Effect of Brimonidine on Retinal Vascular Autoregulation and Short-term Visual Function in Normal Tension Glaucoma

Abstract

Brimonidine significantly improved impaired retinal vascular autoregulation in normal tension glaucoma patients, but short-term alteration in visual function could not be demonstrated.

Increased risk of open‐angle glaucoma among patients with diabetes mellitus: a 10‐year follow‐up nationwide cohort study

“…; Feke et al. ). In addition, increased retinal susceptibility to glaucomatous damage with diabetes‐related vascular changes may also explain the association (Kanamori et al.…”

Autoregulation of optic nerve head blood flow and its role in open-angle glaucoma

“…Although both groups had similar flow values at baseline, the glaucomatous cohort showed a broad and significant range of hemodynamic responses while lying flat compared with sitting (p = 0.0025), indicating vascular dysregulation. Subsequent work by the same group evaluated the effect of glaucoma medications on retinal autoregulation using the same methodology and found that brimonidine significantly improves retinal vascular autoregulation in NTG patients [150,151] and that switching from timolol to dorzolamide/timolol improves autoregulation in OAG patients significantly, whereas brimonidine/timolol does not [152].…”

Vitreous and Aqueous Concentrations of Brimonidine Following Topical Application of Brimonidine Tartrate 0.1% Ophthalmic Solution in Humans

“…2 Moreover, brimonidine tartrate ophthalmic solution 0.15% significantly improves retinal vascular autoregulation in normal-tension glaucoma patients. 8 To confirm whether the concentration of brimonidine in the vitreous is enough to exhibit neuroprotection in the retina, quantitative measurement of the drug in ocular media has been carried out after the topical administration of brimonidine tartrate 0.2% and 0.15%. 9,10 Most of the brimonidine tartrate-administered eyes showed the concentration of more than 2 nM in the vitreous, which is known to activate neuroprotective a-2 receptors in animal retina.…”