Effect of Bovine Lactoferrin on Functions of Activated Feline Peripheral Blood Mononuclear Cells During Chronic Feline Immunodeficiency Virus Infection

Kobayashi, Saori; Sato, Ryo; Aoki, Takako; Omoe, Katsuhiko; Inanami, Osamu; Hankanga, Careen; Yamada, Yuichi; Tomizawa, Nobuyuki; Yasuda, Jun; Sasaki, Juso

doi:10.1292/jvms.70.429

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…4). This finding is consistent with published studies demonstrating that Lac suppressed mitogen Con A or phytohaemagglutinininduced cell proliferation and expression of IFN-g by peripheral blood mononuclear cells and splenocytes in vitro (32,33).…”

Section: Viral and Autoimmune Hepatitis As Well As Other Types Of Immsupporting

confidence: 93%

Lactoferrin protects against concanavalin A-induced liver injury in mice

Yin

Cheng

Agarwal

et al. 2010

Liver International

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Section: Viral and Autoimmune Hepatitis As Well As Other Types Of Immsupporting

confidence: 93%

Lactoferrin protects against concanavalin A-induced liver injury in mice

Yin

Cheng

Agarwal

et al. 2010

Liver International

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“…The addition of 500 µg/ml bLf after ConA significantly inhibited the expression of IFN-γ and IL-2 in FIV-positive cats. This study suggested that treatment with bLf could maintain the immune homeostasis of immunosuppressed FIV-positive cats [76].…”

Section: In Vivo Assaysmentioning

confidence: 70%

Lactoferrin: A Powerful Antimicrobial Protein Present in Milk

Luna-Castro¹,

Samaniego-Barrón²,

Serrano-Rubio³

et al. 2017

J Adv Dairy Res

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Lactoferrin (Lf) is an iron-chelating glycoprotein present in milk and mucosal secretions, a component of the mammalian innate immune system. Lf is microbiostatic and microbicidal. Lf can reduce the bacterial expression of virulence factors, such as those involved in biofilm production and protease secretion. The high identity among mammalian Lf sequences facilitates its use in human and veterinary medicine. Lf of bovine origin is the principal Lf used due to its commercial availability through purification from milk whey; recombinant Lfs (bovine, human, and porcine) have been used as well. Lf is a stable protein that retains its physicochemical characteristics under gastric pH conditions, and in most cases it is bioactive even after digestion; thus, the incorporation of Lf into diets facilitates its administration to animals. The aim of this review is to examine original research in which the effects of bovine and porcine Lf on pathogens of domestic animals have been demonstrated through in vitro and in vivo assays, with the purpose of ascertaining the benefits that Lf provides in the treatment of infectious diseases.

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“…It has been reported that oral administration of bLf suppressed oral inflammation in feline immunodeficiency virus FIV-infected cats with intractable stomatitis infection. This result suggests that bLf therapy may have a potential application to improve and protect functions of overactivated lymphocytes by modulating the cell proliferation, cell cycle and cytokines expression as shown in cats in terminal stage of FIV infection [ 88 ].…”

Section: Inhibition Of Viral Infections By Lactoferrinmentioning

confidence: 99%

Antiviral Properties of Lactoferrin—A Natural Immunity Molecule

et al. 2011

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Lactoferrin, a multifunctional iron binding glycoprotein, plays an important role in immune regulation and defence mechanisms against bacteria, fungi and viruses. Lactoferrin’s iron withholding ability is related to inhibition of microbial growth as well as to modulation of motility, aggregation and biofilm formation of pathogenic bacteria. Independently of iron binding capability, lactoferrin interacts with microbial, viral and cell surfaces thus inhibiting microbial and viral adhesion and entry into host cells. Lactoferrin can be considered not only a primary defense factor against mucosal infections, but also a polyvalent regulator which interacts in viral infectious processes. Its antiviral activity, demonstrated against both enveloped and naked viruses, lies in the early phase of infection, thus preventing entry of virus in the host cell. This activity is exerted by binding to heparan sulphate glycosaminoglycan cell receptors, or viral particles or both. Despite the antiviral effect of lactoferrin, widely demonstrated in vitro studies, few clinical trials have been carried out and the related mechanism of action is still under debate. The nuclear localization of lactoferrin in different epithelial human cells suggests that lactoferrin exerts its antiviral effect not only in the early phase of surface interaction virus-cell, but also intracellularly. The capability of lactoferrin to exert a potent antiviral activity, through its binding to host cells and/or viral particles, and its nuclear localization strengthens the idea that lactoferrin is an important brick in the mucosal wall, effective against viral attacks and it could be usefully applied as novel strategy for treatment of viral infections.

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Effect of Bovine Lactoferrin on Functions of Activated Feline Peripheral Blood Mononuclear Cells During Chronic Feline Immunodeficiency Virus Infection

Cited by 13 publications

References 34 publications

Lactoferrin protects against concanavalin A-induced liver injury in mice

Lactoferrin protects against concanavalin A-induced liver injury in mice

Lactoferrin: A Powerful Antimicrobial Protein Present in Milk

Antiviral Properties of Lactoferrin—A Natural Immunity Molecule

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