Effect of bariatric surgery on peripheral flow-mediated dilation and coronary microvascular function

Insulin Resistance and not BMI is the Major Determinant of Early Vascular Impairment in Patients with Morbid Obesity

“…An increased IMT, which indicates the pattern of initial structural lesions in the carotid arteries, has been reported in asymptomatic young overweight/obese subjects with metabolic syndrome 3) . Furthermore, an improved endothelial function and reduced IMT have been documented after bariatric surgery 18) , although the improvement in FMD is not always correlated with a reduction in weight and BMI 19) . Obesity-related vascular impairment occurs starting early in life; in autoptic reports of adolescents and young adults, obesity is associated with the extent When we divided the same group according to the median BMI values, we observed that the subjects with a higher BMI, although they had higher visceral fat area and HOMA-IR values, exhibited no significant differences in lipid parameters, FMD or IMT.…”

Differential effects of heart rate reduction by atenolol or ivabradine on peripheral endothelial function in type 2 diabetic patients

“…Peripheral vasodilator function was assessed by the same expert operator using methods previously described in detail 17 18. Systemic endothelium-dependent vasodilation was assessed by measuring flow-mediated dilation (FMD).…”

Obesity: a new risk factor for cardiac syndrome X?

“…In a recent study of young morbidly obese patients without cardiovascular disease, we have indeed shown that weight loss by bariatric surgery significantly improved both peripheral ED and CMVD, but systemic ED improvement only correlated with that of endotheliumdependent CMVD, but not with that of endotheliumindependent CMVD [10].…”