Effect of bronchoalveolar lavage on the clinical efficacy, inflammatory factors, and immune function in the treatment of refractory pneumonia in children

Pei, Minqing; Jiang, Ping; Wang, Tingting; Xia, Caifeng; Hou, Ruiying; Sun, Ai-ling; Zou, Hui

doi:10.21037/tp-21-89

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…BAL can improve pulmonary imaging of RMPP patients and shorten hospitalization time ( 20 , 28 ). However, some clinical studies have shown that BAL can significantly prolong the hospital stay and increase the total cost ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Zhang

Wang

et al. 2023

Front. Pediatr.

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BackgroundThe purpose of this study was to evaluate the efficacy and safety of BAL in treating MPP.MethodsFrom January 2013 to January 2019, 1,689 pediatric patients with MPP were analyzed retrospectively. Patients were subdivided into BAL group and non-BAL group according to whether they received BAL treatment within seven days after admission. The propensity score matching method matched patients' baseline characteristics (1:1). The primary outcomes were hospital stays and the cure rate. Secondary outcomes included mortality, co-infection, repeat hospitalization within 30 days, and total cost of treatment.ResultsAfter matching, 524 patients (BAL: 262; control: 262) were recorded. The BAL group had significantly shorter hospital stays (OR: 0.5, 95% CI: 0.4–0.7). Meanwhile, BAL did not significantly modify the cost, co-infection rate, and mortality. In subgroup analyses, the group with BAL intervention within three days had a significantly shorter hospital stay (OR: 0.4, 95% CI: 0.3–0.5) compared with the group with BAL intervention three days after admission.ConclusionsEarly BAL intervention is a better treatment than conventional drug therapy alone, and no significant complications were seen in this study. BAL intervention has an excellent clinical benefit. The earlier the intervention, the better the effect.

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Section: Discussionmentioning

confidence: 99%

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Zhang

Wang

et al. 2023

Front. Pediatr.

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“…Based on our results, BAL did not reduce fever and wheezing time but shortened the coughing time. Minqing et al reported that BAL treatment could effectively shorten the fever remission time and hospital stay duration and provide cough relief ( 9 ). The inconsistency in the literature may be attributed to the difference in the inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of bronchoalveolar lavage in the treatment of small airway diseases in children

Zhou,

Peng,

Cao

et al. 2024

Front. Pediatr.

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ObjectiveThis study aimed to evaluate the efficacy of bronchoalveolar lavage (BAL) in the treatment of children with small airway diseases.MethodsChildren [n = 112; boys: 76, girls: 36 (ratio 2.1:1); age range: 1 month–10 years; median age: 12 months] with small airway diseases diagnosed by high-resolution computed tomography (HRCT) were enrolled in this study. The patients were assigned to either the BAL group (BAL and conventional therapy) or the control group (conventional therapy only). The duration of cough, fever, wheezing, hospitalization duration, disease course before admission, treatment cost, HRCT recovery time, and re-hospitalization rate were compared between the two groups.ResultsThe median disease course before admission of the BAL group patients was longer than that of the controls (p = 0.006). The duration of cough and wheezing in the BAL group was significantly longer than that in the control group (p = 0.012 and p = 0.001, respectively). The recovery time of cough, the re-hospitalization rate, and the total expenditure incurred for the BAL group were lower than those for the control group (p = 0.027, p = 0.026, and p = 0.000, respectively). At 2 months after discharge, the small airway lesions were found to be absorbed in 86.2% of BAL group patients vs. 64.1% of control group patients. At 6 months after discharge, the lesions were not fully absorbed in 3.4% of the BAL group patients compared to 20.5% in the control group patients.ConclusionBAL is suitable for patients with a long disease course before admission, a long duration of coughing, and recurrent wheezing. BAL treatment of small airway diseases in children can promote the disappearance of clinical symptoms, accelerate the improvement of imaging, reduce the rate of re-hospitalization, and reduce the cost of treatment.

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“…Some previous studies have already demonstrated that B-ACT is significantly beneficial for children with SP [13,14], but its specific effectiveness for adults with SP has long been debated. Our analysis showed that B-ACT could improve some important laboratory results including some inflammatory factors (CRP and PCT), routine blood parameters (WBC# and N%) and blood gas analysis (PO 2 and SO 2 ).…”

Section: Discussionmentioning

confidence: 99%

Brochoscopic Airway Clearance Therapy vs. Conventional Sputum Aspiration: The Future of Flexible Brochoscopes in Intensive Care Units?

Yao,

Liu,

et al. 2023

Diagnostics

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(1) Background: The aim of our study is to investigate the effectiveness of bronchoscopic airway clearance therapy (B-ACT) on severe pneumonia (SP) patients with invasive mechanical ventilation (IMV) in the intensive care unit (ICU). (2) Methods: Our study retrospectively enrolled 49 patients with sputum aspiration and 99 patients with B-ACT, and the latter were divided into the ≤once every 3 days group (n = 50) and >once every 3 days group (n = 49). (3) Results: We found most laboratory blood results were significantly improved in the B-ACT group as compared with those in sputum aspiration group (p < 0.05). Patients in the B-ACT group and those in ≤once every 3 days group also had significantly better survival to hospital discharge than those in their counterpart groups (Logrank p < 0.001). In patients with cardiopulmonary diseases or positive cultures for bacteria, the B-ACT group and those in the ≤once every 3 days group had significantly better survival outcomes to discharge than those in their counterpart groups (Logrank p < 0.001). B-ACT and the average frequency of ≤once every 3 days had significantly better impact on survival outcomes than their counterpart groups (HR: 0.444, 95% CI: 0.238–0.829, p = 0.011; HR: 0.285, 95% CI: 0163–0.498, p < 0.001). (4) Conclusions: In the future, flexible bronchoscopes may paly an important role in ACT for SP patients with IMV.

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Effect of bronchoalveolar lavage on the clinical efficacy, inflammatory factors, and immune function in the treatment of refractory pneumonia in children

Cited by 6 publications

References 20 publications

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Clinical efficacy of bronchoalveolar lavage in the treatment of small airway diseases in children

Brochoscopic Airway Clearance Therapy vs. Conventional Sputum Aspiration: The Future of Flexible Brochoscopes in Intensive Care Units?

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