Effect of Bilayer Phase Transitions on Vesicle Structure, and its Influence on the Kinetics of Viologen Reduction

Andersson, Mikael; Hammarström, Leif; Edwards, Katarina

doi:10.1021/j100039a047

Cited by 106 publications

(108 citation statements)

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“…Therefore, our results have to be regarded as a first approximation. In previous findings, the faceting of otherwise smooth, rounded vesicles, seemed to occur when the lipids constituting the bilayer were below the gel (L β ) to fluid (L α ) transition temperature [34][35][36][37] and to be produced by the induction of asymmetry in rigid bilayer domains with ordering in the plane of the bilayer [38]. From the analysis of the WAXS domains of our formulations, the presence of a weak peak at around 1.52 Å -1 was noticed, which coincides with the peak attributed to L β or L β' ( Figure 2E, F) [39].…”

Section: Vesicle Characterizationmentioning

confidence: 83%

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Castangia

Manca

Caddeo

et al. 2015

Colloids and Surfaces B: Biointerfaces

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The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.Santolina insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or 2 propylene glycol were added to the water phase (10% v/v) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering, cryogenic transmission electron microscopy and small/wide-angle X-ray scattering, the results showing polyhedral, faceted, unilamellar vesicles of ~115 nm in size. The presence of the glycols improved vesicle stability under accelerated ageing conditions, without changes in size or migration phenomena (e.g., sedimentation and creaming). Confocal laser scanning microscopy images of pig skin treated with Santolina insularis formulations displayed a penetration ability of PEVs greater than that of control liposomes. Moreover, all formulations showed a marked in vitro biocompatibility in human keratinocytes.These findings suggest that the nanoformulation may be of value in enhancing the delivery of Santolina insularis essential oil to the skin, where it can exert its biological activities.

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Section: Vesicle Characterizationmentioning

confidence: 83%

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Castangia

Manca

Caddeo

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…1) allows the formation of different structural ensembles in aqueous solutions: large vesicles are produced by chloroform vaporization (Carmona-Ribeiro and Chaimovich 1983) or heating above the phase transition temperature (Tsuruta et al 1997); small open bilayer fragments (or bicelles) are produced by sonication (Pansu et al 1990;Andersson et al 1995;Benatti et al 2001). Vesicle sizes were found to be highly polydisperse.…”

Section: Detecting Dodab Bicelles By Esrmentioning

confidence: 99%

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

et al. 2017

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Cationic bilayers have been used as models to study membrane fusion, templates for polymerization and deposition of materials, carriers of nucleic acids and hydrophobic drugs, microbicidal agents and vaccine adjuvants. The versatility of these membranes depends on their structure. Electron spin resonance (ESR) spectroscopy is a powerful technique that employs hydrophobic spin labels to probe membrane structure and packing. The focus of this review is the extensive structural characterization of cationic membranes prepared with dioctadecyldimethylammonium bromide or diC14-amidine to illustrate how ESR spectroscopy can provide important structural information on bilayer thermotropic behavior, gel and fluid phases, phase coexistence, presence of bilayer interdigitation, membrane fusion and interactions with other biologically relevant molecules.

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“…All liposomes exhibited size constriction at 40 , both during the heating and cooling cycles, which correspond to the chain melting temperature of the phospholipid bilayer to be explained later during the DSC studies . Phospholipid bilayers undergo a change from highly ordered gel phase to a fluid phase 42 , resulting in size constriction. It is proposed that because of chain melting, the mutual miscibility among the lipidic components will increase, thereby reducing packing defects.…”

Section: Dls Studiesmentioning

confidence: 99%

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

et al. 2016

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Effect of Bilayer Phase Transitions on Vesicle Structure, and its Influence on the Kinetics of Viologen Reduction

Cited by 106 publications

References 1 publication

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

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