1998
DOI: 10.1006/exer.1998.0495
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Effect of Betaxolol, Timolol and Nimodipine on Human and Pig Retinal Arterioles

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Cited by 59 publications
(17 citation statements)
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“…42,43 There have been several reports suggesting the beneficial effects of topical betaxolol on the retinal, optic nerve head or retrobulbar circulation in humans, [44][45][46][47] and Yu et al found that betaxolol at concentrations higher than 10 Ϫ12 M caused dilation of endothelin-1 preconstricted, isolated, and perfused human retinal arterioles. 48 Taken together with these previous findings, the possible relation of the vascular effects of betaxolol to the present findings cannot be ruled out. Several in vitro studies have demonstrated the neuroprotective effects of betaxolol at relatively high concentrations.…”
Section: Discussionsupporting
confidence: 45%
“…42,43 There have been several reports suggesting the beneficial effects of topical betaxolol on the retinal, optic nerve head or retrobulbar circulation in humans, [44][45][46][47] and Yu et al found that betaxolol at concentrations higher than 10 Ϫ12 M caused dilation of endothelin-1 preconstricted, isolated, and perfused human retinal arterioles. 48 Taken together with these previous findings, the possible relation of the vascular effects of betaxolol to the present findings cannot be ruled out. Several in vitro studies have demonstrated the neuroprotective effects of betaxolol at relatively high concentrations.…”
Section: Discussionsupporting
confidence: 45%
“…The vasoactive effects of sodium fluorescein seen in the current study are therefore observed with sodium fluorescein levels considerably lower than that expected in fluorescein angiography. As we have previously demonstrated comparable vasoactive effects of other agents in pig and human vessels, 16,17 it may be reasonable to expect sodium fluorescein to have contractile effects on human vessels. If this is the case, then reducing illumination level may limit any vasoconstrictive effects of sodium fluorescein when used in routine ophthalmic examinations.…”
Section: Discussionmentioning
confidence: 91%
“…Yu et al showed that ET-1 dose causes constriction even in cryopreserved human retinal arterioles. But the relation between the dose and the related activity is still not known (Yu, et al, 1998). Thus, in this method there is no problem regarding inflammation or infection.…”
Section: Endothelin Administrationmentioning
confidence: 99%