This paper presents an investigation on the combustion performance of different Coconut Methyl Ester (CME) biodiesel blends with Conventional Diesel Fuel (CDF) under B5 (5% CME, 95% CDF), B15 (15% CME, 85% CDF), and B25 (25% CME, 75% CDF) conditions. The performances of these fuels were evaluated based on the temperature profiles of the combustor wall and emission concentration of Oxides of Nitrogen (NO x ), Sulphur Dioxide (SO 2 ), and Carbon Monoxide (CO). The fuel properties of the CME biodiesel blends were measured and compared with CDF. All tested fuels were combusted using an open-ended combustion chamber at three different equivalence ratios, i.e., lean fuel to air mixture (Φ = 0.8), stoichiometry (Φ = 1.0), and rich fuel to air mixture (Φ =1.2), using a standard solid spray fuel nozzle. The results indicated that CME biodiesel blends combust at a lower temperature and produce less emission in comparison with CDF for all equivalence ratios. Moreover, the increase of CME content in biodiesel blends reduced the temperature of the combustor wall and the emission concentration. Results also proved that the utilization of biodiesel is beneficial to various industrial applications, especially in the transportation sector due to it being environmentally friendly, and serves as an alternative to petroleum diesel fuel.