Copolymerization reactions of 3-glycidyloxypropyltrimethoxysilane (GPTS) with L-lactide (LLA) at 100°C for different time intervals are performed by various catalysts such as zirconium perfluoroheptanoate, and commercially available Tin(II) chloride (SnCl 2 ) and sodium trimethylsilanolate (NaOSiMe 3 ). Homo-and copolymers are characterized by FTIR, 1 H-and 13 C-NMR spectroscopies, electrospray ionization mass spectroscopy, thermal gravimetric analysis, differential scanning calorimetry and gel permeation chromatography. All selected catalysts are effective in ROP of monomers. Especially, SnCl 2 is more reactive catalyst in the copolymerization of LLA/GPTS. The structure of final product is found as random copolymers.