Effect of batch-to-batch variation of spray dried lactose on the performance of feeders

Janssen, Pauline H.M.; Kulkarni, Sri Sharath; Torrecillas, Carlota Mendez; Tegel, Florian; Weinekötter, Ralf; Meir, Bernhard; Dickhoff, Bastiaan H.J.

doi:10.1016/j.powtec.2022.117776

Cited by 4 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 288 ] The variability in the starting materials can lead to irregularities in the above‐mentioned parameters of the synthesized polymers. [ 289 ] In the industrial setting, managing the reactivity of cationic monomers can be another hurdle that requires complete control of the reaction conditions such as temperature, pH, monomer concentration. [ 290 ] Laboratory‐to‐industrial‐scale polymer synthesis generally introduces batch‐to‐batch variability due to changes in equipment and the environmental conditions.…”

Section: Clinical Outlook For Polymeric Gene Therapeuticsmentioning

confidence: 99%

Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Jogdeo,

Siddhanta,

Das

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

The recent success of gene therapy during the COVID‐19 pandemic has underscored the importance of effective and safe delivery systems. Complementing lipid‐based delivery systems, polymers present a promising alternative for gene delivery. Significant advances have been made in the recent past, with multiple clinical trials progressing beyond phase I and several companies actively working on polymeric delivery systems which provides assurance that polymeric carriers can soon achieve clinical translation. The massive advantage of structural tunability and vast chemical space of polymers is being actively leveraged to mitigate shortcomings of traditional polycationic polymers and improve the translatability of delivery systems. Tailored polymeric approaches for diverse nucleic acids and for specific subcellular targets are now being designed to improve therapeutic efficacy. This review describes the recent advances in polymer design for improved gene delivery by polyplexes and covalent polymer‐nucleic acid conjugates. The review also offers a brief note on novel computational techniques for improved polymer design. We conclude with an overview of the current state of polymeric gene therapies in the clinic as well as future directions on their translation to the clinic.This article is protected by copyright. All rights reserved

show abstract

Section: Clinical Outlook For Polymeric Gene Therapeuticsmentioning

confidence: 99%