Effect of bariatric surgery on normal and abnormal renal function

Schuster, Dara; Teodorescu, M; Mikami, Dean J.; Foreman, Kym; Rogers, Philip; Needleman, Bradley J.

doi:10.1016/j.soard.2010.11.015

Cited by 33 publications

(25 citation statements)

References 28 publications

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“…A number of studies have shown that surgical weight loss is associated with reduction in serum creatinine, albuminuria and proteinuria, and also with an improvement of GFR [33,34,35,36,37]. In a study, 70 extremely obese adults were prospectively studied before and 12 months after bariatric surgery and were compared with 24 normal-weight adults [38].…”

Section: Weight Loss and Kidney Diseasementioning

confidence: 99%

Management of Obesity-Induced Kidney Disease: A Critical Review of the Literature

Kiortsis¹,

Christou²

2012

Obes Facts

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It is well established that obesity is a risk factor for the development of chronic kidney disease (CKD) and may promote the progression to end stage renal disease (ESRD). Therefore, it is strongly suggested that reduction of body weight can be an important intervention in order to reduce the prevalence of renal impairment. The current article describes extensively the already published trials which have studied the association between weight loss and kidney disease. The weight management programs include surgical and non-surgical interventions (low-calorie diet, aerobic exercise, drug-induced weight loss, combination treatment). The focus has been placed on the following renal function markers: albuminuria, proteinuria, glomerular filtration rate (GFR), and creatinine clearance. This review also aims to clarify challenges that clinicians have to deal with in everyday practice regarding the management of obesity-induced kidney disease (degree of weight loss, duration of the weight loss program, early initiation of the intervention).

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Section: Weight Loss and Kidney Diseasementioning

confidence: 99%

Management of Obesity-Induced Kidney Disease: A Critical Review of the Literature

Kiortsis¹,

Christou²

2012

Obes Facts

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“…As highlighted by Johnson et al (4), noted in Table 1, and referenced in a review article of bariatric surgery and microvascular complications by Jackson et al (3), a number of recently reported studies (many of which were small and uncontrolled) demonstrated favorable outcomes in renal function markers following bariatric/metabolic surgery in patients with or without the presence of impaired renal function before their bariatric surgery (68,70,75–78,83–86). Finally, patients who are waiting for or who have had renal transplantation experienced improved renal function following bariatric surgery (80,87,90–92), and a few bariatric surgery studies demonstrated varying degrees of improvement in neuropathy and ophthalmic outcomes (4,71,79,81,82,88,93).…”

Section: Microvascular and Macrovascular Complications: Reviewmentioning

confidence: 99%

Clinical Outcomes of Metabolic Surgery: Microvascular and Macrovascular Complications

et al. 2016

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Understanding of the long-term clinical outcomes associated with bariatric surgery has recently been advanced. Research related to the sequelae of diabetes—in particular, long-term microvascular and macrovascular complications—in patients who undergo weight-loss surgery is imperative to this pursuit. While numerous randomized control trials have assessed glucose control with bariatric surgery compared with intensive medical therapy, bariatric surgery outcome data relating to microvascular and macrovascular complications have been limited to observational studies and nonrandomized clinical trials. As a result, whether bariatric surgery is associated with a long-term reduction in microvascular and macrovascular complications when compared with current intensive glycemic control therapy cannot be determined because the evidence is insufficient. However, the consistent salutary effects of bariatric surgery on diabetes remission and glycemic improvement support the opportunity (and need) to conduct high-quality studies of bariatric surgery versus intensive glucose control. This review provides relevant background information related to the treatment of diabetes, hyperglycemia, and long-term complications; reports clinical findings (to date) with bariatric surgery; and identifies ongoing research focusing on long-term vascular outcomes associated with bariatric surgery.

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“…An increased glomerular filtration rate (GFR) was observed in overweight compared with lean subjects, being significantly positively related to BMI [62][63] and insulin resistance. [64] However, pathologic changes within the nephron can be seen before overt proteinuria and renal disease. A recent study conducted in our institution revealed that bariatric surgery induced weight loss is associated with an improvement in the overall long term renal function in the morbidly obese adult.…”

Section: Renal Systemmentioning

confidence: 99%