In the present work, solidification structure and centre segregation in continuously cast bearing steel GCr15 blooms with 220mm×260 mm were obtained by different casting conditions (M-EMS, M + F-EMS, M + F-EMS + MSR), which were systematically optimized by numerical simulation and experiments. The relationship between centre segregation in continuously cast GCr15 bloom, heredity in hot-rolled steel and carbide inhomogeneity of hot-rolled steel with was investigated comprehensively. Results showed that compared with M-EMS, centre carbon segregation ratio in the bloom decreased from 1.1∼1.4 to 1.04∼1.22 by M + F-EMS, and could be reduced to 0.96∼1.08 by MSR in combination with M + F-EMS. Moreover, centre segregation in hot-rolled steel decreased with the decrease of centre segregation in bloom. Grade of network and banded carbide in hotrolled steel decreased accordingly, especially for centre carbon segregation ratio with 0.96∼1.08, grade of network and banded carbide could be significantly reduced to 1. It was important to control centre segregation in as-cast steel to improve the resulting carbide homogeneity of asrolled steel. According to the experimental results, higher casting speed in bloom with M + F-EMS and MSR integrated process was preferred to effectively reduce centre segregation ratio and further decreased the occurrence of network and banded carbide in as-rolled bearing steel GC15.