Effect of broflanilide on the phytophagous mite Tetranychus urticae and the predatory mite Typhlodromips swirskii

Abstract

BACKGROUND Two‐spotted spider mite (TSSM), Tetranychus urticae Koch, is one of the most serious pests of agricultural crops. Broflanilide exhibits high lethality against various pests and has been marketed worldwide under the Vedira and Tenebenal brands in 2020. Nevertheless, little information has been reported about its effects on agricultural mites. RESULTS Broflanilide displayed higher toxicity to TSSM eggs (24 h LC50, 1.015 mg L−1) and adult females (24 h LC50, 2.062 mg L−1) than commercial acaricides, including cyflumetofen, bifenazate, and profenofos. In contrast, the adverse effects of broflanilide on the predatory mite, Typhlodromips swirskii Athias‐Henriot, was lower than those of fenpyroximate and abamectin. In the sublethal effect study, while adult females were treated with broflanilide, the number of eggs and longevity were reduced in LC10 and LC30 treatments; when eggs were treated with broflanilide, the egg duration and deutonymph duration were prolonged in LC30 treatment. A significant decrease in the total life span and duration and fecundity of adult females was observed in LC10 and LC30 treatments. Furthermore, the number of eggs per adult female was significantly reduced from 103.48 ± 3.69 in the control group to 69.42 ± 2.22 and 48.33 ± 1.75 in LC10 and LC30 treatments, respectively. In the greenhouse bioassay, broflanilide 5% suspension concentrate (MCI‐8007) showed excellent acaricidal activity to TSSM, with 99.22% corrected control, compared with the MCI‐8007 untreated group. CONCLUSION Our results indicated that broflanilide has a high acaricidal activity to TSSM and significant inhibition to fecundity of adult female, and could be considered as a potential alternative for TSSM management. © 2021 Society of Chemical Industry.

Toxicity and Sublethal Effects of Fluxametamide on the Key Biological Parameters and Life History Traits of Diamondback Moth Plutella xylostella (L.)

“…In addition, the non-significant increase in the mean fecundity of S. litura was observed at the sublethal concentrations of a meta-diamide insecticide broflanilide, but the exact reason has yet to be confirmed [53]. However, neither any positive effect nor insecticide hormoligosis was reported in the fecundity of broflanilide-treated Tetranychus urticae [59], and this substantiated the present results. Besides, the sublethal effects of spinosad [60] and spinetoram [23] on the pre-oviposition period of P. xylostella have been investigated.…”

VECTRON™ T500, a new broflanilide insecticide for indoor residual spraying, provides prolonged control of pyrethroid-resistant malaria vectors

“…Proportional data (exiting rate, blood-feeding, and mortality) were analysed using mixed effects logistic regression while adjusting for the effects of sleeper attractiveness to mosquitoes and clustering by day. Wild vector mosquito mortality was used to assess the non-inferiority of VECTRON TM T500 to Actellic® 300CS using a noninferiority margin of 0.7 as defined by the WHO [22]. Cone bioassay mortality was pooled for each treatment and substrate at each time point and compared against an 80% cut-off following WHO guidelines [29].…”

“…It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted October 16, 2022. ; https://doi.org/10.1101/2022.10.12.511866 doi: bioRxiv preprint (MCAG) has developed a new active ingredient, broflanilide, a meta-diamide insecticide with a novel mode of action, classified as a GABA-gated chloride channel allosteric modulator [16][17][18]. Earlier studies demonstrated its effectiveness against a wide range of insect pests [19][20][21] and since 2020, it has been marketed worldwide for control of agricultural pests [22].…”

Manufacturing Approaches of New Halogenated Agrochemicals

“…[57] The insecticide 84 demonstrates a broad-spectrum activity in different crops and can be used in professional pest management markets, e. g. for control of lepidoptera, coleoptera, termites, ants, cockroaches, flies and mites. [58] As proinsecticides [59] both 84 and 85 are metabolized probably by CYP 450 -mediated bioactivation to N-demethyl-broflanilide 84 a by cleavage of the N-methyl group (in case of 85 cleavage of the N-cyclopropylmethyl group), which act as non-competitive GABA receptor antagonists on a novel site in Drosophila RDL GABA-receptors (resistant-to-dieldrin, RDL). [60]…”