DefinitionsGas embolism refers to the abnormal presence of gas within the circulatory system. It is a known complication of various surgical, therapeutic, and diagnostic procedures. It can also occur as a result of trauma. Gas embolism may be asymptomatic or may even result in immediate cardiovascular collapse. The type and severity of sequelae depend on the composition and amount of gas, the rate and location of entry, and on patient characteristics such as size, cardiopulmonary reserve, and presence of an intracardiac rightleft communication. An understanding of the etiologies and pathophysiology of gas embolism is important in order to recognize, treat, and, most importantly, prevent this potentially catastrophic complication.Gas enters the circulation when two conditions co-exist: (1) a communication between a gas source and the vascular system, and (2) a pressure gradient that favors gas entry into the vasculature. When the atmosphere is the source of gas, then this condition is termed air embolism. Gas can be entrained into open veins or venous sinuses, insufflated into traumatized vessels, or accidentally infused under pressure through indwelling venous or arterial catheters. Rarely, dissolved gas is released in blood through effervescence caused by rapid re-warming or decompression. 1 Venous (pulmonary) gas embolism (VGE) refers to gas that gains entry into the venous system and causes morbidity via its effects on the right heart and pulmonary vasculature. Systemic (arterial) gas embolism (SGE) results from gas that is propelled by the left heart and embolizes to systemic arterial beds causing ischemia and infarction. Paradoxical gas embolism (PGE) originates in the venous system and gains access to the arterial system through intracardiac defects or the pulmonary circulation.