The large-scale production of platform chemicals from
biomass requires
efficient, cost-effective, and sustainable methods. Here, we present
three one-pot synthesis routes for producing diformylxylose (DFX),
a sugar-based solvent and platform chemical, using d-xylose
or corncobs as feedstocks. With yields of approximately 80%, these
routes were seamlessly scaled from lab to kilogram-scale in a 15 L
batch reactor. Techno-economic assessment demonstrates the competitiveness
of the proposed methods against fossil- and biobased analogues. Life-cycle
analysis shows the potential of these processes to reduce environmental
and societal impacts from cradle to gate. At the “end of life”,
DFX is demonstrated to be inherently biodegradable. Overall, we present
a compelling case study of scaling a novel platform chemical guided
by techno-economic and environmental concerns leading to balanced
cost-competitiveness and life-cycle sustainability.