Effect of bone meal on growth traits, photosynthetic pigment content, and essential oil chemical composition of Pelargonium graveolens

Atemni, Ibrahim; Touijer, Hanane; Hjouji, Kaoutar; Tlemcani, Sara; Ainane, Tarik; Taleb, M.; Raïs, Z.

doi:10.1016/j.indcrop.2023.117021

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…According to previous studies [4,5,18,19], the phytochemical profile of R. damascena essential oil was found to be similar to the results obtained in the present work. Likewise, P. graveolens essential oil contained abundant amounts of geraniol and citronellol as also reported in previous work [20].…”

Section: Phytochemical Analysissupporting

confidence: 87%

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of Rosa x damascena and Pelargonium graveolens Essential Oils and Geraniol

Karadağ,

Biltekin,

Demirci

et al. 2023

Plants

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The present work aims to evaluate Rosa x damascena Herrm. and Pelargonium graveolens L’Hér. essential oils, and the major constituent geraniol for their in vitro and in silico inhibitory activities against 5-lipoxygenase (5-LOX), cyclooxygenase (COX), acetyl cholinesterase (AChE), butyryl cholinesterase (BuChE), and angiotensin converting enzyme (ACE2) enzymes. Geraniol most potently inhibited the ACE2 relative to other enzymes. R. damascena essential oil moderately inhibited the cancer cell lines with no toxic effects on healthy HEK 293 cells. P. graveolens essential oil inhibited a number of cancer cell lines including A549, MCF7, PC3, and HEK 293 that are reported here for the first time. The molecular docking of geraniol with the target enzymes revealed that it binds to the active sites similar to that of known drugs. Geraniol carries the potential for further drug development due to its drug-like binding mode for the target enzymes. Our work confirms that these essential oils possess similar biological activities due to their similar phytochemistry in terms of the major constituents of the plants. The promising biological activities reported in this work further warrant the inclusion of in vivo studies to establish safe use of the target essential oils and their constituents.

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Section: Phytochemical Analysissupporting

confidence: 87%

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of Rosa x damascena and Pelargonium graveolens Essential Oils and Geraniol

Karadağ,

Biltekin,

Demirci

et al. 2023

Plants

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“…Depending on the pathway followed, the constituents of essential oils predominantly belong to two distinct biosynthetic families: terpenoids and phenylpropanoids. Monoterpenes (consisting of 10 carbons) and sesquiterpenes (consisting of 15 carbons) are the most commonly found compounds in EOs, although diterpene constituents may also be present [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Mohamed Abdoul-Latif,

Ainane,

Houmed Aboubaker

et al. 2023

Pharmaceuticals

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Cancer is one of the leading causes of death worldwide, affecting millions of people each year. Fortunately, the last decades have been marked by considerable advances in the field of cancer therapy. Researchers have discovered many natural substances, some of which are isolated from plants that have promising anti-tumor activity. Among these, essential oils (EOs) and their constituents have been widely studied and shown potent anticancer activities, both in vitro and in vivo. However, despite the promising results, the precise mechanisms of action of EOs and their bioactive compounds are still poorly understood. Further research is needed to better understand these mechanisms, as well as their effectiveness and safety in use. Furthermore, the use of EOs as anticancer drugs is complex, as it requires absolute pharmacodynamic specificity and selectivity, as well as an appropriate formulation for effective administration. In this study, we present a synthesis of recent work on the mechanisms of anticancer action of EOs and their bioactive compounds, examining the results of various in vitro and in vivo studies. We also review future research prospects in this exciting field, as well as potential implications for the development of new cancer drugs.

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Effect of Bone Meal Application on Soil Properties, Heavy Metal Accumulation, and Agronomic Traits of Pelargonium graveolens

Atemni,

Hjouji,

Barnossi

et al. 2023

J Soil Sci Plant Nutr

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Effect of bone meal on growth traits, photosynthetic pigment content, and essential oil chemical composition of Pelargonium graveolens

Cited by 3 publications

References 43 publications

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of Rosa x damascena and Pelargonium graveolens Essential Oils and Geraniol

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of Rosa x damascena and Pelargonium graveolens Essential Oils and Geraniol

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Effect of Bone Meal Application on Soil Properties, Heavy Metal Accumulation, and Agronomic Traits of Pelargonium graveolens

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