Effect of Bloodletting at Shaoshang and Shangyang Acupuncture Points on Outcome and Prognosis of Severe Community-Acquired Pneumonia in the Elderly

Fu, Yuefeng; Yang, Zhe; Cai, Yangping; Liu, Hongshuan; Li, Shuo; Kou, Nan; Wu, Jing Qin; Zhang, Qing

doi:10.1155/2021/3295021

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…A previous study demonstrated that needle bloodletting at LU 11 improved the symptoms of pneumonia. [51] Another study demonstrated that acupuncture at LU 11 blocked the infiltration of CD4 + T cells and inflammatory cells to regulate inflammation. [52] In addition, several studies have confirmed the local antinociceptive effect of acupuncture, thereby supporting local acupuncture in the throat.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture on acute pharynx infections: A systematic review and meta-analysis

et al. 2023

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Background: Several clinical reports have focused on acupuncture for the treatment of acute pharyngeal infections. However, the efficacy and safety of acupuncture for the treatment of acute pharyngeal infections are controversial. To systematically assess the efficacy and safety of acupuncture in treating acute pharynx infections, thus providing a reference for clinical decision-making.Methods: We searched PubMed, CENTRAL, Embase, Web of Science, China National Knowledge Infrastructure, China Biomedical, clinical research registration platforms, gray literature, and reference lists of the selected studies from inception to October 30, 2022. The risk of bias assessment was performed using RevMan. The meta-analysis was performed using STATA with the Hedges' g value. We also performed a subgroup analysis, meta-regression, and publication bias detection using Harbord's and Egger's tests.Results: We included 19 randomized controlled trials comprising 1701 patients, of which only one study had a high risk of bias. The primary outcome, i.e., the response rate, revealed that acupuncture was more effective than antibiotics. The secondary results revealed that the differences in the reduction of VAS scores, sore throat duration, and white blood cell counts were statistically significant in the acupuncture group compared with the antibiotic group. However, the difference in the modulation of the neutrophil percentage and C-reactive protein levels was insignificant. Moreover, the acupuncture treatment resulted in a lower incidence of adverse events than the antibiotic treatment.Conclusions: Thus, acupuncture therapy for acute pharyngeal infections is safe and its response rate is superior to that of antibiotics. Acupuncture showed positive outcomes for alleviating the sore throat symptoms, shortening the sore throat duration, and improving the immune inflammation index. Nevertheless, owing to the limitations of this study, our conclusions should be interpreted with caution. More high-quality trials are warranted in the future for improving the methodology and reporting quality.

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Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture on acute pharynx infections: A systematic review and meta-analysis

et al. 2023

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“…This study was designed as a superiority trial with a level of significance set at α=0.05, a type II error (β) of 0.2 and a power of the test of 80%. The sample size was calculated based on similar studies,7 with a 1:1 ratio between the intervention and control groups, and a dropout rate of 15% was considered. 66 patients with SP will be assigned to either intervention or control group and will undergo assessments on the 1st, 5th and 10th days of the treatment.…”

Section: Methodsmentioning

confidence: 99%

Dry cupping as an adjuvant treatment of individuals with severe pneumonia: study protocol for a placebo-controlled, randomised study

Li,

Chung,

Lei

et al. 2024

BMJ Open

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BackgroundSevere pneumonia (SP) stands as one of the most prevalent critical illnesses encountered in clinical practice, characterised by its rapid onset and progression, numerous complications and elevated mortality rates. While modern medical interventions primarily focus on symptomatic management such as anti-infective therapy and mechanical ventilation, challenges including high drug resistance and suboptimal therapeutic outcomes for certain patients persist. Dry cupping as an ancient practice with over a millennium of clinical use in China is renowned for its convenience and perceived clinical efficacy in various illnesses. Nevertheless, the lack of well-designed studies assessing its effects remains a notable gap in the literature. This protocol describes a placebo-controlled, randomised, single-blind study to evaluate the efficacy and safety of dry cupping as an adjuvant treatment for SP.Methods and analysis66 patients diagnosed with SP, aged 18–80 years, will be randomly divided into two groups: intervention group, receiving 10 times of dry cupping treatment; control group, receiving placebo dry cupping therapy. Both applications are used in bilateral Fei Shu (BL13), Pi Shu (BL21) and Shen Shu (BL22) cupping. The application will be conducted once a day for 10 days. Participants will be assessed before treatment (D0), after the first intervention (D1), after the fifth intervention (D5) and after treatment ended (D10). The assessments include blood oxygen saturation, respiratory rate, traditional Chinese medicine symptom score, inflammatory response, mechanical ventilation time and oxygen condition.Ethics and disseminationThis protocol has been approved by the Ethics Committee of Shanghai Seventh People’s Hospital (2023-7th-HIBR-070). The results of the study will be disseminated to participants through social networks and will be submitted to a peer-reviewed journal and scientific meetings.Trial registration numberChiCTR2300076958.

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“…Infections caused by pathogenic bacteria are threatening human beings' health worldwide [1]. These bacteria are easily to develop drug resistance during antibiotics treatment processes [2]. Once obtained resistance, bacteria are often difficult to eradicate by antibiotics [3].…”

Section: Introductionmentioning

confidence: 99%

Integrated multi-omics analysis ofKlebsiella pneumoniaerevealed the discrepancy in flavonoid effect against strain growth between Rutin and Luteolin

Wang,

Shen,

et al. 2024

Preprint

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The emergence of drug resistant pathogenic bacteria is increasingly challenging conventional antibiotics. Plant derived flavonoids are always considered as potential alternatives to antibiotics due to their antimicrobial properties. However, the molecular mechanisms by which flavonoids inhibit pathogenic microorganisms’ growth are not fully understood. In order to better understand the inhibitory mechanism of flavonoids, two flavonoids were used to incubateKlebsiella pneumoniaeATCC700603. After incubation for 4 hours, both the metabolomic and transcriptomic analysis were performed. In present study, 5,483 genes and 882 metabolites were measured. Compared to wild control, the Rutin and Luteolin induced 507 and 374 differentially expressed genes (DEGs), respectively. However, the number of differential abundant metabolites (DAMs) were the same. The correlation between DEGs and DAMs were studied. The top 10 correlated DEGs and DAMs were identified in each comparative groups. Our results showed that, compared to Luteolin, Rutin induced the accumulation of metabolites and suppressed genes’ expression. Our results provided an explanation for the disparate effects of two flavonoids and demonstrated the inhibitory mechanism of Rutin on strain growth.

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Effect of Bloodletting at Shaoshang and Shangyang Acupuncture Points on Outcome and Prognosis of Severe Community-Acquired Pneumonia in the Elderly

Cited by 7 publications

References 2 publications

Efficacy of acupuncture on acute pharynx infections: A systematic review and meta-analysis

Efficacy of acupuncture on acute pharynx infections: A systematic review and meta-analysis

Dry cupping as an adjuvant treatment of individuals with severe pneumonia: study protocol for a placebo-controlled, randomised study

Integrated multi-omics analysis ofKlebsiella pneumoniaerevealed the discrepancy in flavonoid effect against strain growth between Rutin and Luteolin

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