Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Yuan, Shufang; Jiang, Tao; Zheng, Rongjiong; Sun, Lihua; Cao, Guiqiu; Zhang, Yuexin

doi:10.3892/etm.2014.1848

Cited by 15 publications

(6 citation statements)

References 33 publications

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“…Transplantation of different origin MSCs rescued acute liver failure and repopulated mouse liver through paracrine effects that reduced the inflammatory response, inhibited apoptosis in the liver, and stimulated endogenous regeneration mechanisms [96]. …”

Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

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Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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“…4 It has been examined and confirmed in a previous study that pathological features of liver failure could be alleviated through BMSC transplantation. 7 However, the molecular mechanism involved in BMSCs transplantation remains highly unknown in ALF treatment.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of microRNA‐214 improves therapeutic potential of allogeneic bone marrow–derived mesenchymal stem cell by targeting PIM‐1 in rats with acute liver failure

Yang

Zhao

et al. 2019

J of Cellular Biochemistry

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Acute liver failure (ALF) is a disease resulted from diverse etiology, which generally leads to a rapid degenerated hepatic function. However, transplantation bone marrow-derived mesenchymal stem cells (BMSCs) transplantation has been suggested to relieve ALF. Interestingly, could potentially regulate differentiation and migration of BMSCs. The present study aims to inquire whether miR-214 affects therapeutic potential of BMSCs transplantation by targeting PIM-1 in ALF. 120 male Wistar rats were induced as ALF model rats and transplanted with BMSCs post-alteration of miR-214 or PIM-1 expression. Further experiments were performed to detect biochemical index (alanine aminotransferase [ALT], aspartate transaminase [AST], total bilirubin [TBiL]), and expression of miR-214, PIM-1, hepatocyte growth factor (HGF), caspase 3, tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) in rat serum. Apart from the above detection, apoptosis of hepatocytes and Ki67 protein expression in hepatic tissues of rats were additionally assessed. After BMSCs transplantation with miR-214 inhibition, a decreased expression of ALT, AST, and TBiL yet an increased expression of HGF was shown, coupled with a decline in the expression of caspase 3, TNF-α, and IL-10. Meanwhile, alleviated hepatic injury and decreased apoptotic index of hepatic cells were observed and the positive rate of Ki67 protein expression was significantly increased.Moreover, miR-214 and caspase 3, TNF-α, and IL-10 decreased notably, while PIM-1 was upregulated in response to miR-214 inhibition. Strikingly, the

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“…Кроме того, применение клеточных технологий способствовало снижению активности печеночных ферментов. Большинство авторов подтверждают подобный эффект при использовании клеточной терапии [18,19]. Однако есть значимая разница между скоростью и степенью снижения активности печеночных ферментов, что, вероятно, связано с использованием разных моделей формирования диффузных заболеваний печени [18,20,21].…”

Section: Discussionunclassified

The effect of stem cells on the functional state of liver tissue against the background of a liver cirrhosis model (experimental study)

Kotkas

Мазуров

2021

HERALD of North-Western State Medical University named after I.

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Relevance. Treatment of liver cirrhosis is an extremely important problem of modern medicine. Improvement of liver function in this category of patients is important not only for hepatology, but also for surgery, since surgical interventions on the liver in this pathology are often accompanied by the development of liver failure. Purpose. To evaluate the effect of cell therapy on liver function in the experiment. Materials and methods. The article presents the results of the experimental use of use of stem cells in simulated liver cirrhosis. The experiment was performed on 132 female c57black mice, which were between 12 and 18 weeks old. After forming a model of liver cirrhosis, in order to assess the effect of cell therapy on the function of liver tissue, individuals were injected with stem cells through the vessels of the peripheral bed and intraportally. 30 days after cell therapy, the blood levels of ALT, AST, alkaline phosphatase, plasma diene conjugants, plasma malondialdehyde, plasma superoxide dismutase, and glutathione peroxidase were evaluated. Conclusion. According to the findings, obtained in the experiment, the use of cell therapy against the background of simulated cirrhosis of the liver contributed to a decrease in the severity of cytolytic and cholestatic syndromes, stimulation of liver protein function, suppression of free radical oxidation and stimulation of the antioxidant system. At the same time, the best effect was achieved when the cell structures were introduced not into the peripheral vessels, but directly into the vascular bed of the liver.

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Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Cited by 15 publications

References 33 publications

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Downregulation of microRNA‐214 improves therapeutic potential of allogeneic bone marrow–derived mesenchymal stem cell by targeting PIM‐1 in rats with acute liver failure

The effect of stem cells on the functional state of liver tissue against the background of a liver cirrhosis model (experimental study)

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