Effect of azelaic acid on melanoma cells in culture

Lemic-Stojcevic, L.; Nias, A. H. W.; Breathnach, A. S.

doi:10.1111/j.1600-0625.1995.tb00226.x

Cited by 25 publications

(21 citation statements)

References 8 publications

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“…Melanin inhibition in melanoma cells [132]. Clinical study on patients with facial hyperpigmentation showed an improvement in pigment intensity by one or more grades [133].…”

Section: Azelaic Acidmentioning

confidence: 99%

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

Gillbro¹,

Olsson²

2011

Intern J of Cosmetic Sci

317

251

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SynopsisSkin-lightening products are commercially available for cosmetic purposes to obtain lighter skin complexion. Clinically, they are also used for treatment of hyperpigmentary disorders such as melasma, café au lait spot and solar lentigo. All of these target naturally melanin production, and many of the commonly used agents are known as competitive inhibitors of tyrosinase, one of the key enzymes in melanogenesis. In this review, we present an overview of commonly used skin-whitening ingredients that are commercialized, but we also hypothesize on other mechanisms that could be important targets to control skin pigmentation such as for example regulation of the adrenergic and glutaminergic signalling and also control of tetrahydrobiopterins in the human skin. Ré suméLes produits éclaircissants sont disponibles dans le commerce pour des buts cosmétiques afin d'obtenir un tient plus clair. Ils sont égale-ment utilisés en clinique, pour le traitement de troubles hyper pigmentaires comme le melasma, les taches café au lait et le lentigo solaire. Tous ces produits ont pour cible la production naturelle de mélanine et beaucoup de ceux généralement utilisés sont reconnus comme des inhibiteurs compétitifs de la tyrosinase, une des enzymes clés de la mélanogénèse. Dans cette revue, nous présentons une vue d'ensemble des ingrédients généralement utilisés et commercialisés comme blanchissant cutanés mais nous formulons aussi l'hypothèse que d'autres mécanismes pourraient être des cibles importantes pour contrôler la pigmentation de la peau comme par exemple la régula-tion du signal adrénergique et glutaminergique ou le contrôle des tetrahydrobiopterines dans la peau humaine.

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“…Melanin inhibition in melanoma cells [132]. Clinical study on patients with facial hyperpigmentation showed an improvement in pigment intensity by one or more grades [133].…”

Section: Azelaic Acidmentioning

confidence: 99%

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

Gillbro¹,

Olsson²

2011

Intern J of Cosmetic Sci

317

251

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“…The substances that have a pigment inhibitory effect in the hyperpigmented lesions include retinoid, kojic acid, arbutin, hydroquinone, pentadecenoic acid, oleanolic acid, ursodeoxycholic acid, vitamin C, catechol, phenol, medimin C, and pinellia ternata extract 19 . Drugs that act by both suppression of melanocytes proliferation and melanogenesis include 4-isopropylcatechol, 4-hydroxyanisole, hydroquinone, monobenzylether of hydroquinone, monoethylether of hydroquinone, and azelaic acid [20][21][22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

“…It was revealed that topical application of 0.2% phytoclear-EL1 on human skin had a similar inhibitory effect of pigmentation as the positive control (3% arbutin). Recently, the combined use of hydroquinone, azelaic acid, and retinoic acid has been reported to be effective in inducing a pigment inhibitory effect 8,20 . Thus, applying phytoclear-EL1 with arbutin, kajic acid, and retinoic acid is thought to be effective and presents an interesting area for continued research.…”

Section: Discussionmentioning

confidence: 99%

The Inhibitory Effect of Phytoclear-EL1 on Melanogenesis

et al. 2009

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Background: Phytoclear-EL1, an extract from Euphorbia lathyris seeds, has a whitening effect due to inhibition of tyrosinase activity. Objective: The purpose of this study was to investigate the inhibitory effect of phytoclear-EL1 on melanogenesis. Methods: Cultured B-16 melanoma cells and 30 human volunteers were used for in vitro and in vivo studies, respectively. Phytoclear-EL1 was added to the cultured B-16 melanoma cells, and applied to UVB-induced hyperpigmented lesions of human volunteers twice daily for 7 weeks. Changes in the number of B-16 melanoma cells, as well as changes in morphology, melanin content, and tyrosinase activity, were measured and then compared with the normal control and the 10 −3 M arbutin groups. Also, the effect of phytoclear-EL1 on UVB-induced hyperpigmented lesions was examined through subjective and objective measurements. Results: In the in vitro study (p＜0.05), the number, melanin content, and tyrosinase activity of cultured B-16 melanoma cells were decreased in the 5μg/ml phytoclear-EL1 group compared to the control group. On objective assessment with a chromameter, the 0.2% phytoclear-EL1 group had a larger difference in the mean L values before and 7 weeks after applying phytoclear-EL1 as compared to the other groups. On subjective assessment by both the researchers and subjects 7 weeks after applying experimental materials, the 0.2% phytoclear-EL1 group and positive control (3% arbutin) had higher scores than the placebo groups. These results demonstrated that phytoclear-EL1 in vivo and in vitro had an inhibitory effect on melano-

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“…AzA can block tyrosinase activity by competitive inhibition [67,68,69,70,71]. AzA is also reported to have an inhibitory effect on DNA synthesis in melanoma cell lines [71,72].…”

Section: Influence Of Aza On Melanogenesismentioning

confidence: 99%

Azelaic Acid: Properties and Mode of Action

Sieber

Hegel²

2013

Skin Pharmacol Physiol

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Acne is a common skin disorder that can be problematic for adults as well as for adolescents. It has several key pathophysiological features such as follicular hyperkeratosis, elevated Propionibacterium acnes proliferation, and reactive inflammation, all of which should be targeted for an optimal outcome. Azelaic acid (AzA) has profound anti-inflammatory, antioxidative effects, and is bactericidal against a range of Gram-negative and Gram-positive microorganisms as well, including antibiotic-resistant bacterial strains. In addition, AzA's antikeratinizing effects are inhibitory toward comedones. AzA is effective overall in targeting multiple causes of acne and has been proven to be well tolerated in numerous clinical trials.

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Effect of azelaic acid on melanoma cells in culture

Cited by 25 publications

References 8 publications

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

The Inhibitory Effect of Phytoclear-EL1 on Melanogenesis

Azelaic Acid: Properties and Mode of Action

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