Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway

Chen, Shao‐Fang; Liang, Hang; Chen, Shaodong; Yan-ping, Huang; Shichuan, Wan; Yanxia, Huang

doi:10.1016/s0254-6272(18)30633-2

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Taken together, our results suggest that BST may be moderately helpful in FD via improvement of the overall symptoms, even though FD is a heterogeneous disorder and associated with complicated pathophysiological features, (Talley and Ford, 2015;Enck et al, 2017). These improvements may be due to the diverse functions of BST, such as anti-inflammatory function, enhancing gastric motility and protective function of mucosa (Nakazono et al, 2010;Shaofang et al, 2018;Bai et al, 2019;Jeon et al, 2019;Ji et al, 2021;Zenitani et al, 2021).…”

Section: Discussionmentioning

confidence: 61%

Efficacy of a Traditional Herbal Formula, Banha-Sasim-Tang in Functional Dyspepsia Classified as Excess Pattern

Kim

Kwon

et al. 2021

Front. Pharmacol.

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This study evaluated the efficacy and safety of Banha-sasim-tang (BST) in patients with functional dyspepsia (FD). BST (Banxia-xiexin-tang in traditional Chinese medicine and Hange-shashin-to in Kampo medicine) is traditionally prescribed for the treatment of dyspepsia with epigastric stiffness and gastric fullness in China, Japan, and Korea. Patients with FD were randomly administered an oral dose (10 g) of BST syrup or placebo, twice a day for 4 weeks. The primary outcome was the symptom checklist part of the Nepean dyspepsia index (NDI). The secondary outcomes were the quality of life (QoL) part of the NDI, functional dyspepsia-related QoL (FD-QoL), and visual analog scale (VAS). A total of 60 patients with FD were screened, and 50 were randomized into BST group (n = 25) and placebo group (n = 25). Two patients in the placebo group withdrew before the start of the treatment. Administration of BST syrup resulted in improvement in the symptom-related NDI score in the BST group compared with that in the control group; however, the difference was not significant. BST syrup significantly improved “fullness after eating” index of NDI at follow-up time point (2.88 ± 2.65 vs 4.78 ± 2.69, p = 0.0081). In the total score of the QoL section of the NDI and FD-QoL scales, there was no significant improvement in the BST group compared to that in the placebo group. With regard to improvement in overall FD symptoms, the VAS scale showed improvement in both groups, but the difference was not significant. Interestingly, follow-up investigation showed a significantly beneficial effect of BST on FD symptoms, when compared to placebo. Significant improvement observed in VAS score (39.60 ± 22.29 vs 52.17 ± 20.55, p = 0.048). This indicated that the effect of BST lasted even after the completion of the medication regimen. Overall, our data suggest that while BST showed no significant improvement in the symptom-related NDI score and the QoL related scores in NDI and FD-QoL after 4 weeks of treatment, it effectively improved the VAS score and fullness after eating-related symptoms in the follow-up visit.Clinical Trial Registration:https://cris.nih.go.kr; Identifier KCT 0002013

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Section: Discussionmentioning

confidence: 61%

Efficacy of a Traditional Herbal Formula, Banha-Sasim-Tang in Functional Dyspepsia Classified as Excess Pattern

Kim

Kwon

et al. 2021

Front. Pharmacol.

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“…[ 14 ] In Hp-treated GES-1 cells, Chen et al found that treatment with the BXD-containing serum could suppress the expression of TGF-β1 and Smad3, and increase the expression of Smad7 in a dose-dependent manner. [ 70 ] Qu et al tested the antibacterial effect of BXD on the 8 strains of Hp resistant strains separated from patients. The results demonstrated that BXD had strong bacteriostatic effect on the bacteria resistance of Hp strains in vitro, suggesting that it may be employed as a therapeutic choice for resistant Hp-related gastritis.…”

Section: Anti-bacterialmentioning

confidence: 99%

Banxia Xiexin decoction: A review on phytochemical, pharmacological, clinical and pharmacokinetic investigations

Zhou,

An,

You

et al. 2023

Medicine

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Banxia Xiexin decoction (BXD), a famous traditional Chinese prescription constituted by Pinelliae Rhizoma, Zingiberis Rhizoma, Scutellariae Radix, Coptidis Rhizoma, Ginseng Radix et Rhizoma, Jujubae Fructus and Glycyrrhizae Radix et Rhizoma Praeparata Cum Mell, has notable characteristics of acrid-opening, bitter down-bearing and sweet-tonification, interfering with tumors, gastrointestinal diseases, central nervous system diseases and much more. Based on the wide clinical applications, current investigations of BXD focused on several aspects: chemical analysis to explore the underlying substrates responsible for the therapeutic effects; basic studies on pharmacological actions of the whole prescription or of those representative ingredients to demonstrate the intriguing molecular targets for specific pathological processes; pharmacokinetic feature studies of single or all components of BXD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological, clinical and pharmacokinetic profiles of BXD and its herbal or pharmacologically active chemicals, as well as discussions of our understanding which further reveals the significance of BXD clinically.

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“…Because the etiology and pathogenesis of cold-hot complicated syndrome are complicated, it is difficult to treat this syndrome by using cold TCMs or hot TCMs alone. For this complicated syndrome, formulas composed of cold and hot TCMs can be used (Chen et al, 2018). Shanghan Lun, a canonical book of TCM written by Zhang Zhongjing, contains a large number of examples of combinational use of cold and hot medicines, such as Banxia Xiexin Decoction, Xiao Chaihu Decoction (Shao and Li, 2019), and Wumei Pill (Yan et al, 2012).…”

Section: The Classification and Treatment Of Cold And Hot Syndromesmentioning

confidence: 99%

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

2021

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The theory of cold and hot properties is the basic theory of traditional Chinese medicines (TCMs) and has been successfully applied to combat human diseases for thousands of years. Although the theory of cold and hot is very important to guide the clinical application of TCMs, this ancient theory remains an enigma for a long time. In recent years, more and more researchers have tried to uncover this ancient theory with the help of modern techniques, and the cold and hot properties of a myriad of TCMs have been studied. However, there is no review of cold and hot properties. In this review, we first briefly introduced the basic theories about cold and hot properties, including how to distinguish between the cold and hot properties of TCMs and the classification and treatment of cold and hot syndromes. Then, focusing on the application of cold and hot properties, we take several important TCMs with cold or hot property as examples to summarize their traditional usage, phytochemistry, and pharmacology. In addition, the mechanisms of thermogenesis and antipyretic effect of these important TCMs, which are related to the cold and hot properties, were summarized. At the end of this review, the perspectives on research strategies and research directions of hot and cold properties were also offered.

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Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway

Cited by 6 publications

References 25 publications

Efficacy of a Traditional Herbal Formula, Banha-Sasim-Tang in Functional Dyspepsia Classified as Excess Pattern

Efficacy of a Traditional Herbal Formula, Banha-Sasim-Tang in Functional Dyspepsia Classified as Excess Pattern

Banxia Xiexin decoction: A review on phytochemical, pharmacological, clinical and pharmacokinetic investigations

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

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