Effect of basic fibroblast growth factor on the proliferation, migration and phenotypic modulation of airway smooth muscle cells

Zou, Hui; Nie, Xin; Zhang, Yi; Hu, Mu; Zhang, Yu Alex

doi:10.1097/00029330-200803010-00011

Cited by 15 publications

(11 citation statements)

References 29 publications

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“…The most widely studied FGF ligand in asthma is FGF2. FGF2 induces the expression of platelet‐derived growth factor receptor alpha ( PDGFRa ) in human‐derived ASMCs (Bonner et al, ) and induces proliferation and migration in vitro (Zou et al, ). Furthermore, FGF2 is thought to contribute to subepithelial collagen deposition, and it has been suggested that through the release of heparin and endoglycosidase, mast cells induce the release of FGF2 from heparan sulphate proteoglycans in asthmatic lungs (Shute et al, ) (Fig.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

Agha

Seeger

Bellusci

2016

Developmental Dynamics

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Fibroblast growth factors (FGFs) constitute a large family of polypeptides that are involved in many biological processes, ranging from prenatal cell-fate specification and organogenesis to hormonal and metabolic regulation in postnatal life. During embryonic development, these growth factors are important mediators of the crosstalk among ectoderm-, mesoderm-, and endoderm-derived cells, and they instruct the spatial and temporal growth of organs and tissues such as the brain, bone, lung, gut, and others. The involvement of FGFs in postnatal lung homeostasis is a growing field, and there is emerging literature about their roles in lung pathophysiology. In this review, the involvement of FGF signaling in a wide array of lung diseases will be summarized. Developmental Dynamics 246:235-244,

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Section: Introductionmentioning

confidence: 99%

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

Agha

Seeger

Bellusci

2016

Developmental Dynamics

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“…It is a single-strand protein with a molecular weight of ~17 kDa and a pI of 9.6. It can stimulate the proliferation of NIH/3T3 cells and inhibit the differentiation of stem cells, and may play an important role in curing asthma because of its capacity for proliferation, migration and changing the contractile phenotypes of human airway smooth muscle cells in vitro [4]. Subsequently, bFGF has been found to stimulate the growth of mouse mammary epithelial cells [5].…”

Section: Introductionmentioning

confidence: 99%

Expression of a Functional Recombinant Human Basic Fibroblast Growth Factor from Transgenic Rice Seeds

Jiang

et al. 2013

IJMS

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Basic fibroblast growth factor (FGF-2) is an important member of the FGF gene family. It is widely used in clinical applications for scald and wound healing in order to stimulate cell proliferation. Further it is applied for inhibiting stem cell differentiation in cultures. Due to a shortage of plasma and low expression levels of recombinant rbFGF in conventional gene expression systems, we explored the production of recombinant rbFGF in rice grains (Oryza sativa bFGF, OsrbFGF). An expression level of up to 185.66 mg/kg in brown rice was obtained. A simple purification protocol was established with final recovery of 4.49% and resulting in a yield of OsrbFGF reaching up to 8.33 mg/kg OsrbFGF. The functional assay of OsrbFGF indicated that the stimulating cell proliferation activity on NIH/3T3 was the same as with commercialized rbFGF. Wound healing in vivo of OsrbFGF is equivalent to commercialized rbFGF. Our results indicate that rice endosperm is capable of expressing small molecular mass proteins, such as bFGF. This again demonstrates that rice endosperm is a promising system to express various biopharmaceutical proteins.

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“…FGF2 is a potent mitogen for various cells, including fibroblasts, alveolar epithelial cells and airway smooth muscle cells; in addition, FGF2 induces collagen synthesis in lung fibroblasts and myofibroblasts [36][37][38][39]. FGF2 levels, as well as expression of FGFR1 on epithelial, endothelial and smooth muscle cells or myofibroblastlike cells, and expression of FGFR2 on interstitial cells, are increased in patients with IPF [39,40].…”

Section: Idiopathic Pulmonary Fibrosis Disease Pathogenesis and Mechmentioning

confidence: 99%

Discovery and Development of Nintedanib: A Novel Antiangiogenic and Antifibrotic Agent

Roth¹,

Binder²,

Colbatzky³

et al. 2016

Successful Drug Discovery

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Effect of basic fibroblast growth factor on the proliferation, migration and phenotypic modulation of airway smooth muscle cells

Cited by 15 publications

References 29 publications

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

Expression of a Functional Recombinant Human Basic Fibroblast Growth Factor from Transgenic Rice Seeds

Discovery and Development of Nintedanib: A Novel Antiangiogenic and Antifibrotic Agent

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