Effect of body mass index on bone mineral density is age-specific

Cherukuri, Lavanya; Kinninger, April; Birudaraju, Divya; Lakshmanan, Suvasini; Li, Dong; Flores, Ferdinand; Mao, Song; Budoff, Matthew J.

doi:10.1016/j.numecd.2021.02.027

Cited by 27 publications

(21 citation statements)

References 56 publications

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“…Currently, clinical researches regarding the correlation between obesity and BMD were limited and controversial. A study from US reported a signi cant positive association between the obesity and BMD existed in elder groups in both genders [9]. In a study of 502 northern Chinese men identi ed that, total body and regional BMD of obesity were signi cantly higher compared to normal weight (P < 0.001) [10].…”

Section: Discussionmentioning

confidence: 98%

Association Between Obesity and Bone Mineral Density in Middle-Aged Adults

2022

Preprint

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Background The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (Body mass index ≥ 30) and BMD among adults 40-59 years of age. Methods This study was conducted on a sample of 2218 participants (986 men and 1232 women) aged from 40 to 59 years, from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. The independent variable was Body mass index (BMI) and the dependent variable was lumbar BMD. We performed weighted multivariate linear regression models and smooth curve fittings to evaluate the associations between BMI and lumbar BMD. Results The BMI was positively associated with lumbar BMD, after adjusting for other covariates (β 0.006; 95% confidence interval (CI) 0.003-0.008). An inverted U-shaped association between the BMI and lumbar BMD was further identified, with the point of infection was at about 50 kg/m2. On subgroup analyses, the relationship between BMI and lumbar BMD of women and blacks were inverted U-shaped. Conclusion Based on the result, it may be beneficial to appropriately increase BMI to promote BMD. However, considering the inverted U-shaped association, an excessive BMI may be harmful to bone health on women and blacks.

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Section: Discussionmentioning

confidence: 98%

Association Between Obesity and Bone Mineral Density in Middle-Aged Adults

2022

Preprint

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“…Currently, clinical studies regarding the correlation between obesity and BMD are limited and controversial. A study from the US reported a significant positive association between obesity and BMD existed in elderly groups of both sexes [ 9 ]. In a study of 502 northern Chinese men, the total body and regional BMD in obese subjects were significantly higher than those of subjects with normal weight ( P < 0.001) [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Association between obesity and bone mineral density in middle-aged adults

2022

J Orthop Surg Res

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Background The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (body mass index ≥ 30) and BMD among adults 40–59 years of age. Methods This study was conducted on a sample of 2218 participants (986 men and 1232 women) aged 40 to 59 years from the National Health and Nutrition Examination Survey 2011–2018. The independent variable was body mass index (BMI). The outcome variable was lumbar BMD. The associations of BMI with lumbar BMD were examined using multivariable linear regression models. Results BMI was positively associated with lumbar BMD after adjusting for other covariates [β 0.006; 95% confidence interval (CI) 0.003–0.008]. An inverted U-shaped association between BMI and lumbar BMD was further identified, with the point of infection at approximately 50 kg/m2. In the subgroup analyses, the relationship between BMI and lumbar BMD in women and blacks was an inverted U-shape. Conclusion Based on the results, it may be beneficial to appropriately increase BMI to promote BMD. However, considering the inverted U-shaped association, excessive BMI may be harmful to bone health in women and blacks.

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“…The previous study has identified variants in ESR1 and close proximity to RANKL showed a clear effect dependency on age for BMD [ 19 ]. According to recent studies, glucose homeostasis and anthropometric traits are associated with site-specific BMD and body mass index with age-specific BMD [ 46 , 47 ]. Meanwhile, it has been reported that epigenetic modifications are highly dynamic, age-, and tissue-specific, and sensitive to endogenous signals and/or environmental stimulation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

A genetic correlation scan identifies blood proteins associated with bone mineral density

Zhang

et al. 2022

BMC Musculoskelet Disord

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Background Osteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore the functional relevance of the blood proteome to bone mineral density across different life stages. Methods Using genome-wide association study summary data of the blood proteome and two independent studies of bone mineral density, we conducted a genetic correlation scan of bone mineral density and the blood proteome. Linkage disequilibrium score regression analysis was conducted to assess genetic correlations between each of the 3283 plasma proteins and bone mineral density. Results Linkage disequilibrium score regression identified 18 plasma proteins showing genetic correlation signals with bone mineral density in the TB-BMD cohort, such as MYOM2 (coefficient = 0.3755, P value = 0.0328) among subjects aged 0 ~ 15, POSTN (coefficient = − 0.5694, P value = 0.0192) among subjects aged 30 ~ 45 and PARK7 (coefficient = − 0.3613, P value = 0.0052) among subjects aged over 60. Conclusions Our results identified multiple plasma proteins associated with bone mineral density and provided novel clues for revealing the functional relevance of plasma proteins to bone mineral density.

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Effect of body mass index on bone mineral density is age-specific

Cited by 27 publications

References 56 publications

Association Between Obesity and Bone Mineral Density in Middle-Aged Adults

Association Between Obesity and Bone Mineral Density in Middle-Aged Adults

Association between obesity and bone mineral density in middle-aged adults

A genetic correlation scan identifies blood proteins associated with bone mineral density

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