Effect of bile acids on the biliary excretion of pravastatin in rats

Morisawa, Yoshihiko; Takikawa, Hajime

doi:10.1111/j.1872-034x.2009.00493.x

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…The bile ducts have been cannulated as described in many works [24][25][26]. In one ank, about 0.5 µCi of radioactive Se in physiological saline was subcutaneously injected, and the participating element was given in the opposite ank.…”

Section: Methodsmentioning

confidence: 99%

Comparative Study of the Biochemical Behavior of some Highly Toxic Minerals on Selenosis in Rats

Aljerf¹,

Williams²,

Ajong³

et al. 2020

Preprint

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Objective: An investigation of the potential influences of As, Hg, Tl and Pb on Se metabolism, which can suggest new drugs to cope the poisonousness of Se. Methods: Chronic cases were carried out with the nursing of rats with a purified diet of water-soluble vitamin mix, fat-soluble vitamin mix, saccharides, oil, and salts. One week after the basic diet, the rats taken Se have received diets containing 10 ppm of the element as sodium selenite or selenate added in the salts. Result: As, Hg, and Tl were repressed the volatized Se excreted from the lungs. As has assisted the biliary excretion of Se and inhibited the chronic selenosis. Tl has increased the retention of Se in the liver and kidney, but, had no chronic effect on the amount of Se deposited in all the studied tissues. Similarly, Hg has increased the retention of Se but in the spleen and carcass of rats indicating to the high Se concentration in blood. Hg and Tl have inhibited the Se in urine. Conclusion: No effects of the doses rich in As, Hg, and Tl on the Se excretion in fecal. Even though, we suggest As as a possible medication to chronic selenosis.

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Section: Methodsmentioning

confidence: 99%

Comparative Study of the Biochemical Behavior of some Highly Toxic Minerals on Selenosis in Rats

Aljerf¹,

Williams²,

Ajong³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Animals were anesthetized with an intraperitoneal injection of pentobarbital (5 mg/100 g), and the common bile duct was cannulated with a PE‐10 tubing (Becton Dickinson, Sparks MD) after laparotomy. The femoral vein was cannulated with a 3‐Fr venous catheter, and was infused with 3% human serum albumin in a 5% glucose solution (standard solution) at the rate of 2 mL/hr during the experiment 38 . E17G, LCG, VLB and EM dissolved in the standard solution were administered intravenously as described below.…”

Section: Methodsmentioning

confidence: 99%