Effect of betel chewing, tobacco smoking and alcohol consumption on oral submucous fibrosis: a case–control study in Sri Lanka

Ariyawardana, Anura; Athukorala, A. D. S.; Arulanandam, A.

doi:10.1111/j.1600-0714.2006.00400.x

Cited by 65 publications

(53 citation statements)

References 17 publications

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“…The habit of betel quid chewing is implicated in the high prevalence of oral cancer in these countries. Betel quid consists of a mixture of fresh areca nut, slaked lime from seashells, fresh betel leaf and partially dried tobacco (2)(3)(4). The association of these components with oral carcinogenesis remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline

et al. 2017

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Abstract. Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed. The HGEPs were alternated between 3 days of incubation with arecoline (50 µg/ml), and 3 days without arecoline, for up to 30 days. The expression levels of the MMPs and TIMPs in the cells stimulated with arecoline were evaluated by reverse transcription-quantitative polymerase chain reaction at 18 and 30 days. The expression of MMP-9 mRNA in the experimental group was significantly increased compared with in the control group (P<0.01). No significant differences in the expression of MMP-2, TIMP-1 or TIMP-2 mRNA were observed between the experimental and control groups. Using an MMP-9 activity assay, the levels of MMP-9 activity in the experimental group were demonstrated to be significantly higher than in the control group (P<0.05). To investigate associated cellular signaling pathways, PDTC [a nuclear factor (NF)-κB/inhibitor of NF-κB (IκB) inhibitor], PD98059 [a mitogen-activated protein kinase kinase (MAPKK)1 and MAPKK2 inhibitor], SB203580 (a p38 MAPK inhibitor) and 5,15-DPP [a signal transduction and activator of transcription (STAT) 3 inhibitor] were used. All inhibitors decreased the extent of MMP-9 upregulation induced by stimulation with arecoline. Based on the data, it is hypothesized that MMP-9 activity may be involved in the pathological alterations of oral epithelium induced by betel quid chewing, and that the NF-κB/IκB, MAPK, p38 MAPK and STAT3 signaling pathways may be involved in the production of MMP-9 induced by betel quid chewing.

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Section: Introductionmentioning

confidence: 99%

Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline

et al. 2017

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“…The disease is most common in persons aged 20-40 years with a peak incidence of 29.09 years (4) and male: female ratio of 34:1 (7). It is a collagen disorder which leads to fibroelastic changes in the oral mucosa leading to limited access to the oral cavity, and it compromises oral hygiene and even food intake (1). Onset of OSMF is insidious over a 2-5 year period (8).…”

Section: Introductionmentioning

confidence: 99%

“…Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent (1)(2)(3). The prevalence rate of OSMF in India is considered to be 0.2-0.5% (4).…”

Section: Introductionmentioning

confidence: 99%

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

2011

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“…It has been shown that Masseter Muscle thickness increases as the duration and frequency of the habit increase (12) . Thick inelastic circumoral fibrous bands around the entire circle of lips could result in thinning of lips and narrowing of rimaoris leading to difficulty in mouth opening (13) . The other findings of exaggerated malar prominence, multiple shallow nasolabial folds and Pseudo-proptosis (appearance of bulged eyeballs) were relatively uncommon in our series, but nevertheless we believe that when these features are present together in a patient without concomitant systemic disorders, the diagnosis of Gutkafacies is highly likely.…”

Section: Discussionmentioning

confidence: 99%

Gutka Facies in Oral Submucous Fibrosis – A Cross Sectional Study in Chennai

MD¹

2017

JMSCR

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Effect of betel chewing, tobacco smoking and alcohol consumption on oral submucous fibrosis: a case–control study in Sri Lanka

Abstract: The present study has shown a strong association of betel quid chewing (including tobacco as an ingredient) with the causation of OSMF.

Cited by 65 publications

References 17 publications

Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline

Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

Gutka Facies in Oral Submucous Fibrosis – A Cross Sectional Study in Chennai

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