Effect of Background Liver Cirrhosis on Outcomes of Hepatectomy for Hepatocellular Carcinoma

Sasaki, Kazunari; Shindoh, Junichi; Margonis, Georgios Antonios; Nishioka, Yujiro; Andreatos, Nikolaos; Sekine, Akinari; Hashimoto, Masaji; Pawlik, Timothy M.

doi:10.1001/jamasurg.2016.5059

Cited by 94 publications

(84 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the operation time was longer in the narrow RM group than in the wide RM group because parenchymal transection is more difficult in cirrhotic liver, and postoperative bile leakage was more frequent in the narrow RM group. As previously reported, the patients with cirrhotic liver experienced postoperative de novo recurrence because of higher carcinogenic potential [36, 37]. In this study, cirrhotic liver was related with disease recurrence with marginal significance in all patients.…”

Section: Discussionsupporting

confidence: 63%

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma

et al. 2018

View full text Add to dashboard Cite

Background: The relationship between resection margin (RM) and recurrence of resected hepatocellular carcinoma (HCC) is unclear. Methods: We reviewed clinical data for 419 patients with HCC. The oncologic outcomes were compared between 2 groups of patients classified according to the inflexion point of the restricted cubic spline plot. Results: The patients were divided according to an RM of <1 cm (n = 233; narrow RM group) or ≥1 cm (n = 186; wide RM group). The 5-year recurrence-free survival (RFS) rate was lower (34.8 vs. 43.8%, p = 0.042) and recurrence near the resection site was more frequent (4.7 vs. 0%, p = 0.010) in the narrow RM group. Patients with multiple lesions, or prior transarterial chemoembolization (TACE) or radiofrequency ablation (RFA) were excluded from subgroup analyses. In patients with a 2–5 cm HCC, the 5-year RFS was greater in the wide RM group (54.4 vs. 32.5%, p = 0.036). Narrow RM (hazard ratio 1.750, 95% CI 1.029–2.976, p = 0.039) was independently associated with disease recurrence. Conclusion: In patients with a single 2–5 cm HCC without prior TACE/RFA, an RM of ≥1 cm was associated with lower risk of recurrence after liver resection.

show abstract

Section: Discussionsupporting

confidence: 63%

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Additionally, despite intending to include Child-Pugh A and early B patients in the study (as indicated in the methods section), the final data includes only patients with class A. Lastly, in this study, around 25% of patients, though suspected to have cirrhosis, did not meet histologic criteria on final pathological examination. This finding could potentially affect the results of the study, as recent data suggest that cirrhosis was associated with poorer prognosis, in part due to higher hepatocarcinogenic potential among these patients (4). Taken together, findings from this work confirm prior data demonstrating the safety of laparoscopy in patients with Child-Pugh class A associated HCC.…”

Section: Editorialsupporting

confidence: 83%

Laparoscopic hepatectomy for hepatocellular carcinoma: are oncologic outcomes truly superior to an open approach?

Moris

Burkhart

Beal

et al. 2017

Hepatobiliary Surg. Nutr.

Self Cite

View full text Add to dashboard Cite

“…For patients with HCC receiving curative resection, ETR usually leads to poor prognosis . Various clinicopathological risk factors, especially portal vascular invasion, have been demonstrated to be significantly correlated with ETR . In this study, GAM analysis enabled us to reveal that tumour size, serum AFP level and the mRNA expression levels of KLB , FGF19 and CCND1 were significantly associated with ETR.…”

Section: Discussionmentioning

confidence: 84%

Klotho‐beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma

Lin

Hsu

Jeng

et al. 2019

Liver International

View full text Add to dashboard Cite

Background and Aims Fibroblast growth factor 19 (FGF19) and fibroblast growth factor receptor 4 (FGFR4) signalling play critical roles in hepatocarcinogenesis. This study explored the potential of FGF19‐ and FGFR4‐related biomarkers in predicting early tumour recurrence (ETR) and survival in patients with resectable hepatocellular carcinoma (HCC). Methods We examined the mRNA expressions of FGF19, FGFR4, klotho‐beta (KLB), cyclin D1 (CCND1) and FGF4 in 151 surgically resected, primary unifocal HCCs through quantitative real‐time polymerase chain reaction. Generalized additive models were fitted to detect nonlinear effects of continuous covariates and define thresholds of biomarker expressions. Univariate and multivariate analyses were performed to evaluate prognostic values of these biomarkers for tumour recurrence and patient survival. Results Overexpression of FGF19, FGFR4, KLB, CCND1 and FGF4 mRNA was detected in 40%, 32%, 26%, 15% and 35% of 151 tumours respectively. ETR was the strongest prognostic factor predicting worse overall survival (hazard ratio [HR], 5.678; 95% confidence interval, 3.7‐8.713; P < 0.001). Furthermore, we revealed that mRNA expression levels of KLB (HR, 3.857; P = 0.021) and FGF19 (HR, 3.248; P = 0.017) were significantly associated with the occurrence of ETR. Conclusions Frequent overexpression of FGF19/FGFR4‐related biomarkers was detected in resectable HCC. Expression levels of KLB and FGF19 may determine patient survival outcomes through their effects on ETR.

show abstract

Effect of Background Liver Cirrhosis on Outcomes of Hepatectomy for Hepatocellular Carcinoma

Cited by 94 publications

References 33 publications

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma

Laparoscopic hepatectomy for hepatocellular carcinoma: are oncologic outcomes truly superior to an open approach?

Klotho‐beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma

Contact Info

Product

Resources

About