It is well known that the mechanical properties of commercial pure Al are influenced by size of α-Al dendrites. In the present work, Al-5Ti-0.62C-0.2Nd grain refiner was prepared by a pure molten aluminum thermal explosion reaction, and its effect on grain refinement and mechanical properties of commercial pure Al was investigated. Microstructure and phase composition show that Al-5Ti-0.62C-0.2Nd grain refiner consists of α-Al, granular TiC, lump-like TiAl 3 , and block-like Ti 2 Al 20 Nd. Grain-refining tests on commercial pure Al show that an Al-5Ti-0.62C-0.2Nd grain refiner has better refining performance compared with Al-5Ti-0.62C grain refiner. With addition of 0.2-wt.%-Al-5Ti-0.62C-0.2Nd grain refiner, the average grain size of commercial pure Al can be refined from roughly 2800 to 155±5 µm effectively, and it has higher resistance to grain-refinement fading. On account of the grain refinement, the tensile strength and elongation are increased by approximately 18.3% and 83.5%, respectively.