Effect of Behcet's disease‐associated oral ulcers on oral health related quality of life

Ali, Shereen; Nagieb, Clair Sobhy; Fayed, Hala Lotfy

doi:10.1111/scd.12782

Cited by 3 publications

(15 citation statements)

References 31 publications

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“…The connection between oral health and these diseases is largely attributed to inflammation, although there are two other pathways that may explain the association [ 19 , 20 , 21 ]. Firstly, some systemic diseases have direct links to negative impacts on oral health and oral health-related quality of life (OHRQoL), such as Crohn’s disease [ 22 , 23 ], Beçhet’s disease [ 24 , 25 , 26 ], scleroderma [ 27 , 28 ], oral cancer [ 29 , 30 , 31 , 32 ], head and neck cancer [ 33 ], and Sjögren’s syndrome [ 34 , 35 , 36 , 37 ]. Secondly, some chronic diseases may indirectly affect oral health, as they can lead to reduced motivation regarding oral hygiene and care.…”

Section: Diseases and Oral Healthmentioning

confidence: 99%

An Overview of Systemic Health Factors Related to Rapid Oral Health Deterioration among Older People

Putten

Baat²

2023

JCM

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The oral health of older individuals can be negatively impacted by various systemic health factors, leading to rapid oral health deterioration. This paper aims to present an overview of the published evidence on systemic health factors that contribute to rapid oral health deterioration in older individuals, and to explore the implications of these factors for both general healthcare and oral healthcare provision. Older people are at risk of experiencing adverse reactions to medications due to multimorbidity, polypharmacy, and changes in pharmacokinetics and pharmacodynamics. Hyposalivation, a significant side effect of some medications, can be induced by both the type and number of medications used. Frailty, disability, sarcopenia, care dependency, and limited access to professional oral healthcare can also compromise the oral health of older people. To prevent rapid oral health deterioration, a comprehensive approach is required that involves effective communication between oral healthcare providers, other healthcare providers, and informal caregivers. Oral healthcare providers have a responsibility to advocate for the importance of maintaining adequate oral health and to raise awareness of the serious consequences of weakened oral health. By doing so, we can prevent weakened oral health from becoming a geriatric syndrome.

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Section: Diseases and Oral Healthmentioning

confidence: 99%

An Overview of Systemic Health Factors Related to Rapid Oral Health Deterioration among Older People

Putten

Baat²

2023

JCM

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“…The connection between oral health and these diseases is largely attributed to inflammation, although there are two other pathways that may explain the association [19][20][21]. Firstly, some systemic diseases have direct links to negative impacts on oral health and oral health-related quality of life (OHRQoL), such as Crohn's disease, Beçhet's disease, oral cancer, Sjögren's syndrome, and scleroderma [22][23][24][25][26][27][28][29][30][31][32]. Secondly, some chronic diseases may indirectly affect oral health because they can lead to reduced motivation regarding oral hygiene and care.…”

Section: Diseases and Oral Healthmentioning

confidence: 99%

Systemic Health Factors Related to Rapid Oral Health Deterioration Among Older People

Putten¹,

Baat²

2023

Preprint

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The oral health of older individuals can be negatively impacted by various systemic health factors, leading to rapid oral health deterioration. Older people are at risk of experiencing adverse reactions to medications due to multimorbidity, polypharmacy, and changes in pharmacokinetics and pharmacodynamics. Hyposalivation, a significant side effect of some medications, can be induced by both the type and number of medications used. Frailty, disability, sarcopenia, care dependency, and limited access to professional oral healthcare can also compromise the oral health of older people. To prevent rapid oral health deterioration, a comprehensive approach is required that involves effective communication between oral healthcare providers, other healthcare providers, and informal carers. Regardless of their health status, it is crucial to prioritize the well-being of older people. Oral healthcare providers have a responsibility to advocate for the importance of maintaining adequate oral health and to raise awareness of the serious consequences of weakened oral health. By doing so, we can prevent weakened oral health from becoming a geriatric syndrome.

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“…The trio of recurrent symptoms, aphthous stomatitis, genital ulcers, and iritis noted among native Mediterranean persons, were first described by the Turkish dermatologist, Hulusi Behçet in 1937 [3]. The prevalence of BD is considerably higher in regions near the Mediterranean Sea along the ancient Silk Route, including the Iberian Peninsula, Iran, Iraq, and Syria from the middle to the far east [1,2,4,5]. From an epidemiological perspective, BD has a global distribution.…”

Section: Introductionmentioning

confidence: 99%

“…From an epidemiological perspective, BD has a global distribution. Although its exact pathogenesis is a medical conundrum that has yet to be fully understood, studies suggest that it involves a complex interaction between environmental factors in genetically susceptible individuals leading to the autoimmune reactivity [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…BD is characterized as a chronic systemic inflammatory vasculitis primarily manifested by recurrent non-pathognomonic oral and genital ulcers, as well as skin lesions in the form of erythema nodosum, pseudofolliculitis, ocular lesions (anterior or posterior uveitis) (Table 1) [1][2][3][4][5]. Histopathological features play a crucial role in the differential diagnosis of BD.…”

Section: Introductionmentioning

confidence: 99%

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Oral Lesions as the Primary Manifestations of Behçet’s Disease: The Importance of Interdisciplinary Diagnostics—A Case Report

Soares

Pires

Quintanilha³

et al. 2023

Biomedicines

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Background: Behçet’s disease (BD) is a rare chronic auto-inflammatory systemic disease with non-specific oral manifestations, categorised as generalised variable vessel vasculitis that requires an interdisciplinary approach to diagnose due to its phenotypic heterogeneity. Whilst the oral lesions that reoccur in BD underpin the complex diagnostic process, the crucial role of dental professionals is highlighted in a case report summarised herein. We present a case of a 47-year-old male referred to the Oral Medicine Department by a rheumatologist after previous hospitalization for thrombosis of the iliac vein and inferior vena cava. He had elevated inflammatory C-reactive protein biomarker and an increased erythrocyte sedimentation rate. Recurrent episodes of folliculitis, oral and genital ulcers were reported. Clinical examination revealed multiple ulcerations in the oral mucosa. The complementary, histopathological analysis performed to rule out other disorders, based on excisional biopsy, showed non-keratinised stratified squamous epithelium with areas of exocytosis and ulceration. The connective tissue presented an intense mixed inflammatory infiltrate, congested blood vessels, haemorrhage, vasculitis, and HLA-B genotyping identified the expression of HLA-B15, further supporting the BD diagnosis. Treatment was initiated with colchicine, prednisolone, and weekly subcutaneous administration of methotrexate and resulted in the complete remission of oral lesions and no recurrence of other manifestations. Conclusions: This BD case report emphasizes the importance of a multidisciplinary approach in diagnosing BD, including the use of histopathological assessment and genetic profiling. It highlights the significance of thorough intraoral assessment and referral to a multidisciplinary team for diagnosis. The oral manifestations of BD as the primary symptoms often indicate underlying major systemic pathologies. The authors stress the need for a structured diagnostic algorithm to facilitate timely and effective management of BD.

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Effect of Behcet's disease‐associated oral ulcers on oral health related quality of life

Cited by 3 publications

References 31 publications

An Overview of Systemic Health Factors Related to Rapid Oral Health Deterioration among Older People

An Overview of Systemic Health Factors Related to Rapid Oral Health Deterioration among Older People

Systemic Health Factors Related to Rapid Oral Health Deterioration Among Older People

Oral Lesions as the Primary Manifestations of Behçet’s Disease: The Importance of Interdisciplinary Diagnostics—A Case Report

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