1983
DOI: 10.1136/hrt.49.1.83
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Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging.

Abstract: Nine patients with stable angina (group 1) underwent maximal treadmill stress testing and thallium-201 (201T1) myocardial scintigraphy after intravenous propranolol hydrochloride, and after placebo. Though seven of the nine patients exercised longer after propranolol than after placebo, this difference did not reach statistical significance. Propranolol, however, significantly reduced the mean maximum rate pressure product. Comparison of the perfusion scans on and off propranolol showed that in 36 out of 90 of… Show more

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Cited by 42 publications
(7 citation statements)
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“…Nonrandomized studies compared the exercise MPI results of patients on with those not on BB therapies. However, these studies were in different groups of patients and overall showed a decrease in the sensitivity in detecting CAD in patients on BBs (50,51).…”
Section: Bbsmentioning
confidence: 87%
See 1 more Smart Citation
“…Nonrandomized studies compared the exercise MPI results of patients on with those not on BB therapies. However, these studies were in different groups of patients and overall showed a decrease in the sensitivity in detecting CAD in patients on BBs (50,51).…”
Section: Bbsmentioning
confidence: 87%
“…The patients exercised to the same work load before and after treatment, although their heart rates were lower (53). Intravenous propranolol administration to patients undergoing exercise MPI also decreased the perfusion defect size compared with placebo (50); the reduction in defect size was noted in the subgroup of patients who achieved the same double product with propranolol, suggesting that the effect may not entirely be related to the reduction in myocardial oxygen demand (50).…”
Section: Bbsmentioning
confidence: 94%
“…The intensity of stress is also a confounding factor and several studies have shown that sensitivity is related to the intensity of exercise [ 14 , 23 , 84 ]. Anti-angina medication reduces sensitivity using dynamic exercise [ 85 , 86 ] and medication should ideally be discontinued before diagnostic studies [ 87 ]. It is less clear whether medication reduces diagnostic sensitivity using vasodilator stress but reduced sensitivity has been observed [ 88 ].…”
Section: Diagnosismentioning
confidence: 99%
“…Images improved significantly after propranolol. Hockings et al (1983) also reported a significant reduction of the extent of perfusion defects after propranolol infusion compared to placebo. It was concluded that in patients on propranolol, negative results do not exclude coronary artery disease.…”
Section: Discussionmentioning
confidence: 89%