Effect of bombesin at low doses on the secretion of the exocrine pancreas and on plasma gastrin concentration in the conscious pig

Lhoste, Évelyne; Levenez, Florence; Chabanet, Claire; Fiszlewicz, Michèle; Corring, T.

doi:10.1016/s0167-0115(98)00014-7

Cited by 4 publications

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“…The pancreatic acinar cells themselves, however, exhibit specific bombesin receptors (Jensen et al 1978;Jensen & Gardner, 1984). Indeed, in studies on isolated perfused pig pancreas (Knuhtsen et al 1985) and conscious growing pigs (Lilja et al 1984;Lhoste et al 1998), it was observed that the administration of bombesin-like peptides stimulates exocrine pancreatic secretion.…”

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The Role of Cholinergic and Peptidergic Pathways in the Regulation of Pancreatic Exocrine Function During Postnatal Development in Pigs

Leśniewska

Gregard

Weström

et al. 2001

Experimental Physiology

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The aim of this study was to investigate the role of the parasympathetic (cholinergic and peptidergic) nervous system in the regulation of exocrine pancreas function in piglets during their early postnatal development. The cholinergic and peptidergic regulatory pathways of exocrine pancreatic function were tested by the specific muscarinic receptor blocker 4-diphenylacetoxy-N-methylpiperidine-methiodide (4-DAMP) and bombesin, respectively. At the age of 2 weeks, piglets were surgically fitted with a chronic pancreatic duct catheter, a duodenal re-entrant cannula and a jugular vein catheter. The experiments comprised a pre-weaning period, and a post-weaning period that commenced at the beginning of the 5th week of age. Intravenous infusion of 4-DAMP (100 pmol kg _1 h _1 ) reduced the outflow of pancreatic juice, the output of total protein and the activity of trypsin, chymotrypsin, carboxyl ester hydrolase and amylase during preprandial and postprandial pancreatic secretion, in both the pre-and post-weaning periods. However, the inhibitory effect of 4-DAMP during postprandial secretion was significantly greater (P < 0.05) in suckling piglets. The infusion of bombesin (10, 100 and 1000 pmol kg _1 h _1) stimulated exocrine pancreatic secretion in a dose-dependent manner during both the pre-and post-weaning periods. However, the stimulatory effect of 1000 pmol kg _1 h _1 bombesin on total protein output and the activities of trypsin, chymotrypsin and amylase were significantly higher (P < 0.05) in suckling piglets. In summary, our study showed that cholinergic and peptidergic mechanisms are involved in the regulation of exocrine pancreas function in piglets in both the pre-and post-weaning stages. 4-DAMP had a greater inhibitory effect on exocrine pancreatic secretion in piglets during the pre-weaning period. Thus, these observations suggest that the parasympathetic nervous system plays a dominant role in the functioning of the exocrine pancreas at this time. The action of bombesin suggests that it is a potent secretagogue for the exocrine pancreas in pigs during their postnatal development. Experimental Physiology (2001) 86.3, 399-409. 2151

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confidence: 99%

The Role of Cholinergic and Peptidergic Pathways in the Regulation of Pancreatic Exocrine Function During Postnatal Development in Pigs

Leśniewska

Gregard

Weström

et al. 2001

Experimental Physiology

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“…The effects of bombesin on pancreatic exocrine secretion appear to vary based on the species. In pigs, administration of bombesin alone or in combination with secretin induced protein but not fluid secretion (185). In guinea pigs, bombesin was very effective in inducing bicarbonate release from interlobular ducts, and this effect was blocked by a GRP receptor antagonist (318).…”

Section: Bombesinmentioning

confidence: 96%

Regulation of Pancreatic Secretion

Liddle

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Bombesin-like peptides stimulate growth hormone secretion mediated by the gastrin-releasing peptide receptor in cattle

et al. 2012

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Effect of bombesin at low doses on the secretion of the exocrine pancreas and on plasma gastrin concentration in the conscious pig

Cited by 4 publications

References 25 publications

The Role of Cholinergic and Peptidergic Pathways in the Regulation of Pancreatic Exocrine Function During Postnatal Development in Pigs

The Role of Cholinergic and Peptidergic Pathways in the Regulation of Pancreatic Exocrine Function During Postnatal Development in Pigs

Regulation of Pancreatic Secretion

Bombesin-like peptides stimulate growth hormone secretion mediated by the gastrin-releasing peptide receptor in cattle

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