Effect of balloon occluded arterial infusion of anticancer drugs on the prognosis of cervical cancer treated with radiation therapy

Tsuji, Ken-ichi; Yamada, Ryusaku; Kawabata, M.; Mitsuzane, K; Sato, Morio; Iwahashi, M; Kitayama, Shunya; Nakano, Ryoko

doi:10.1016/0360-3016(94)00651-z

Cited by 19 publications

(11 citation statements)

References 18 publications

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“…The balloon catheters are then advanced until they reach the vicinity of the feeder vessel (usually the uterine artery), where the balloon is inflated to interrupt the local blood flow. Cis-diamminedichloro-platinum (CDDP) is then slowly infused intra-arterially through the two catheters over a period of 30 min (36). In the present study, the two ovarian arteries were blocked after the first round of BOAI to increase the intratumor concentration of CDDP.…”

Section: Balloon-occluded Arterial Infusion Chemotherapy (Boai)mentioning

confidence: 96%

“…Pelvic angiography was performed under local anesthesia using Seldinger's technique (36) to localize the tumor and feeder vessels. The procedure involves the insertion of a balloon-wedge-single-pressure catheter (5 F, 80 cm in length; Dispomedica, Hamburg, Germany) into each femoral artery, which is then passed into the internal iliac artery.…”

Section: Balloon-occluded Arterial Infusion Chemotherapy (Boai)mentioning

confidence: 99%

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Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

Morishita

Sumi

Nakano

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. We previously reported satisfactory therapeutic results when using cisplatin-based cyclic balloon-occluded arterial infusion chemotherapy as neoadjuvant chemotherapy (NAC), which enabled hysterectomy to be performed for patients with locally advanced cervical cancer. Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. The expression of MAD2 is associated with tumor progression and resistance to chemotherapy. Therefore, the aim of the present study was to examine whether the expression of MAD2 is related to the efficacy of NAC for locally advanced uterine cervical cancer. We reviewed 53 cases of locally advanced uterine cervical cancer (stage IIIa-IIIb; based on the International Federation of Gynecology and Obstetrics criteria). These patients were initially treated at Osaka City University Medical School Hospital, Japan, from 1995 to 2008 and were under 70 years old. Tumor samples were obtained by biopsy prior to NAC. Cases were divided into two groups: one group in which NAC was effective, surgery was possible and radiotherapy was performed (NAC+OP+R group; n=33), and another group in which NAC was ineffective and radiation therapy was performed (NAC+R group; n=20). MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method. The results showed that MAD2 expression was significantly higher in the NAC+R group compared to the NAC+OP+R group (P<0.001). There was no significant difference in overall survival between the two groups, although the prognosis for the NAC+OP+R group tended to be slightly better (P= 0.064). Taken together, these results suggest that the expression of MAD2 may predict the efficacy of NAC as a treatment for locally advanced uterine cervical cancer.

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Section: Balloon-occluded Arterial Infusion Chemotherapy (Boai)mentioning

confidence: 96%

Section: Balloon-occluded Arterial Infusion Chemotherapy (Boai)mentioning

confidence: 99%

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

Morishita

Sumi

Nakano

et al. 2011

Experimental and Therapeutic Medicine

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“…All patients underwent balloon-occluded arterial infusion chemotherapy for NAC. Cisplatin (Bristol-Myers Squibb, Tokyo, Japan) was infused intra-arterially through the catheter over 30 min (31).…”

Section: Methodsmentioning

confidence: 99%

UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer

et al. 2017

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“…Cis-diamminedichloro-platinum (CDDP; Bristol-Myers Squibb Company, New York, NY, USA) was intra-arterially infused through the two catheters over 30 min (34). In the current study, the two ovarian arteries were blocked following the initial BOAI procedure in order to increase the concentration of CDDP near the tumor.…”

Section: Balloon-occluded Arterial Infusion Chemotherapy (Boai) For Nacmentioning

confidence: 99%

Expression of epidermal growth factor-like domain 7 may be a predictive marker of the effect of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

et al. 2016

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Abstract. Neoadjuvant chemotherapy (NAC) followed by hysterectomy may be effective for the treatment of locally advanced uterine cervical cancer and improve patient prognosis. It is important to identify markers that are able to predict whether NAC may be successful. Epidermal growth factor-like domain 7 (EGFL7) regulates vascular sprouting in blood vessel formation. In numerous types of human cancer, EGFL7 is upregulated and inhibits endothelial cell adhesion molecules, decreasing vascular tightness and, thus, increasing vascular permeability. It is considered that the overexpression of EGFL7 is able to inhibit drug delivery, resistance to apoptosis and the epithelial-to-mesenchymal transition. In the current study, 63 patients with locally advanced uterine cervical cancer were reviewed and classified as stage IIIA-IIIB using the International Federation of Gynecology and Obstetrics criteria. These patients (aged <70 years) were treated at

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Effect of balloon occluded arterial infusion of anticancer drugs on the prognosis of cervical cancer treated with radiation therapy

Cited by 19 publications

References 18 publications

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer

Expression of epidermal growth factor-like domain 7 may be a predictive marker of the effect of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

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