2018
DOI: 10.1002/mrd.23096
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Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows

Abstract: The high metabolic activity to which the dairy cattle are exposed to maintain milk production altered steroid metabolism that affects reproductive physiology and reduce oocyte competence. Our aims were (a) to characterize the competence of immature oocytes collected from dairy cattle based on the expression of genes in cumulus cells (CCs) and (b) to improve oocyte competence to support preimplantation embryo development by the supplementation of maturation medium with bone morphogenetic protein 15 (BMP15) and/… Show more

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Cited by 9 publications
(9 citation statements)
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“…Nevertheless, the impact of AMH on oocyte competence is still ambiguous. Based on the results of the in vitro maturation (IVM) studies on animals, AMH may improve oocyte competence via up-regulating the expression of the Bone Morphogenetic Protein-15 (BMP-15) and the Growth Differentiation Factor-9 (GDF-9) in mice [55], but not in cows [56]. A recent study on human germinal vesicle oocytes (GV) showed that adding recombinant AMH to the IVM medium improved the maturation rate.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, the impact of AMH on oocyte competence is still ambiguous. Based on the results of the in vitro maturation (IVM) studies on animals, AMH may improve oocyte competence via up-regulating the expression of the Bone Morphogenetic Protein-15 (BMP-15) and the Growth Differentiation Factor-9 (GDF-9) in mice [55], but not in cows [56]. A recent study on human germinal vesicle oocytes (GV) showed that adding recombinant AMH to the IVM medium improved the maturation rate.…”
Section: Discussionmentioning
confidence: 99%
“…BMP15 is an important cytokine that is expressed specifically in the ovaries of mammals [3]. As an oocyte-secreted growth factor, BMP15 plays paracrine/autocrine roles in regulating the functions of GCs (e.g., proliferation, differentiation, and apoptosis) and in stimulating the action of follicle-stimulating hormone (FSH), the expansion of cumulus cells, and ovulation [36,37,38]. Importantly, BMP15 has been shown to be essential for female fertility in most mammalian species; in particular, homozygosity for BMP15 mutations leads to subfertility in mice and sterility in sheep [39,40].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, Hussein et al (2005) demonstrated an anti-apoptotic effect of BMP15 in in vitro-cultured bovine CC and BMP15 added to in vitro maturation medium increased the percentage of CC expansion (Alam & Miyano, 2019;Caixeta, Sutton-Mcdowall, et al, 2013). Besides early effects on oocytes and CCs, the use of BMP15 during in vitro maturation modulated the expression of genes involved in embryo development such as OCT4, SOX2, CDX2, GATA6 and TP1 in blastocysts (Velásquez et al, 2019). Gupta et al (2017) suggested that BMP15 and GDF9 supplementation during IVM modulates the developmental competence of buffalo oocytes by increasing cleavage rate and blastocyst quality.…”
mentioning
confidence: 94%
“…(2005) demonstrated an anti‐apoptotic effect of BMP15 in in vitro‐cultured bovine CC and BMP15 added to in vitro maturation medium increased the percentage of CC expansion (Alam & Miyano, 2019; Caixeta, et al., 2013; Caixeta, Sutton‐Mcdowall, et al., 2013). Besides early effects on oocytes and CCs, the use of BMP15 during in vitro maturation modulated the expression of genes involved in embryo development such as OCT4, SOX2, CDX2, GATA6 and TP1 in blastocysts (Velásquez et al., 2019). Gupta et al.…”
Section: Introductionmentioning
confidence: 99%