2007
DOI: 10.1016/j.arcmed.2006.08.007
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Effect of Balneotherapy on the Antioxidant System—A Controlled Pilot Study

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Cited by 55 publications
(32 citation statements)
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“…They discussed that the decline of these enzyme-activities may be caused by two reasons: either as consequence of reduced oxidative stress during sulphur therapy leading to a lower expression of these enzymes or as an enhanced generation of superoxide radicals exhausting the superoxide scavenging enzyme. Bender et al demonstrated that therapeutic baths in mineral water reduced the activity of catalase, SOD, malondialdehyde and GSH peroxidise (Bender et al, 2007). Other authors have observed a significant decrease in NO and myeloperoxidase and a slight increase in GSH peroxidase in the sera of subjects with OA undergoing cycles of mud applications and balneotherapy (Bellometti et al, 2000).…”
Section: Anti-inflammatory and Chondroprotective Aspectsmentioning
confidence: 98%
“…They discussed that the decline of these enzyme-activities may be caused by two reasons: either as consequence of reduced oxidative stress during sulphur therapy leading to a lower expression of these enzymes or as an enhanced generation of superoxide radicals exhausting the superoxide scavenging enzyme. Bender et al demonstrated that therapeutic baths in mineral water reduced the activity of catalase, SOD, malondialdehyde and GSH peroxidise (Bender et al, 2007). Other authors have observed a significant decrease in NO and myeloperoxidase and a slight increase in GSH peroxidase in the sera of subjects with OA undergoing cycles of mud applications and balneotherapy (Bellometti et al, 2000).…”
Section: Anti-inflammatory and Chondroprotective Aspectsmentioning
confidence: 98%
“…Nustatytas poveikis hormonams (didėja prieširdžių natruretinio peptido, mažėja renino aktyvumas, mažėja aldosterono gamyba, mažėja anti-diuretinio hormono, didėja dopamino, keičiasi AKTH, kortizolio kiekiai, didėja ß-endorfino, augimo hormono, norepinefrino, prolaktino), lipidams (padidėja didelio tankio lipoproteinų), citokinams (TNF-α,IL-1α IL-1β,IL-6, IFN-γ , IL-2, IL-4, EGF, TGF-β1), prostaglandinams (PGE 2, LTB 4, PGF 2 α), ląstelių populiacijoms (Langerhanso, T-ir B-, CD4+, CD4-, CD8+, CD8 ląstelėms), C-reaktyviam baltymui, haptoglobulinui, medžiagai P, matrikso metaloproteazėms (MMP-1, MMP-2, mažėja MMP-3, didėja MMP-8, MMP-9), poveikis oksidacinei/antioksidacinei sistemai (sumažinama reaktyvaus deguonies (ROS) ir azoto (RNS) atmainų, katalazės, superoksido dismutazės, gliutationo peroksidazės aktyvumas, sumažėja glikolizuoto hemoglobino, β-2-mikroglobulino, azoto oksido, galimai stimuliuojama opioidų sekrecija, modifikuojami SERT (serotonimo transporteriai) receptoriai, gerėja afinitetas SERT. Nustatyta, kad spa terapija didina į insuliną panašaus augimo faktoriaus-1 (IGF1), kuris stimuliuoja kremzlės metabolizmą, ir transformuojančio augimo faktoriaus-β (TGF-β) kiekius [20][21][22][23][24][25][26][27]31]. Šių citokinų, chemokinų, uždegimo/ oksidacijos biomarkerių kaitos pasekoje pastebimas teigiamas poveikis reumatologinėms ligoms, depresijai, psoriazei, lėtiniam/alerginiam rinosinusitui, kraujospūdžiui, lėtinei obstrukcinei plaučių ligai ir kitiems susirgimams [3].…”
Section: Balneoterapijos Poveikio Mechanizmasunclassified
“…The inhibitory effect of balneotherapy on the production and/or release of IL-1, PGE2 and LTB4 could explain the mechanism of clinical benefits of spa therapy in this disorder. Mineral water may also influence the oxidantantioxidant system (Eckmekcioglu et al, 2002;Bender et al, 2007), which could be beneficial, since oxidative stress disorders have been described in FS (Bagis et al, 2005). Finally, other aspects of the mechanisms of mud packs and balneotherapy in FS need to be considered; for example, the climatic and environmental conditions of spas and the fact that people relax away from their daily routines (Sukenik et al, 1999;Fioravanti et al, 2011).…”
Section: Mechanisms Of Action Of Spa Therapy In Fsmentioning
confidence: 99%