Effect of bariatric surgery on circulating chemerin levels

Ress, Claudia; Tschoner, Alexander; Engl, Julia; Alexander, Klaus; Tilg, Herbert; Ebenbichler, Christoph; Patsch, J; Kaser, Susanne

doi:10.1111/j.1365-2362.2010.02255.x

Cited by 86 publications

(64 citation statements)

References 12 publications

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“…Circulating chemerin levels are known to be associated with obesity in humans (11,15,26,27,28,29). In this study, hepatic chemerin mRNA expression was found to be significantly associated with BMI (R 2 Z0.296; PZ0.039), waist circumference (R 2 Z0.397; PZ0.005), and body fat percentage (R 2 Z0.378; PZ0.008).…”

Section: Resultsmentioning

confidence: 52%

“…Several human studies have investigated the association between chemerin levels in the serum and different metabolic disorders (24): obese subjects (BMI O30 kg/m 2 ) have higher plasma chemerin levels than normal-weight subjects (BMI !25 kg/m 2 ) (11,27), and pronounced weight loss after gastric bypass surgery has been reported to decrease serum chemerin levels (15,28,29). An association of circulating chemerin levels with the markers of NAFLD has also been highlighted, but the results have been inconsistent in terms of some of the investigated histological features (28,30,31).…”

Section: Introductionmentioning

confidence: 99%

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Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

Döcke

Lock

Birkenfeld

et al. 2013

European Journal of Endocrinology

118

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Objective: Adipose tissue-derived factors link non-alcoholic fatty liver disease (NAFLD) with obesity, which has also been reported for circulating chemerin. On the other hand, hepatic chemerin and chemokine-like receptor 1 (CMKLR1) mRNA expression has not yet been studied in an extensively characterized patient collective. Design: This study was cross-sectional and experimental in design. Methods: Liver tissue samples were harvested from 47 subjects and histologically examined according to the NAFLD activity score (NAS). The concentrations of chemerin and CMKLR1 were measured using semi-quantitative real-time PCR, and the concentration of serum chemerin was measured using ELISA. To evaluate potential effects of chemerin and CMKLR1, cultured primary human hepatocytes (PHHs) were exposed to selected metabolites known to play a role in NAFLD (insulin, glucagon, palmitoic acid, and interleukin-6 (IL6)). Results: Chemerin and CMKLR1 mRNA levels were elevated in the human liver. Their expression was correlated with the NAS (R 2 Z0.543; P!0.001 and R 2 Z0.355; PZ0.014 respectively) and was significantly elevated in patients with definite non-alcoholic steatohepatitis (NASH) (P!0.05 respectively). Linear regression analysis confirmed an independent association of liver fibrosis, steatosis, inflammation, and hepatocyte ballooning with hepatic chemerin mRNA expression (P!0.05 respectively). The expression of hepatic chemerin and CMKLR1 was correlated with the measures of obesity (P!0.05). The incubation of PHHs with IL6 significantly increased the expression of CMKLR1 mRNA (PZ0.027), while that of chemerin remained unaffected (PO0.05). None of the other metabolites showed an influence (PO0.05). Conclusion: This is the first study to show that chemerin mRNA expression is significantly elevated in the liver of NASH patients and that CMKLR1 expression is upregulated in liver inflammation, whereby IL6 could play a causal role.

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Section: Resultsmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

Döcke

Lock

Birkenfeld

et al. 2013

European Journal of Endocrinology

118

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“…We found that the serum chemerin levels were significantly decreased in the male patients with T2DM. The reason for the discrepancy in the relationship between serum chemerin levels and T2DM is unknown; however, studies including the current investigation, have consistently reported that the serum chemerin levels are positively correlated with BMI [12,[16][17][18][19], suggesting that the amount of adipose tissue is a main regulator of the serum chemerin levels.…”

Section: Resultsmentioning

confidence: 58%

“…In particular, serum chemerin levels are closely associated with body mass index (BMI) [12,[16][17][18][19]. Indeed, serum chemerin levels significantly decreased after bariatric surgery according to BMI reduction [18,20].…”

Section: Preparation Of Anti-chemerin Monoclonal Antibodymentioning

confidence: 99%

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Takahashi

Inomata²,

Okimura

et al. 2013

Endocr J

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TYPE 2 DIABETES MELLITUS (T2DM)results from the development of insulin resistance and a concomitant impairment of insulin secretion. Under these conditions, adipokines, which are secreted by the adipose tissue, play a pivotal role [1,2]. Adipokines such as leptin, adiponectin, and resistin regulate energy and glucose homeostasis. Adipocytes also secrete inflamDecreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism Abstract. Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the role of chemerin in the pathogenesis of type 2 diabetes mellitus (T2DM) has not fully been elucidated. We compared the serum chemerin levels and metabolic parameters between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 patients with T2DM in a Japanese population and further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure the serum chemerin levels. The chemerin levels were significantly higher in male than in female control subjects (p < 0.005), with significant decreases in patients with T2DM compared with those with MS and control subjects (164.9 ± 6.3 ng/mL vs. 209.8 ± 7.7 and 218.7 ± 7.3 ng/mL; p < 0.0001 vs. p < 0.0001, respectively) but no significant differences in female subjects. The multiple regression analysis revealed that the chemerin levels negatively correlated with the fasting glucose and HbA1c levels in total and male subjects. In the patients with T2DM, the chemerin levels negatively correlated with fasting glucose and high-density lipoprotein cholesterol but positively correlated with body mass index (BMI), and total cholesterol and triglyceride levels. The negative correlation between the chemerin and fasting glucose levels remained significant after adjustment for age, sex, and BMI in the total and male subjects and those with T2DM. These results suggest the role of chemerin in sex dimorphism and a potential link between chemerin levels and T2DM pathogenesis in a Japanese population.

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“…Compared with lean animals, chemerin gene expression is elevated in the adipose tissue of obese animals, and expression levels are markedly elevated during the differentiation of 3T3-L1 cells into mature adipocytes (Bozaoglu et al, 2007). Moreover, chemerin has been suggested to play a role in mediating the long-term beneficial effects of bariatric surgery (Ress et al, 2010). Because chemerin seems to play several roles in both inflammation and metabolism, it has been proposed as a link between chronic inflammation, obesity, and obesity-related comorbidities Yang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Differential Patterns of Serum Concentration and Adipose Tissue Expression of Chemerin in Obesity: Adipose Depot Specificity and Gender Dimorphism

Alfadda

Sallam

Chishti

et al. 2012

Molecules and Cells

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Effect of bariatric surgery on circulating chemerin levels

Cited by 86 publications

References 12 publications

Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism

Differential Patterns of Serum Concentration and Adipose Tissue Expression of Chemerin in Obesity: Adipose Depot Specificity and Gender Dimorphism

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