Effect of Bitters on the Body Weight, Lipid Profile, Catalase and Lipid Peroxidation in Experimental Animals

Alabi, Mutiu A.; Sunday, Rita Maneju; Olowokere, T.; Kareem, Fatai A.; Osanaiye, F.

doi:10.3923/jms.2013.62.66

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…These findings are in line with the reports of [20]. Anionye et al [20], also reported According to Alabi et al [5], phenolic compounds and flavonoids present in plant extracts enhances hepatoprotective activities and not necessarily derangements by preventing oxidative stress. Alabi et al [5], further reported that administration herbal Bitters drugs at the dose of 15 ml/kg bodyweight reduced lipid peroxidation and oxidative stress in experimental animals.…”

Section: Discussionsupporting

confidence: 93%

“…Anionye et al [20], also reported According to Alabi et al [5], phenolic compounds and flavonoids present in plant extracts enhances hepatoprotective activities and not necessarily derangements by preventing oxidative stress. Alabi et al [5], further reported that administration herbal Bitters drugs at the dose of 15 ml/kg bodyweight reduced lipid peroxidation and oxidative stress in experimental animals. Also, a study by Udenze et al [4] revealed that treatment with kolaviron, a major component of Garcinia kola (a constituent of action bitters), did not affect hepatic marker indices.…”

Section: Discussionmentioning

confidence: 99%

“…These products were made from fermentation of honey (meads), fruits and berries (wines) and those from cereals were the first beers [3,4]. These beverages were known, accepted and prized as foods, as magic fluids and as medicines [5] until the 19 th and early 20 th century when there was a steady decline in the therapeutic use of herbal medicine. Plants serves as a basic for medical treatment and their different parts have been a source of herbal medicine which has been shown to be effective to about 80% of population as primary healthcare [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Effect of Action Bitters (Herbal Mixture) on Some Biochemical Indices of Albino Rats

Nwachuku

Elekima

2019

AJRB

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Aim: The aim of the study was to evaluate the effect of action bitters on some liver and renal function indices of Albino rats. Study Design: Experimental rats were divided into two groups A and B. Group A (control rats) consist of 10 rats and were not given herbal drugs while group B (treated rats) consist of 25 rats and were treated orally with 0.68 ml/kg of Action Bitters on a daily basis for 30 days. Place and Duration of Study: The experiment was carried out in the Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria within a period of four months (July 2018 – October, 2018). Methodology: A total of 35 male albino rats weighing an average of 0.18 kg were separated into two groups namely A and B. Group A had 10 rats and were used as control while Group B had 25 rats and were treated as the test group. Group A rats were fed normally while Group B received water, rat feds and Action Bitters. The action bitters were administered orally using galvage tube at a dose of 0.68/kg bodyweight. After 30th day of treatment, blood samples were collected for analysis of serum Electrolytes, Urea, Creatinine, AST, ALP and ALT. The biochemical parameters were analysed statistically using GraphPad Prism 5.03 version. Results: Results of renal indices obtained showed that control rats had values of 9.567±6.396, 74.59±40.93, 153±25.67, 111.7±20.23 and 5.767±1.819 for Urea, Creatinine, Potassium, Sodium and Chloride respectively while the treated rats had 11.72±6.142, 122.9±82.16, 152.8±27.57, 116.6±24.98 and 6.156±1.843 for Urea, Creatinine, Potassium, Sodium and Chloride respectively. More so, when liver enzymes were considered, control rats had values of 134.2 ± 52.07, 35.44± 13.82 and 169.2± 71.92 for AST, ALT and ALP respectively while treated rats had values of 139.4 ±44.6, 35.39± 14.39 and 196.9± 65.92 for AST, ALT and ALP respectively. The comparison of control rats and treated rats showed no significant differences in the biochemical indices considered at P=.05. Conclusion: The study indicated that Action Bitters did not induce any obvious biochemical derangement in liver and renal indices at a dose of 0.68ml/kg bodyweight.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Effect of Action Bitters (Herbal Mixture) on Some Biochemical Indices of Albino Rats

Nwachuku

Elekima

2019

AJRB

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“…For instance, they found out that; these polyherbal medicines have high percentage MDA inhibition in a concentration dependent manner. MDA, the product of lipid peroxidation, is an index of the level of oxygen free radicals [30]. Therefore, this observed decrease in hepatic MDA levels in almost all treatments when compared with the control is an indication of prevention of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 86%

Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

Emaleku¹

2018

J Stem Cell Res Ther

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Objective: Plants and their derived products have served as veritable sources of foods and medicines for humans and animals from the outset, and the emergency of polyherbs (plants-derived products) in recent years has received the widest publicity and patronage by the Nigerian population as alternative medicines. It is not over statement to say many of them lack empirical data or validation to support the upsurge and prevalence in their usage as folk medicines, and little or no scientific data exist on their potential side effects. This study therefore investigates "the effects of some of these polyherbal drugs on hepatic antioxidants in experimental rats". Methods: Eight of the nine groups containing five animals each used for this study were administered eight different polyherbal drugs following different manufacturer's recommended dosage, while the ninth group served as control with no polyherb treatment. The study lasted for seven weeks i.e. forty-nine days, and on the 50th day, the animals were sacrificed after 12 h of previous overnight fasting, and their livers were excised for antioxidant assays. Results: Fidson bitters and Asheitu Adams blood purifier (ABP) significantly decreased superoxide oxidase (SOD) and glutathione-S-transferase (GST), while Yoyo bitter and Asheitu Adams formula for diabetes (AD) mostly decreased reduced glutathione (GSH) in a non-significant manner at (p<0.05). Conclusion: All polyherbal medicines caused depletion of hepatic antioxidant enzymes (SOD and GST), which is an indication of oxidative stress condition, but some of them improved non-enzymatic antioxidants like malondialdehyde (MDA) and vitamin C.

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“…Bitters contain complex carbohydrates, secondary metabolites, vitamins and minerals that have antioxidant, antiviral and other pharmacological properties. They are used to aid digestion and metabolism, relieve occasional heartburn, calm upset stomach and nausea, increase absorption of fat soluble vitamins, help maintain healthy blood sugar levels, ease constipation and regulate bowel movements, help mop up free radicals and stimulate immune function among others [4] [5]. Its use is common among patients with chronic diseases like hypertension and diabetes [6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Yoyo Bitters on the Dissolution of Metformin Tablets

Igbokwe

Muazu

2017

JAPLR

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Background: Yoyo bitters is an oral poly herbal liquid preparation popularly marketed and used in Nigeria. Its use is rapidly increasing among patients with chronic diseases such as diabetes and hypertension. This is because it has been claimed to regulate blood pressure, control body weight, and facilitate digestion among others. Metformin is an oral anti diabetic agent. Both the incidences of Diabetes and use of Yoyo bitters are increasing hence setting the stage for possible co-administration of these two agents. This also increases the potential for Herb-drug interaction. The aim of the study is to investigate the effect of Yoyo bitters on the dissolution of metformin tablets.Methods: Physicochemical tests (Weight uniformity, Crushing strength, Friability and Assay) were carried out on two different brands of metformin tablets and physical properties of the Yoyo bitters were also determined. The in-vitro dissolution of metformin tablets with and without Yoyo bitters in dissolution media was then carried out at pH 1.2, 4.5 and 6.8 using United States Pharmacopoeia (USP) apparatus 1 (basket) at 100rpm with 900ml of the dissolution medium (sink condition) maintained at a steady temperature of 37±0.5ºC. Two different brands metformin 500mg immediate release tablets were used and the analysis was done using UVSpectrophotometer at a wavelength of 232nm. Results:The results obtained show that at pH 1.2, the percentage amount of metformin released decreased significantly in the presence of Yoyo bitters for both brands (p=0.002 and p=0.013 respectively). At pH 4.5 there was no significant difference in metformin released for the Diabetmin ® (p=0.196) and a significant difference was observed with Sandoz ® (p=0.045). At pH 6.8, a significant decrease in percentage metformin released in the presence of Yoyo bitters was observed for both brands (p=0.011 and p=0.044 respectively). Conclusion:Yoyo bitters decreased the dissolution of metformin tablets at pH 1.2, 4.5 and 6.8. Due to therapeutic failure, toxicity etc caused by decreased dissolution, concomitant use of metformin and Yoyo bitters should be discouraged.

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Effect of Bitters on the Body Weight, Lipid Profile, Catalase and Lipid Peroxidation in Experimental Animals

Cited by 5 publications

References 8 publications

Evaluation of the Effect of Action Bitters (Herbal Mixture) on Some Biochemical Indices of Albino Rats

Evaluation of the Effect of Action Bitters (Herbal Mixture) on Some Biochemical Indices of Albino Rats

Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

The Effect of Yoyo Bitters on the Dissolution of Metformin Tablets

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