Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity

Pomeroy, Claire; Mitchell, James E.; Eckert, Elke D.; Raymond, Nancy C.; Crosby, Ross D.; Dalmasso, A. P.

doi:10.1046/j.1365-2249.1997.3921287.x

Cited by 93 publications

(82 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cross-sectional studies have shown that obesity is associated with elevated plasma levels of C3 [4,[6][7][8][9][10], but the causal and temporal relations of this association have been unclear. The present study showed that C3 was strongly associated both with weight at baseline and weight at follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Complete birth cohorts from the city of Malmö were invited [17] and the participation rate was 71%. Plasma protein determination was part of the programme for 6,193 men who were selected at random from cohorts examined between 1974 and 1982. After the exclusion of men with diabetes or a history of myocardial infarction, stroke or cancer (according to questionnaire), 5,729 men remained.…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

“…Individuals who are overweight or obese generally have raised concentrations of C3 and C4 [4][5][6][7][8][9][10], and it has been reported that C3 levels decrease after weight loss [6,7]. The proteolytic fragment of C3, acylation-stimulating protein (ASP), is a paracrine metabolic factor that stimulates the uptake of glucose and fat storage in human adipose tissue [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study

et al. 2005

View full text Add to dashboard Cite

Aims/hypothesis: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods: Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. Results: After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, ≥3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7-1.2), 1.1 (CI:0.9-1.5) and 1.4 (CI: 1.1-1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend= 0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, α1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. Conclusions/interpretation: C3 is a risk factor for incurring large weight gain in middleaged men.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Subjects Materials and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In mice, restriction of energy intake increased serum adipsin levels (Spurlock et al, 1996). Body weight changes correlate with changes in serum levels of complement proteins (Pomeroy et al, 1997) in humans as well. Interestingly, the present data suggested that a greater increase in abdominal subcutaneous fat induced by overfeeding was related to a lower increase in plasma adipsin level.…”

Section: Discussionmentioning

confidence: 92%

Genetic variation at the adipsin locus and response to long-term overfeeding

et al. 2003

View full text Add to dashboard Cite

Objectives: The role of adipsin and adipsin Hinc II polymorphisms on the metabolic and body composition changes in response to overfeeding was studied. Subjects: A total of 12 pairs of male monozygotic twins ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. Results: The preoverfeeding plasma adipsin concentration correlated positively with the change in CT-measured abdominal total and subcutaneous (Po0.05) fat. The changes in abdominal total fat and abdominal subcutaneous fat correlated negatively with changes in plasma adipsin concentrations (Po0.005). Overfeeding induced greater increases in body weight, fat mass, abdominal total and subcutaneous fat (Po0.05) in 6.1 kb noncarriers (n ¼ 10) than in 6.1 kb carriers (n ¼ 14) of the adipsin Hinc II polymorphism. The 6.1 kb noncarriers had a greater increase in plasma leptin levels (Po0.01). Also the total (Po0.01) and very-low-density lipoprotein (VLDL)-triglycerides (Po0.05), apolipoprotein B (Po0.05) and VLDL-cholesterol (Po0.05) levels increased more in the 6.1 kb noncarriers than in the 6.1 kb carriers. Conclusions: Adipsin plasma level could be a predictor of the changes in abdominal subcutaneous fat during times of increased energy intake. However, a greater increase in the abdominal subcutaneous fat was related to a lower increase in the plasma adipsin level. The adipsin Hinc II 6.1 kb allele noncarriers gained more abdominal subcutaneous fat and had a greater increase in plasma levels of leptin-and triglyceride-rich lipoproteins when exposed to a long-term positive energy balance. These findings provide new information on the role of adipsin on individual differences in response to chronically elevated food intake.

show abstract

“…65 C3 and Factor B are positively correlated with body weight and visceral fat, and decrease after weight loss 66,67 ASP secretion by the adipose tissue is increased after meals and stimulates TG synthesis and decreases nonesterified FA release in adipocytes. 65 Levels of plasma ASP have been positively correlated with obesity, percent body fat and with insulin resistance.…”

Section: Inflammatory Proteins and Cytokinesmentioning

confidence: 97%

The entero-insular axis and adipose tissue-related factors in the prediction of weight gain in humans

2006

Int J Obes

View full text Add to dashboard Cite

Obesity has now reached epidemic proportions. Epidemiological studies in the past decades have shown that adults gain weight and adiposity from the early twenties until their sixties. In the paediatric population, growing numbers of children and adolescents put on unhealthy weight. Many environmental, socio-economical and biological determinants that predispose to weight gain have been identified thus far. The aim of the present review is to summarize the current knowledge on the role of the circulating levels of adipokines and other entero-insular hormones and biological markers of obesity to predict weight gain in humans. The review focuses on relationship between hormonal and biochemical markers (insulin, insulin-like growth factors, gastrointestinal hormones, leptin, adiponectin, resistin, inflammatory proteins and cytokines) and weight gain in prospective studies. The complex relationships displayed by these hormonal factors with future weight gain in humans are critically reviewed and integrative models are proposed. Overall, most of the studies reported to date made adjustments for baseline body mass index but failed to consider dietary intake and physical activity as confounding factors. Outstanding questions are raised and new directions for future prospective studies are proposed in order to improve our understanding of the role of biological determinants of energy balance and development of obesity in humans.

show abstract

Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity

Cited by 93 publications

References 20 publications

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study

Genetic variation at the adipsin locus and response to long-term overfeeding

The entero-insular axis and adipose tissue-related factors in the prediction of weight gain in humans

Contact Info

Product

Resources

About