Effect of Azelastine, an Antiasthmatic Drug, on Bronchial Responsiveness in Patients with Bronchial Asthma

Iwata, Masaru; Tano, Masao; Sugiyama, Satoru; Taki, Fumio; Satake, Tatsuo

doi:10.1378/chest.95.6.1231

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…Although antihistamine monotherapy does not influence BHR to methacholine,22 23 and only has a small bronchodilator effect,24 a reduction in both nasal and asthma symptoms was recently reported in two large multicentre trials of the effects of antihistamines on seasonal asthma 2526 Additional treatment with antihistamines may influence the lower airways either directly or by an improvement in nasal function, and may account for the inconsistent observations of the effects of intranasal steroids on BHR in the literature.…”

Section: Discussionmentioning

confidence: 99%

Influence of intranasal steroids during the grass pollen season on bronchial responsiveness in children and young adults with asthma and hay fever

Thio

2000

Thorax

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Background-It has been reported that intranasal corticosteroids can influence bronchial hyperresponsiveness (BHR) in asthmatic subjects with seasonal rhinitis. The purpose of the present study was to evaluate the eVect of intranasal fluticasone propionate and beclomethasone dipropionate on BHR and bronchial calibre (forced expiratory volume in one second, FEV 1 ) in children and young adults with seasonal rhinitis and mild asthma during two consecutive grass pollen seasons. Conclusions-Intranasal steroids did not influence BHR during two grass pollen seasons in children and young adults with seasonal rhinitis and mild asthma. (Thorax 2000;55:826-832) Methods-In

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Section: Discussionmentioning

confidence: 99%

Influence of intranasal steroids during the grass pollen season on bronchial responsiveness in children and young adults with asthma and hay fever

Thio

2000

Thorax

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“…Antiallergic drugs such as disodi um cromoglycate [4], azelastine [5] and ketotifen [6] arc well known to have favorable effects on asthma. Beneficial effects of these drugs are considered to be dependent par tially on anti-inflammatory actions on airway inflamma tions [7], Several studies have shown that macrolide anti biotics such as erythromycin and troleandromycin can fa vorably influence the clinical status of certain patients with asthma [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antiasthmatic Activity of a Macrolide Antibiotic, Roxithromycin: Analysis of Possible Mechanisms in vitro and in vivo

Konno¹,

Asano

Kurokawa³

et al. 1994

Int Arch Allergy Immunol

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This study was designed to examine the possible mechanisms by which macrolide antibiotics favorably influence the clinical course of asthmatic patients. In the first set of experiments, we investigated the effect of roxithromycin (RXM), a newly synthesized macrolide antibiotic, on in vitro cytokine secretion by mitogen-activated human peripheral blood leukocytes. RXM suppressed the secretion of T cell cytokine interleukins (IL) 2-4 and monocyte cytokine tumor necrosis factor alpha. This inhibitory effects on cytokine secretion was dose dependent and firstly noted at a concentration of as little as 0.5 μg/ml which is much lower than therapeutic blood levels. In the second part of experiments, we examined the influence of RXM on cytokine appearance in mouse lung extract induced by lipopolysaccharide (LPS) inhalation and on bronchial responsiveness to methacholine in LPS-treated mice. As compared with mice pretreated with phosphate-buffered saline, RXM administred orally at a single dose of 5 mg/kg once a day for 21 days inhibited the appearance of IL-3, IL-4, IL-5, and tumor necrosis factor alpha in aqueous lung extracts. Pretreatment with RXM also decreased the bronchial responsiveness to methacholine induced by intratracheal injection of LPS. We conclude that the attenuating effect of macrolide antibiotics on asthmatic syndromes might be explained partially by their inhibitory effects on cytokine secretion from leukocytes.

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Effects of azelastine on contraction of guinea pig tracheal smooth muscle

Lee

Ohya

Doupnik

et al. 1990

European Journal of Pharmacology

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Effect of Azelastine, an Antiasthmatic Drug, on Bronchial Responsiveness in Patients with Bronchial Asthma

Cited by 11 publications

References 22 publications

Influence of intranasal steroids during the grass pollen season on bronchial responsiveness in children and young adults with asthma and hay fever

Influence of intranasal steroids during the grass pollen season on bronchial responsiveness in children and young adults with asthma and hay fever

Antiasthmatic Activity of a Macrolide Antibiotic, Roxithromycin: Analysis of Possible Mechanisms in vitro and in vivo

Effects of azelastine on contraction of guinea pig tracheal smooth muscle

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