Effect of Baduanjin exercise on cerebral blood flow and cognitive frailty in the community older adults with cognitive frailty: A randomized controlled trial

Lin, Hung-Ru; Ye, Yu; Wan, Mingyue; Qiu, Pingting; Xia, Rui; Zheng, Guohua

doi:10.1016/j.jesf.2022.12.001

Cited by 10 publications

(23 citation statements)

References 48 publications

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“…The characteristics of the fifteen articles are shown in Table 2 . There were three multi-paper interventions: two articles reported on different brain function outcomes from the one intervention (Zhu et al, 2018 ; Qi et al, 2019 ), two papers reported on the same intervention outcomes at different time-points (Suo et al, 2016 for intervention effects; Broadhouse et al, 2020 for follow-up), and two publications reported on different aspects of the same brain function measure from the one intervention (Tao et al, 2019 ; Lin et al, 2023 ). As we were interested in intervention effects here, the follow-up findings from Broadhouse et al were excluded from further analysis, but are reported in Table 2 for interested readers.…”

Section: Resultsmentioning

confidence: 99%

Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis

Karamacoska,

Butt,

Leung

et al. 2023

Front. Neurosci.

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IntroductionExercise is recognized as a modifiable lifestyle factor that can mitigate cognitive decline and dementia risk. While the benefits of exercise on cognitive aging have been reported on extensively, neuronal effects in adults experiencing cognitive decline have not been systematically synthesized. The aim of this systematic review was to assess the effects of exercise on cognition and brain function in people with cognitive decline associated with dementia risk.MethodA systematic search was conducted for randomized controlled trials of ≥ 4 weeks exercise (aerobic, resistance, or mind-body) that assessed cognition and brain function using neuroimaging and neurophysiological measures in people with subjective or objective cognitive decline. Study characteristics and brain function effects were narratively synthesized, while domain-specific cognitive performance was subjected to meta-analysis. Study quality was also assessed.Results5,204 records were identified and 12 unique trials met the eligibility criteria, representing 646 adults classified with cognitive frailty, mild or vascular cognitive impairment. Most interventions involved 40-minute sessions conducted 3 times/week. Exercise improved global cognition (g = −0.417, 95% CI, −0.694 to −0.140, p = 0.003, I2 = 43.56%), executive function (g = −0.391, 95% CI, −0.651 to −0.131, p = 0.003, I2 = 13.28%), but not processing speed or general short-term memory (both p >0.05). Across fMRI and ERP studies, significant neuronal adaptations were found with exercise cf. control throughout the brain and were linked with improved global cognition, memory, and executive function. Cerebral blood flow was also found to improve with 24 weeks of exercise, but was not linked with cognitive changes.DiscussionThe cognitive improvements associated with exercise are likely driven by increased metabolic activity, cerebrovascular mechanisms, and neuroplasticity throughout the brain. Our paper shows the promise in, and need for, high-quality trials integrating cognitive and brain function measures to elucidate the functional relationship between exercise and brain health in populations with a high risk of dementia.Systematic review registrationPROSPERO, identifier: CRD42022291843.

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Section: Resultsmentioning

confidence: 99%

Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis

Karamacoska,

Butt,

Leung

et al. 2023

Front. Neurosci.

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“…These findings are consistent with those of previous studies in older adults with physical frailty or cognitive frailty. [23][24][25] As mentioned above, executive function is a set of high-level cognitive processes and typically includes three subdomains/subcomponents (i.e. working memory, inhibitory control and cognitive flexibility).…”

Section: Discussionmentioning

confidence: 99%

“…These findings are consistent with those of previous studies in older adults with physical frailty or cognitive frailty. 23–25…”

Section: Discussionmentioning

confidence: 99%

Effect of Baduanjin exercise on executive function in older adults with cognitive frailty: A randomized controlled trial

Wang,

Wu,

Zhang

et al. 2023

Clin Rehabil

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Objective To investigate the effectiveness of Baduanjin exercise on executive function in community-dwelling older adults with cognitive frailty. Design Randomized controlled trial. Setting Community residential centers. Subjects 120 eligible older adults. Interventions Baduanjin training group received supervised Baduanjin training, 60 min sessions three times per week for 24 weeks. The control group did not receive any exercise intervention. Main measures Primary outcome was executive function, assessed using Clock Drawing Test. Secondary outcomes included the subcomponents of executive function (working memory, inhibitory control and cognitive flexibility), attention and cognitive frailty (global cognitive function, physical frailty) assessed using Verbal Fluency Test, Trail Making Test-A/B, Stroop Test, Montreal Cognitive Assessment and Edmonton Frailty Scale, respectively, at baseline and 24 weeks after intervention. Results After the 24-week intervention, the scores of Clock Drawing Test and Verbal Fluency Test, the Trail Making Test-B time and the Card correct numbers of Stroop Test in Baduanjin training group showed significant improvement compared with control group (all P < 0.05) with small to moderate effect sizes and the significant interaction effect of group by time in the Clock Drawing Test and Trail Making Test-B test ( P = 0.003 and P = 0.043); cognitive frailty variables, including Montreal Cognitive Assessment and Edmonton Frail Scale scores, also showed significant improvement ( P = 0.002 and P = 0.004) with a moderate effect sizes and a significant interaction effect ( P < 0.001, P = 0.013). No adverse events were reported. Conclusion Regular Baduanjin training may be an effective and safe intervention to improve cognitive frailty and executive function in community-dwelling older adults with cognitive frailty. Trial registration Chinese Clinical Trial Registry, ChiCTR2100050857. Data of registration: 8/5/2020, https://www.chictr.org.cn/showproj.html?proj = 133037 .

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“…Currently, exercise interventions are widely considered to be the most important and effective interventions for cognitive frailty in the elderly 30 . Aerobic exercise, Baduanjin exercise, Otago exercise, and diverse integrative exercise have all been shown to delay and reverse cognitive frailty by improving patients' motor and cognitive functions 31–33 . Exercise interventions can improve patients' muscle status by reducing their C‐reactive protein, reducing inflammation, improving their myocyte growth, and increasing muscle strength and endurance 34 .…”

Section: Discussionmentioning

confidence: 99%

“…30 Aerobic exercise, Baduanjin exercise, Otago exercise, and diverse integrative exercise have all been shown to delay and reverse cognitive frailty by improving patients' motor and cognitive functions. [31][32][33] Exercise interventions can improve patients' muscle status by reducing their C-reactive protein, reducing inflammation, improving their myocyte growth, and increasing muscle strength and endurance. 34 Exercise also affects structural plasticity in subregions of the hippocampus, such as the left parietal tract, right angular gyrus 1, and anterior inferior tract, which play a very important role in cognition, thus improving cognitive function.…”

Section: Analysis Of Factors Influencing Cognitive Frailty In Elderly...mentioning

confidence: 99%

Risk factors of cognitive frailty in elderly chronic obstructive pulmonary disease patients and its implication for death: a cohort study

Wu,

Huang,

Jiang

et al. 2023

Psychogeriatrics

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BackgroundsCognitive frailty, a clinical syndrome with physical frailty and cognitive impairment, leads to mortality and other adverse health outcomes in older adults. This study aimed to investigate the prevalence of cognitive frailty, and its influencing factors, and follow its impact on short‐term mortality in elderly chronic obstructive pulmonary disease patients, to provide a theoretical scientific reference basis for clinical intervention and management of cognitive frailty.MethodsA sample of 243 elderly chronic obstructive pulmonary disease patients in the respiratory department of a tertiary care hospital was conveniently sampled from November 2021 to February 2023, and the prevalence of cognitive frailty was investigated using the General Information Survey Scale, the Fried Phenotype Scale, the Mini‐Mental State Examination, the Anxiety Self‐Rating Scale, the Brief Geriatric Depression Scale, and the Mortality Record. The mortality was recorded by telephone follow‐up after 6 months. A database was created and statistical analysis such as one‐way analysis of variance, logistic regression analysis, Kaplan–Meier, and Cox survival analysis were used to analyze the data.ResultsA total of 47 patients (19.3%) had cognitive frailty; there were statistical differences in the prevalence of cognitive frailty by medical payment type, physical exercise, and sleeping time (P < 0.05). During a 6‐month follow‐up, 38 patients (15.6%) died. Cox survival analysis showed that the risk of death in elderly chronic obstructive pulmonary disease patients in the cognitive frailty group was 3.212 times higher than that in the normal cognitive function and non‐frailty group (95% CI 1.646–6.270, P = 0.001), and 5.266 times higher than that in the normal cognitive function and frailty group (95% CI 3.159–8.778, P < 0.001).ConclusionsThe prevalence of cognitive frailty in elderly chronic obstructive pulmonary disease patients is high, and clinical staff should pay attention to patients' medical burden and financial ability, and reduce the incidence of cognitive frailty by instructing patients to perform physical exercise and arrange sleep time. Cognitive frailty is an important risk factor for mortality within 6 months in elderly chronic obstructive pulmonary disease patients, and early intervention should be emphasised to reduce or delay cognitive frailty and mortality.

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Effect of Baduanjin exercise on cerebral blood flow and cognitive frailty in the community older adults with cognitive frailty: A randomized controlled trial

Cited by 10 publications

References 48 publications

Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis

Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis

Effect of Baduanjin exercise on executive function in older adults with cognitive frailty: A randomized controlled trial

Risk factors of cognitive frailty in elderly chronic obstructive pulmonary disease patients and its implication for death: a cohort study

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