Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study

Haggarty, Paul; McCallum, H.; McBain, Hayley; Andrews, K.; Duthie, Susan J.; McNeill, Geraldine; Templeton, Allan; Haites, Neva Elizabeth; Campbell, Doris M.; Bhattacharya, Siladitya

doi:10.1016/s0140-6736(06)68651-0

Cited by 144 publications

(126 citation statements)

References 20 publications

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“…5,10-methylenetetrahydrofolate reductase (MTHFR) and solute carrier family 19, member 1 (SLC19A1)) involved in folate metabolism (Altmäe et al 2010). Mild hyperhomocysteinaemia is prevalent in subjects polymorphic for a number of enzymes involved in folate/methionine metabolism (Midttun et al 2007), and total homocysteine concentrations, measured in follicular fluid, are sensitive to dietary intakes of folic acid (Boxmeer et al 2008) and are associated with pregnancy outcome in clinical IVF cycles (Haggarty et al 2006, Pacchiarotti et al 2007.…”

Section: Introductionmentioning

confidence: 99%

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Kwong¹,

Adamiak²,

Gwynn³

et al. 2010

Reproduction

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Maternal B-vitamin status at conception can affect fertility and the health of offspring. This study details transcript expression for genes encoding key enzymes in the linked methionine/folate cycles in the bovine oocyte, somatic cells of the ovarian follicle and pre-implantation embryo. Transcripts for all 12 enzymes that were studied and for the two folate receptors (FOLR1 and FOLR2) and reduced folate carrier (SLC19A1) were expressed in liver cells, but transcripts for betaine-homocysteine methyltransferase and methionine adenosyl transferase 1A were absent in all ovarian cells, and transcripts for FOLR2 were absent in embryonic cells. Transcripts for glycine methyltransferase were also absent/weak in cumulus and granulosa cells. The absence of these enzymes could have a profound effect on single-carbon metabolism within the ovary and pre-implantation embryo. Immunocytochemical analysis revealed SLC19A1 protein expression on the plasma and basal-lateral membranes of the pre-implantation embryo. The folate antagonist methotrexate (MTX) enters the cell via SLC19A1, and in the current study, MTX inclusion in bovine/ovine culture media at either 1 or 10 mM from the 1-cell stage inhibited embryo development beyond the 8-cell stage. Hypoxanthine and thymidine (100 mM) increased the proportion of embryos that developed to blastocysts, but the cell number was reduced by 20%. The reduced uptake of [ 35 S] methionine into intra-cellular S-adenosylmethionine and S-adenosylhomocysteine pools, together with reduced uptake of glutamate and tryptophan, was consistent with depleted intra-cellular pools of reduced folates. These data provide an insight into the importance of maternal dietary folate/B-vitamin status during the peri-conceptional period.Reproduction (2010) 139 705-715

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Section: Introductionmentioning

confidence: 99%

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Kwong¹,

Adamiak²,

Gwynn³

et al. 2010

Reproduction

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“…In that study, the dose-response association between injected vitamin B 12 and levels of biomarkers was not estimated. (58) Only data on biomarkers Monsen et al (2006) (59) Does not address any relationships of interest Casanueva et al (2006) (60) Type of intervention: multivitamin supplement Choudhry et al (1972) (61) Study design: intervention but not RCT Cikot et al (2001) (62) Only data on biomarkers Couto et al (2007) (63) Only data on biomarkers Cornel et al (2005) (64) Irrelevant micronutrient Czeizel and Dudas (1992) (65) Type of intervention: multi-vitamin supplement Czeizel and Medveczky (2003) (66) Does not address any relationships of interest Dagnelie et al (1989) (67) Does not address any relationships of interest Dawson et al (2000) (68) Study design: intervention but not RCT van Dusseldorp et al (1999) (69) Study design: case-control study Eilander et al (2010) (70) Study design: cross-sectional study investigating S-H relationship Gomber et al (2003) (71) Study design: cross-sectional study investigating S-H relationship Gomber et al (1998) (72) Study design: cross-sectional study investigating S-H relationship Gordon and Carson (1976) (73) Study design: case report Graham et al (1992) (74) Population group: infants did not meet the inclusion criteria (unhealthy) Haggarty et al (2006) (75) Irrelevant health outcome (76) Type of intervention: multi-vitamin supplement …”

Section: Infantsmentioning

confidence: 99%

Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Iglesia¹,

Dhonukshe-Rutten²,

Bel‐Serrat³

et al. 2012

Public Health Nutr.

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Objective: To review evidence on the associations between vitamin B 12 intake and its biomarkers, vitamin B 12 intake and its functional health outcomes, and vitamin B 12 biomarkers and functional health outcomes. Design: A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review. Setting: Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3). Subjects: Population groups included healthy infants, children and adolescents, and pregnant and lactating women. Results: From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women. Conclusions: Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B 12 intake and serum vitamin B 12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B 12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B 12 in young populations.

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“…There is also evidence that the normal MTHFR genotype is related to the ability to produce good quality embryos. This is a result of a prospective study to evaluate vitamin B12, folate and MTHFR gene mutation and their influence on the success of IVF programs (Haggarty, 2006). The ovarian hyperstimulation syndrome (OHS) is a complication of ovulation induction in assisted reproduction treatment.…”

Section: Thrombophilia and Infertilitymentioning

confidence: 99%

“…Because of the success rate of 34%, the assisted reproduction clinics try to improve the pregnancy rate by transferring more than one embryo. This procedure has as a consequence, another problem of great significance and social impact, which is the multiple pregnancy (Haggarty, 2006). Recently, a hypothesis has been raised that the same factors associated with the occurrence of recurrent pregnancy loss may also affect the early phase of the embryo implantation process (Vaquero et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Infertility and Inherited Thrombophilia

Barini¹,

Soligo²,

Annichino-Bizzachi³

et al. 2011

Thrombophilia

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Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study

Cited by 144 publications

References 20 publications

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Infertility and Inherited Thrombophilia

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Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study

Cited by 144 publications

References 20 publications

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo

Association between vitamin B12intake and EURRECA's prioritized biomarkers of vitamin B12in young populations: a systematic review

Infertility and Inherited Thrombophilia

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Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review