Effect of Blasting Treatments on the Surface Topography and Cell Adhesion on Biodegradable FeMn‐Based Stents Processed by Laser Powder Bed Fusion

Paul, Birgit; Hofmann, Anja; Weinert, Sönke; Frank, Frieda; Wolff, Ulrike; Krautz, Maria; Edelmann, Jan; Gee, Michael W.; Reeps, Christian; Hufenbach, J.

doi:10.1002/adem.202200961

Cited by 7 publications

(7 citation statements)

References 66 publications

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“…Many surface treatment methods currently exist, including chemical methods [ 68 ] and physical methods [ 69 ]. Physical methods consist of milling [ 70 ], laser [ [71] , [72] , [73] ], sandblasting [ 74 , 75 ], and electrical discharge machining (EDM) [ 76 , 77 ], while chemical methods include acid [ 78 ] and alkali treatment [ 79 , 80 ], nitriding [ 81 , 82 ], and plasma treatment [ 83 , 84 ]. In addition, some electrochemical methods are available, such as electropolishing [ 85 , 86 ], electrolytic polishing [ 87 , 88 ], anodic oxidation [ 89 , 90 ], and micro-arc oxidation (MAO, also known as plasma electrolytic oxidation) [ 80 , 91 ].…”

Section: Methods To Improve the Biocompatibility Of Materialsmentioning

confidence: 99%

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

Duan,

Yang,

Zhang

et al. 2024

Heliyon

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Section: Methods To Improve the Biocompatibility Of Materialsmentioning

confidence: 99%

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

Duan,

Yang,

Zhang

et al. 2024

Heliyon

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“…However, as those materials should release Cu ions as they degrade, lower Cu contents would be sufficient. Besides Mg-based , and Zn-based, Fe-based alloys − are also widely investigated for the use as temporary implant material with high potential for future clinical application. Regarding degradable Fe-based implant materials, only a few studies investigate the alloying with Cu.…”

Section: Introductionmentioning

confidence: 99%

“…These FeMn-based alloys are more favorable than Fe-based alloys due to their good processability combined with enhanced strength and a higher in vitro degradation rate. They were tested as potential material for bone, cardiovascular, and urinary applications. ,,, …”

Section: Introductionmentioning

confidence: 99%

“…They were tested as potential material for bone, cardiovascular, and urinary applications. 30,37,39,40 In vitro corrosion mechanisms are quite well understood for FeMn-based alloys in chloride-ion containing physiological inorganic salt solutions, such as SBF or Hank's balanced salt solution (HBSS). 41,42 Shortly, the initial anodic corrosion reactions are the oxidations of Fe and Mn to ions, which are partially released in the electrolyte.…”

Section: Introductionmentioning

confidence: 99%

“…They were tested as potential material for bone, cardiovascular, and urinary applications. 30 , 37 , 39 , 40 …”

Section: Introductionmentioning

confidence: 99%

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Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Paul,

Kiel,

Otto

et al. 2024

ACS Appl. Bio Mater.

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Implant-related infections or inflammation are one of the main reasons for implant failure. Therefore, different concepts for prevention are needed, which strongly promote the development and validation of improved material designs. Besides modifying the implant surface by, for example, antibacterial coatings (also implying drugs) for deterring or eliminating harmful bacteria, it is a highly promising strategy to prevent such implant infections by antibacterial substrate materials. In this work, the inherent antibacterial behavior of the as-cast biodegradable Fe69Mn30C1 (FeMnC) alloy against Gram-negative Pseudomonas aeruginosa and Escherichia coli as well as Gram-positive Staphylococcus aureus is presented for the first time in comparison to the clinically applied, corrosion-resistant AISI 316L stainless steel. In the second step, 3.5 wt % Cu was added to the FeMnC reference alloy, and the microbial corrosion as well as the proliferation of the investigated bacterial strains is further strongly influenced. This leads for instance to enhanced antibacterial activity of the Cu-modified FeMnC-based alloy against the very aggressive, wild-type bacteria P. aeruginosa. For clarification of the bacterial test results, additional analyses were applied regarding the microstructure and elemental distribution as well as the initial corrosion behavior of the alloys. This was electrochemically investigated by a potentiodynamic polarization test. The initial degraded surface after immersion were analyzed by glow discharge optical emission spectrometry and transmission electron microscopy combined with energy-dispersive X-ray analysis, revealing an increase of degradation due to Cu alloying. Due to their antibacterial behavior, both investigated FeMnC-based alloys in this study are attractive as a temporary implant material.

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Remotely Controlled Electrochemical Degradation of Metallic Implants

Rivkin,

Akbar,

Otto

et al. 2024

Small

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Biodegradable medical implants promise to benefit patients by eliminating risks and discomfort associated with permanent implantation or surgical removal. The time until full resorption is largely determined by the implant's material composition, geometric design, and surface properties. Implants with a fixed residence time, however, cannot account for the needs of individual patients, thereby imposing limits on personalization. Here, an active Fe‐based implant system is reported whose biodegradation is controlled remotely and in situ. This is achieved by incorporating a galvanic cell within the implant. An external and wireless signal is used to activate the on‐board electronic circuit that controls the corrosion current between the implant body and an integrated counter electrode. This configuration leads to the accelerated degradation of the implant and allows to harvest electrochemical energy that is naturally released by corrosion. In this study, the electrochemical properties of the Fe‐30Mn‐1C/Pt galvanic cell model system is first investigated and high‐resolution X‐ray microcomputed tomography is used to evaluate the galvanic degradation of stent structures. Subsequently, a centimeter‐sized active implant prototype is assembled with conventional electronic components and the remotely controlled corrosion is tested in vitro. Furthermore, strategies toward the miniaturization and full biodegradability of this system are presented.

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Effect of Blasting Treatments on the Surface Topography and Cell Adhesion on Biodegradable FeMn‐Based Stents Processed by Laser Powder Bed Fusion

Abstract: The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adem.202200961.

Cited by 7 publications

References 66 publications

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Remotely Controlled Electrochemical Degradation of Metallic Implants

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