Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery

Abstract

ABSTRACT.Purpose: This study compared the post-cataract surgery anti-inflammatory effects of topical treatment with 0.1% bromfenac, 0.1% betamethasone or both on postoperative anterior chamber inflammation and corneal swelling. Methods: Seventy-two patients with no eye disease other than cataract were enrolled in a prospective, randomized study to undergo phacoemulsification combined with intraocular lens implantation. After cataract surgery, patients were randomized to treatment with bromfenac, betamethasone or both agents. Twenty-five eyes were assigned to bromfenac, 23 to betamethasone and 24 to the combined treatment group. Inflammatory reactions in the anterior chamber were measured with laser flare photometry preoperatively and at 1 and 3 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Intraocular pressure (IOP) and corneal thickness were measured at the same time-points. Best corrected visual acuity (BCVA) was measured preoperatively and at 2 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Specular microscope endothelial photography of the central region of the cornea was performed preoperatively and at 3 months after surgery. Results: There were no significant differences among the bromfenac, betamethasone and combined treatment groups in BCVA, IOP, aqueous flare or corneal thickness. Cystoid macular oedema was present in one eye treated with betamethasone. Conclusions: There were no significant differences in anti-inflammatory effects among the three treatments. These findings suggest that bromfenac is as effective as betamethasone in minimizing inflammatory reactions after cataract surgery.

Comparing the Efficacy Ofbromfenac 0.09% and Nepafenac 0.1% Post Cataract Surgery: A Prospective Evaluation

“…Previous versions of OCT have been found by some to not be as reliable as other methods in determining retinal thickness as it relates to CME [8]. Our findings seem to be consistent with others showing that OCT 3 is highly sensitive in diagnosing subclinical CME [7,[11][12][13]. In this study, CME was defined as foveal and central foveal thickness 2 SD outside the mean.…”

“…Miyanaga et al [12] reported that bromfenac is effective in minimizing inflammation after cataract surgery. Our study mirrored the findings by Lindstrom [6] and Miyanaga [12]. Our diabetic population was well controlled and the incidence of clinical CME was non-existent and only two were diagnosed subclinically.…”

Topical bromfenac for post-cataract extraction: A systematic review and pooled analysis

“…[26][27][28] Bromfenac ophthalmic solution has received FDA approval based upon the clearance of anterior chamber (AC) inflammation after cataract surgery. 6,7 Recently, Wang et al 29 and Sher et al 30 reported on the role of bromfenac in managing ocular pain and discomfort following refractive surgery. The clinical benefits of bromfenac have been extensively discussed in several comparative studies including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, as well as postoperative inflammation.…”

“…4 Bromfenac, a highly potent inhibitor for both COX-1 and 2 isoforms, belongs to the NSAID class but exhibits unique characteristics 5 that enhances lipophilicity and facilitates its moving across the epithelial layers 5 and prolongs the duration of analgesic and anti-inflammatory effect. 6,7 These superior therapeutic benefits of bromfenac have led to its ophthalmic use especially for the pain and inflammation control after CE. [8][9][10] Oncedaily 11 dosing was previously approved in the USA and Japan and limiting the ocular exposure to bromfenac may result in decreased adverse events (AEs), which is important because, historically, ocular NSAID use has resulted in small numbers of corneal erosions or melts.…”

A Prospective, Open-label Study to Compare the Efficacy and the Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Post-Operative Inflammation after Cataract Extraction

“…In the earlier studies which were done, the topical NSAIDs like flurbiprofen ketorolac, bromofenac and diclofenac had been evaluated for their anti-inflammatory actions and the prevention of intraoperative miosis and cystoids macular oedema [15][16][17][18].…”