Effect of Azithromycin on Acute Inflammatory Lesions and Colonic Bacterial Load in a Murine Model of Experimental Colitis

Abstract

We documented the anti-inflammatory effect of azithromycin in a murine model of acute colitis, suggesting that effects were targeted to oxidative burst and on mucosal/bacterial interface, independent of luminal bacterial load. Further studies should be focused on effect of azithromycin on the role of bacterial biofilm in perpetuation of chronic intestinal inflammation.

Thermography in surveillance of ulcerative colitis — Case report

“…Dysregulation of the immune reaction leads to excessive activation of pro-inflammatory cytokines. Ethiopathogenetic factors for loss of tolerance to normal host microbiota and subsequent chronic inflammatory cascade include multifactor genetic predisposition that can lead to abnormal epithelial barrier and altered mucosal immune defenses [4][5][6]. Genetic factors play an important role, as shown by epidemiological studies on monozygotic twins.…”

Estudo do potencial imunomodulador de Dehidroepiandrosterona (DHEA) na inflamação intestinal experimental

“…Os animais com inflamação intestinal que receberam ou não tratamento com DHEA e DSS foram avaliados quanto à presença de sinais clínicos da doença como diarreia, ânus molhado, piloereção, hipoatividade e sangramento retal, durante o período de indução da doença (6 dias) e na fase de reparo tecidual (15 dias)(Yan, Kolachala et al 2009, Plesko, Banic et al 2010, Sales-Campos, de Souza et al 2015). Para esta avaliação, foi utilizado um critério de pontuação, no qual cada sinal apresentado pelo animal correspondeu a 1 ponto.…”