attentional bias to threat, therefore, refers to the preferential allocation of attentional resources to threatening stimuli relative to nonthreatening stimuli. Attention bias can be directly measured with psychophysiological measures such as event-related potentials (ERPs) or indirectly through reaction time (RT) measures . This review focuses on the usage of ERPs as outcome measures of ABM training, both as measures of attentional bias as well as measures of more distant cognitive processes influenced by ABM.

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“…16 With respect to IBS patients, trust as a specific construct is even more important than communication, as suggested by the various psychological implications of response to a placebo, personality traits, depression, and anxiety. [17][18][19][20][21][22][23][24][25][26][27][28][29] Previous studies suggest that trusting one's gastroenterologist is of paramount importance. This is true because sub-populations with particular phenotypes might require different approaches to diagnosis and treatment, 30 or they might trust their doctor less because of a high level of anxiety.…”

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confidence: 99%

A comparison using standardized measures for patients with irritable bowel syndrome: Trust in the gastroenterologist and reliance on the internet

Rotaru

Frățilă

Bărboi

et al. 2020

Neurogastroenterology Motil

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A patient's trust in their doctor is important for an effective doctor-patient relationship. [1][2][3][4] However, trust is a dynamic interaction.Therefore, it is difficult to measure. However, some researchers have developed scales broadly measuring a patient's trust in their doctor in general. [5][6][7][8] These previous scales targeted a patient's trust in their doctor for other specialties than gastroenterology 9-14 or a patient's satisfaction. 15 To date, questionnaires evaluating the doctorpatient relationship in irritable bowel syndrome (IBS) include only

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Effect of attention bias modification on event‐related potentials in patients with irritable bowel syndrome: A preliminary brain function and psycho‐behavioral study

Abstract: Attention bias modification may have clinical utility for normalizing brain function and specifically attentional abnormalities in patients with IBS.

Cited by 7 publications

References 61 publications

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model

Sex Differences Linking Pain-Related Fear and Interoceptive Hypervigilance: Attentional Biases to Conditioned Threat and Safety Signals in a Visceral Pain Model

A systematic review of event‐related potentials as outcome measures of attention bias modification

A comparison using standardized measures for patients with irritable bowel syndrome: Trust in the gastroenterologist and reliance on the internet

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