Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis

Hormoznejad, Razie; Javid, Ahmad Zare; Mansoori, Anahita

doi:10.1007/s11332-019-00542-4

Cited by 31 publications

(41 citation statements)

References 59 publications

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“…To the best of our knowledge, no meta-analysis has been previously proposed with this restrictive set of criteria. Most of previous meta-analyses [23][24][25] reviewing the effect of BCAAs on muscle damage did not exclude the factors of sex, physical fitness statuses, types of exercise, and supplementation interventions.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the effects of BCAAs on the EIMD mitigation and muscle soreness have been widely investigated under different exercise conditions and populations, even though heterogeneity exists among outcomes and methodological quality [22]. A summary of evidence is available from previous meta-analyses [23][24][25]. Evidence demonstrates the potential positive effect of BCAAs supplementation on muscle damage, muscle soreness and function [23], fatigue substances, energy metabolites and muscle soreness substances [24], and muscle damage [25].…”

Section: Introductionmentioning

confidence: 99%

“…A summary of evidence is available from previous meta-analyses [23][24][25]. Evidence demonstrates the potential positive effect of BCAAs supplementation on muscle damage, muscle soreness and function [23], fatigue substances, energy metabolites and muscle soreness substances [24], and muscle damage [25]. The previous meta-analyses have been conducted with broad eligibility criteria in terms of gender (both male and female participants), training status (trained and untrained populations), type of exercise (endurance, resistance, or specific sports), and supplementation interventions (BCAAs combined with other amino acids and vitamins).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Previous studies have reported the positive effects of branched-chain amino acids (BCAAs) supplementation on lowering plasma markers of muscle damage and subjective soreness after resistance exercise. However, a variety of factors can potentially moderate its efficacy. This meta-analysis aimed to summarize the evidence regarding the effect of BCAAs supplementation on plasma muscle damage markers and soreness after resistance exercise in only trained males, by considering the plasma lactate dehydrogenase (LDH) and creatine kinase (CK). Randomized controlled trials were identified through a computerized literature search for the period 2010–2020. The pooled data were analyzed with the random-effects model and heterogeneity using I2. Cochrane Collaboration tools was used for the assessment of risk of bias. Nine studies met the inclusion criteria. A positive effect was found for CK at <24, 24, and 48 h after exercise and for muscle soreness at <24 h only. However, the positive effect was not evident for plasma LDH at any follow-up time. Different outcomes for post-exercise responses may suggest that BCAAs supplementation can attenuate muscle damage and ameliorate muscle soreness after resistance exercise in trained males.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

et al. 2021

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“…On the other hand, it appears that supplementation with branched-chain amino acids (BCAA) after high-intensity exercise may favor a hormonal environment that contributes to attenuate the loss of strength, reduce muscle damage, and generate an anabolic environment [ 127 ]. Indeed, several systematic reviews and meta-analysis have concluded that BCAA supplementation (>200 mg·kg −1 ·day −1 ) may optimize recovery and mitigate muscle soreness following muscle-damaging exercise [ 128 , 129 , 130 , 131 ]. Notwithstanding, in resistance-trained males, the attenuation of muscular performance decrements and the observed decrease in plasma CK levels after BCAA supplementation is likely negligible when consumed with a diet consisting of ~1.2 g·kg −1 ·day −1 of protein [ 132 ].…”

Section: Resultsmentioning

confidence: 99%

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

Bonilla

Pérez-Idárraga

Odriozola-Martínez

et al. 2020

IJERPH

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Post-exercise recovery is a broad term that refers to the restoration of training capacity. After training or competition, there is fatigue accumulation and a reduction in sports performance. In the hours and days following training, the body recovers and performance is expected to return to normal or improve. ScienceDirect, PubMed/MEDLINE, and Google Scholar databases were reviewed to identify studies and position declarations examining the relationship between nutrition and sports recovery. As an evidence-based framework, a 4R’s approach to optimizing post-exercise recovery was identified: (i) Rehydration—a fundamental process that will depend on the athlete, environment and sports event; (ii) Refuel—the consumption of carbohydrates is not only important to replenish the glycogen reserves but also to contribute to the energy requirements for the immune system and tissue reparation. Several bioengineered carbohydrates were discussed but further research is needed; (iii) Repair—post-exercise ingestion of high-quality protein and creatine monohydrate benefit the tissue growth and repair; and (iv) Rest—pre-sleep nutrition has a restorative effect that facilitates the recovery of the musculoskeletal, endocrine, immune, and nervous systems. Nutritional consultancy based on the 4R’s is important for the wise stewardship of the hydration, feeding, and supplementation strategies to achieve a timely recovery.

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“…Another potential benefits of exogenous ketones in recovery is to alleviate the sensation of fatigue. During exercise, levels of free tryptophan entering the brain are increased, causing an increase in 5-hydroxytryptamine (5-HT), a contributor to the sensation of fatigue ( Watson et al, 2004 ; Hormoznejad et al, 2019 ). Ketone monoester was previously shown to decrease blood FFA ( Cox et al, 2016 ).…”

Section: Exogenous Ketones In Recoverymentioning

confidence: 99%

Ketones for Post-exercise Recovery: Potential Applications and Mechanisms

Mansor¹,

Woo²

2021

Front. Physiol.

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Ketogenic diet has been introduced in therapeutic areas for more than a century, but the role of ketones in exercise performance has only been explored in the past decade. One of the main reasons that allows the investigation of the role of ketones in exercise performance is the emergence of exogenous ketones, allowing athletes to achieve the state of ketosis acutely, and independent of their metabolic states. While there are mixed results showing either exogenous ketones improve exercise performance or no effect, the mechanisms of action are still being heavily researched. Moreover, these early data from exercise physiology studies suggested that exogenous ketones may play a more prominent role in post-exercise recovery, leading to a more pronounced cumulative impact over subsequent exercise performance. This review will look at existing evidence on the role of ketones in recovery and attempt to identify the current best practices and potential mechanisms that drive improved recovery.

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Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis

Cited by 31 publications

References 59 publications

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

Ketones for Post-exercise Recovery: Potential Applications and Mechanisms

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