Effect of beer on the plasma concentrations of uridine and purine bases

Yamamoto, Tetsuya; Moriwaki, Yuji; Takahashi, Sumio; Tsutsumi, Zenta; Ka, Tsuneyoshi; Fukuchi, Minoru; Hada, Toshikazu

doi:10.1053/meta.2002.34041

Cited by 46 publications

(48 citation statements)

References 14 publications

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“…Lifestyle and dietary habits also have a large influence on SUA. Several studies have reported that alcohol [47] and fructose [48] consumption can also be associated with high SUA. On the other hand, experimental data have confirmed that human atherosclerotic plaque contains large amounts of UA, and elevated SUA may promote thrombus formation via increasing platelet adhesiveness [5,6].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease

Yuan²,

Ding³

et al. 2016

Cardiology

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Objectives: Several studies have investigated the association between serum uric acid (SUA) and the risks of coronary artery disease (CAD) but have yielded inconsistent results. The aim of this study was to assess whether there is an independent association of SUA with all-cause and cardiovascular disease (CVD) mortality in Chinese patients with CAD. Methods: A prospective cohort study of 1,799 patients was conducted. Cox regression models were used to estimate the association of SUA with the risk of death. Results: During a median follow-up of 3.9 years, 177 deaths were recorded and 126 of these were due to CVD. Patients in the highest SUA quartile had a 2.43-fold risk of all-cause mortality and a 2.44-fold risk of CVD mortality compared with those in the lowest quartile. In the subpopulation analysis, the association between SUA and mortality remained similar when participants were stratified by age, gender, body mass index and type of CAD. In contrast, we found a significant interaction with estimated glomerular filtration rate (eGFR). There was a stronger association between SUA and the risk of all-cause and CVD mortality among patients with an eGFR ≥60 ml/min/1.73 m², but no significant association was found in the population with an eGFR <60 ml/min/1.73 m². Conclusions: Elevated SUA levels were positively associated with an increased risk of all-cause and CVD mortality among CAD patients.

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Section: Discussionmentioning

confidence: 99%

Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease

Yuan²,

Ding³

et al. 2016

Cardiology

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“…2 Furthermore, alcohol consumption increases the level of serum UA. [3][4][5][6][7] In addition to the increase of ATP production by alcohol, the frequency of prevalence of gout is rising through the synergistic effect of purines present in beer. 8,9 Most diets that affect serum UA levels affect either the synthesis or excretory pathways of UA.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Intra- and Extracellular Levels of Purine Bases, Nucleosides, and Nucleotides in HepG2 Cells by High-performance Liquid Chromatography

2015

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To evaluate cellular uptake and purine transport, we developed a high-performance liquid chromatography method for intra-and extracellular purine quantification. Our aim was to develop an effective method for simultaneously quantifying the substrate and metabolites with high sensitivity. C18 columns from different manufacturers were tested for simultaneous quantification of 22 different purine bases, nucleosides, and nucleotides. We used a YMC-Triart C18 column. The analysis conditions, including extraction solutions for the cells and cell culture medium, were optimized to achieve good quantification. Linearity, accuracy, determination limits, and recovery were assessed and showed good performance. The developed HPLC method was successfully applied to the qualitative analysis of 22 different intra-and extracellular purines, demonstrating that it is useful for studying the overall pattern of purine metabolism. This method could also be useful for evaluating metabolic dynamics of purines under a variety of stimulatory conditions of culture cells.

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“…[8][9][10][11][12] According to the Health Professionals Follow-up Study, the increase in serum uric acid level is associated with both the amount of alcohol consumption and the type of alcoholic beverage. 3,[13][14][15][16] Beer confers a higher risk than spirits, whereas moderate wine drinking does not increase risk. Low-malt and low-purine beer has little effect on serum uric acid concentration, in contrast to many other beers.…”

Section: Introductionmentioning

confidence: 99%

“…Low-malt and low-purine beer has little effect on serum uric acid concentration, in contrast to many other beers. 13,17 In addition, non-alcoholic or low-alcohol beer also increases the level of uric acid in serum, despite the beverages having little or no alcohol. 13,18 Thus, the purine concentration in beer, rather than its alcohol content, is related to the higher prevalence of gout.…”

Section: Introductionmentioning

confidence: 99%

“…13,17 In addition, non-alcoholic or low-alcohol beer also increases the level of uric acid in serum, despite the beverages having little or no alcohol. 13,18 Thus, the purine concentration in beer, rather than its alcohol content, is related to the higher prevalence of gout. Therefore, the analysis of the exact purine content of beer and beer-like alcoholic beverages is useful for helping consumers maintain a low serum uric acid level.…”

Section: Introductionmentioning

confidence: 99%

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A Simple HPLC Method for Determining the Purine Content of Beer and Beer-like Alcoholic Beverages

et al. 2013

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Effect of beer on the plasma concentrations of uridine and purine bases

Cited by 46 publications

References 14 publications

Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease

Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease

Analysis of Intra- and Extracellular Levels of Purine Bases, Nucleosides, and Nucleotides in HepG2 Cells by High-performance Liquid Chromatography

A Simple HPLC Method for Determining the Purine Content of Beer and Beer-like Alcoholic Beverages

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