Effect of birth weight on adulthood renal function: A bias‐adjusted meta‐analytic approach

Das, Sumon Kumar; Mannan, M A; Faruque, Abu Syed Golam; Ahmed, Tahmeed; McIntyre, H. David; Mamun, Abdullah Al

doi:10.1111/nep.12732

Cited by 40 publications

(29 citation statements)

References 88 publications

(518 reference statements)

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“…Analysis of the collected findings indicated that very LBW (<1500g) individuals had a greater subsequent risk for development of CKD, determined by albumin/protein excretion, serum creatinine level, creatinine clearance, GFR or presence of ESRD, compared to normal birth weight counterparts (25). Das et al noted similar findings in a study published in 2016 (24). In this systemic review and meta-analysis of studies published prior to September 2015, LBW was associated with lower GFR (24).…”

Section: Epidemiological Studies Linking Birth Weight and Renal DIsupporting

confidence: 72%

“…Das et al noted similar findings in a study published in 2016 (24). In this systemic review and meta-analysis of studies published prior to September 2015, LBW was associated with lower GFR (24). In addition, over one third of those with diabetes had LBW and CKD, defined by GFR and the microalbuminuria/albumin excretion rate ( AER ) /urinary albumin creatinine ratio ( ACR ) (23).…”

Section: Epidemiological Studies Linking Birth Weight and Renal DIsupporting

confidence: 72%

“…Numerous epidemiological and experimental studies focus on the link between IUGR of different origins and the chronic health outcomes of offspring in later life. Brenner (10) and others (24, 25, 26) have applied this hypothesis to the etiology of kidney disease. Like Barker, Brenner postulated that IUGR leads to a redistribution of nutrient delivery to supply essential tissues during development at the expense of organs like the kidney which typically have a high functional reserve (10).…”

Section: Introductionmentioning

confidence: 99%

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Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease

Newsome

Davis

Ojeda

et al. 2017

Expert Review of Cardiovascular Therapy

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Introduction Numerous epidemiological studies indicate an inverse association between birth weight and the risk for chronic kidney disease. Areas covered Historically, the first studies to address the developmental origins of chronic disease focused on the inverse relationship between birth weight and blood pressure. A reduction in nephron number was a consistent finding in low birth weight individuals and experimental models of developmental insult. Recent studies indicate that a congenital reduction in renal reserve in conjunction with an increase in blood pressure that has its origins in fetal life increases vulnerability to renal injury and disease. Expert commentary Limited experimental studies have investigated the mechanisms that contribute to the developmental origins of kidney disease. Several studies suggest that enhanced susceptibility to renal injury following a developmental insult is altered by sex and age. More in-depth studies are needed to clarify how low birth weight contributes to enhanced renal risk, and how sex and age influence this adverse relationship.

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Section: Epidemiological Studies Linking Birth Weight and Renal DIsupporting

confidence: 72%

Section: Epidemiological Studies Linking Birth Weight and Renal DIsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease

Newsome

Davis

Ojeda

et al. 2017

Expert Review of Cardiovascular Therapy

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“…However, another two studies revealed no difference in telomere length according to newborn birthweight (Akkad et al, 2006;Entringer, Epel, Lin, Blackburn, Buss, Shahbaba, et al, 2015;Entringer, Epel, Lin, Blackburn, Buss, Simhan, et al, 2015). Short telomere lengths are associated with increased risks of chronic diseases in adults (Agmon-Levin et al, 2013;Ma et al, 2011;Wang, 2016), and a low birthweight (<2,500 g) increases the risk of chronic diseases such as chronic kidney disease (Das et al, 2016), asthma (Xu et al, 2014), and coronary heart disease (Wang et al, 2014) (Ramakrishnan, Imhoff-Kunsch, & Martorell, 2014). A recent meta-analysis concluded that providing nutritional advice or balanced energy and protein supplements to pregnant women may be beneficial (Ota, Hori, Mori, Tobe-Gai, & Farrar, 2015).…”

Section: Discussionmentioning

confidence: 99%

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns

Kim

Lee

et al. 2017

Maternal & Child Nutrition

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Gestational vitamin D insufficiency is related with increased risks of various diseases and poor health outcomes later in life. Telomere length at birth or early in life is known to be a predictor of individual health. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women.We investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. This cross-sectional study included 106 healthy pregnant women without adverse obstetric outcomes and their offspring. We examined the maternal age, weight before pregnancy, health behaviours, and nutritional intakes, along with each newborn's sex and birthweight, and we measured maternal height, telomere length, total white blood cell count, and glycosylated haemoglobin as covariates. Pearson's correlation coefficients were calculated to evaluate the relationship between the baseline variables and newborn leukocyte telomere lengths. To confirm that there was an independent association between newborn leukocyte telomere lengths and maternal vitamin D concentrations, we performed a stepwise multiple linear regression analysis. Newborn leukocyte telomere lengths correlated positively with maternal leukocyte telomere lengths (r = .76, p < .01), maternal 25-hydroxyvitamin D concentrations (r = .72, p < .01), maternal energy intakes (r = .22, p = .03), and newborn body weights (r = .51, p < .01). In the multivariate model, newborn leukocyte telomere lengths were associated with maternal vitamin D concentrations (β = .33, p < .01). These findings suggest that the maternal vitamin D concentration during pregnancy may be a significant determinant of the offspring's telomere length.

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“…There is evidence that low nephron number is associated with renal disease in adulthood, [8][9][10][11] with a multitude of animal studies identifying that a 20%-30% reduction in nephron number is important. [12][13][14][15] Precise and accurate estimation of nephron number by noninvasive methods is not currently feasible, although a direct relation between foetal weight and kidney size, 16 birth weight and kidney function, 17,18 and between kidney mass and total nephron number 19,20 has been reported. As renal mass is proportional to renal volume in infants, kidney volume is currently considered a surrogate measure of nephron number.…”

Section: Introductionmentioning

confidence: 99%

Normal foetal kidney volume in offspring of women treated for gestational diabetes

Hokke

Zoysa

Carr

et al. 2019

Endocrino Diabet & Metabol

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Aims The worldwide prevalence of gestational diabetes mellitus (GDM) is increasing. Studies in rodent models indicate that hyperglycaemia during pregnancy alters kidney development, yet few studies have examined if this is so in humans. The objective of this study was to evaluate the association of treated GDM with foetal kidney size. Materials and Methods Participants were recruited from an Australian tertiary hospital, and clinical data were collected from women without GDM and women diagnosed and treated for GDM and their offspring. Participants underwent an obstetric ultrasound at 32‐34 weeks gestation for foetal biometry and foetal kidney volume measurement. Results Sixty‐four non‐GDM and 64 GDM women participated in the study. Thirty percent of GDM women were diagnosed with fasting hyperglycaemia, while 89% had an elevated 2‐hour glucose level. Maternal age, weight and body mass index were similar in women with and without GDM. Estimated foetal weight, foetal kidney dimensions, total foetal kidney volume and birth weight were similar in offspring of women with and without GDM. Conclusions We conclude that a period of mild hyperglycaemia prior to diagnosis of GDM and treatment initiation, which coincides with a period of rapid nephron formation and kidney growth, does not alter kidney size at 32‐34 weeks gestation.

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Effect of birth weight on adulthood renal function: A bias‐adjusted meta‐analytic approach

Cited by 40 publications

References 88 publications

Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease

Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns

Normal foetal kidney volume in offspring of women treated for gestational diabetes

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