Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

Zhao, Jindong; Li, Yan; Sun, Min; Yu, Chanjuan; Li, Jiayun; Wang, Si-Hai; Yang, Daizhi; Guo, Chenglin; Du, Xue; Zhang, Wenjin; Cheng, Ruo-Dong; Diao, Xiao-Chuan; Fang, Zhaohui

doi:10.3748/wjg.v27.i8.708

Cited by 51 publications

(36 citation statements)

References 52 publications

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“…Notably, a recent study in diabetic Goto-Kakizaki rats showed that BBR improved metabolic parameters (including weight, FBG, GLP-1, and homeostatic model assessment-IR); however, the investigators observed significantly lower Bacteroidetes levels and B/F ratio, as well as decreased Muribaculaceae and increased Allobaculum levels. Further analysis showed a correlation between certain microbial communities and metabolic parameters (Zhao et al, 2021). As mentioned earlier, there is a crosstalk between the antidiabetic and antiobesity effects of BBR.…”

Section: Antidiabetic Effects Of Berberine By Regulating Gut Microbiotasupporting

confidence: 57%

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Yang

et al. 2021

Front. Pharmacol.

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Atherosclerosis (AS), especially atherosclerotic cardiovascular diseases (ASCVDs), and metabolic diseases (such as diabetes, obesity, dyslipidemia, and nonalcoholic fatty liver disease) are major public health issues worldwide that seriously threaten human health. Exploring effective natural product-based drugs is a promising strategy for the treatment of AS and metabolic diseases. Berberine (BBR), an important isoquinoline alkaloid found in various medicinal plants, has been shown to have multiple pharmacological effects and therapeutic applications. In view of its low bioavailability, increasing evidence indicates that the gut microbiota may serve as a target for the multifunctional effects of BBR. Under the pathological conditions of AS and metabolic diseases, BBR improves intestinal barrier function and reduces inflammation induced by gut microbiota-derived lipopolysaccharide (LPS). Moreover, BBR reverses or induces structural and compositional alterations in the gut microbiota and regulates gut microbe-dependent metabolites as well as related downstream pathways; this improves glucose and lipid metabolism and energy homeostasis. These findings at least partly explain the effect of BBR on AS and metabolic diseases. In this review, we elaborate on the research progress of BBR and its mechanisms of action in the treatment of AS and metabolic diseases from the perspective of gut microbiota, to reveal the potential contribution of gut microbiota to the multifunctional biological effects of BBR.

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Section: Antidiabetic Effects Of Berberine By Regulating Gut Microbiotasupporting

confidence: 57%

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Yang

et al. 2021

Front. Pharmacol.

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“…However, low bioavailability and an unidentified pharmacological mechanism are the main barriers to clinical application of berberine [ 27 ]. In addition to its pharmacological anti-diabetic roles in peripheral organs, it has been shown that berberine inhibits the function of disaccharide, promotes the release of GLP-1 to regulate metabolism, and modulates the component part of intestinal microbiota [ 28 ]. However, whether berberine could ameliorate intestinal glucose absorption received little attention.…”

Section: Discussionmentioning

confidence: 99%

Berberine Decreases Intestinal GLUT2 Translocation and Reduces Intestinal Glucose Absorption in Mice

Zhang

Yang

et al. 2021

IJMS

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Postprandial hyperglycemia is an important causative factor of type 2 diabetes mellitus, and permanent localization of intestinal GLUT2 in the brush border membrane is an important reason of postprandial hyperglycemia. Berberine, a small molecule derived from Coptidis rhizome, has been found to be potent at lowering blood glucose, but how berberine lowers postprandial blood glucose is still elusive. Here, we investigated the effect of berberine on intestinal glucose transporter 2 (GLUT2) translocation and intestinal glucose absorption in type 2 diabetes mouse model. Type 2 diabetes was induced by feeding of a high-fat diet and injection of streptozotocin and diabetic mice were treated with berberine for 6 weeks. The effects of berberine on intestinal glucose transport and GLUT2 translocation were accessed in isolated intestines and intestinal epithelial cells (IEC-6), respectively. We found that berberine treatment improved glucose tolerance and systemic insulin sensitivity in diabetic mice. Furthermore, berberine decreased intestinal glucose transport and inhibited GLUT2 translocation from cytoplasm to brush border membrane in intestinal epithelial cells. Mechanistically, berberine inhibited intestinal insulin-like growth factor 1 (IGF-1R) phosphorylation and thus reduced localization of PLC-β2 in the membrane, leading to decreased GLUT2 translocation. These results suggest that berberine reduces intestinal glucose absorption through inhibiting IGF-1R-PLC-β2-GLUT2 signal pathway.

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“…When these factors are abnormal, they can cause lipid metabolic disorders and pathophysiological changes in the related organs, hyperlipoproteinemia, lipidosis, and the resulting clinical syndromes, such as obesity, ketoacidosis, fatty liver, and neonatal scleredema ( 20 ). Statins are commonly used drugs for the treatment of dyslipidemia, but such drugs may bring many adverse effects, such as liver and kidney dysfunction, abnormal neuromuscular responses, increased risk of diabetes, and cognitive decline ( 21 ). Accumulating evidence suggests that gut flora structure is closely related to the development of lipid metabolism disorders ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Chinese Herbal Preparations Regulating Intestinal Flora on Lipid Metabolism Disorders in Patients: A Meta-Analysis of Controlled Clinical Studies

2022

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BackgroundLipid metabolism disorders can damage human health, and the changes in human intestinal flora are closely related to lipid metabolism disorders. Traditional Chinese medicine (TCM) can play a role in regulating intestinal flora and balancing intestinal microecology. In this meta-analysis, the role of oral preparations of TCM that regulate intestinal flora, in the prevention and treatment of lipid metabolism disorders, was systematically evaluated.MethodsThe databases CBM, Pubmed, Embase, CNKI, Wanfang, and Google Scholar were searched by rapid matching of keywords to obtain clinical controlled studies related to oral preparations of TCMs regulating intestinal flora. After screening and quality evaluation, meta-analysis was performed using Review Manager 5.3 software.ResultsTotal of 835 patients were enrolled in the 10 articles included in this study. Meta-analysis showed that TCM intervention could reduce the level of total cholesterol (TC) in patients with abnormal lipid metabolism [mean difference (MD) = −0.61, 95% confidence interval (95%CI) (−0.80, −0.42), p < 0.00001], reduce triacylglycerol (TG) level [MD = −0.46, 95%CI (−0.60, −0.33), p < 0.00001], increase high-density lipoprotein (HDL) level [MD = 0.25, 95%CI (0.17, 0.34), p < 0.00001], reduce the number of intestinal enterobacteria [MD = −0.64, 95%CI (−0.79, −0.49), p < 0.00001], reduce the number of enterococci [MD = −1.14, 95%CI (−1.66, −0.63), p < 0.00001], increase the number of intestinal lactobacillus [MD = 0.41, 95%CI (0.09, 0.74), p = 0.01], and increase the number of intestinal bifidobacteria [MD = 0.94, 95%CI (0.20, 1.68), p = 0.01].ConclusionThe application of oral preparations of TCMs that regulate intestinal flora, in the prevention and treatment of lipid metabolism disorders, can increase the colonization of beneficial bacteria in the intestine of patients, inhibit the growth of harmful bacteria, and restore the intestinal microecological balance, thus indirectly acting on the regulation of blood lipids in patients and contributing to the recovery of dyslipidemia.

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Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

Cited by 51 publications

References 52 publications

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Berberine Decreases Intestinal GLUT2 Translocation and Reduces Intestinal Glucose Absorption in Mice

Effect of Oral Chinese Herbal Preparations Regulating Intestinal Flora on Lipid Metabolism Disorders in Patients: A Meta-Analysis of Controlled Clinical Studies

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