“…While these data do not reveal what is causing the increases and decreases in rates or elasticity, one hypothesis is that the impact of supply side policy interventions such as establishment of prescription drug monitoring programs (PDMP), increased law enforcement ( Dowell et al, 2016 , National Alliance for Model State Drug Laws, 2016 , Rutkow et al, 2015 , Office of National Drug Control Policy, 2018 ), drug take back programs ( Gray and Hagemeier, 2012 , Fass, 2011 ), and dose limit laws may be underlying factors ( Barth et al, 2017 , Davis et al, 2018 Nov 3 , National Conference of State Legislators, 2018 ). Previous research indicates that these approaches may have a moderate effect (3.0–5.3% reduction) on fatal opioid overdose ( Bao et al, 2016 , Brady et al, 2014 , Moyo et al, 2017 , Yarbrough, 2018 , Wen et al, 2017 , Sun et al, 2018 , Haffajee et al, 2018 ). However, it is unclear what the effect of these interventions may have been on fatal overdose rates.…”