Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

Bhatti, Maria; Ayton, Sarah L; Michail, Olga; Gollop, Nicholas D.; Ryding, Alisdair; Rushworth, Stuart A.; Bowles, Kristian M.; Geisler, Tobias; Flather, Marcus

doi:10.1016/j.thromres.2019.04.024

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…MMP-9 is an enzyme analog that damages the elastic membrane of blood vessels and is closely related to atherosclerotic plaque and vascular reconstruction [ 24 ]. hs-CRP is an indicator of inflammatory state, and the level of hs-CRP can change with the characteristics of coronary plaque, which is a predictor of coronary disease-related mortality [ 25 ]. FIB can promote the proliferation of vascular smooth muscle cells and the formation of atherosclerotic plaques, which is an indicator of thrombosis [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Yang

Zhang

2022

BioMed Research International

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Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C ( p < 0.05 ). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading ( p < 0.001 ). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated ( p < 0.001 ). Conclusion. The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Yang

Zhang

2022

BioMed Research International

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“…On the one hand, the dosage of Ibrutinib can be reduced. On the other hand, the indications and dosage of antithrombotic drugs are also important, and platelet transfusion should be considered even if there is no thrombocytopenia in the case of severe bleeding [ 26 ]. Salem [ 27 ] noted that Ibrutinib can induce cardiovascular events, and cardiovascular toxicity is the leading cause of death.…”

Section: Discussionmentioning

confidence: 99%

Ibrutinib in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Retrospective Study

Ren

Zhang

et al. 2021

Indian J Hematol Blood Transfus

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Limited treatment options are available for relapsed or refractory diffuse large B cell lymphoma (RR DLBCL). Few clinical studies have reported the use of Ibrutinib, a covalent Bruton Tyrosine kinase (BTK) inhibitor, in RR DLBCL. There are relatively few clinical studies about Ibrutinib in RR DLBCL now. We retrospectively investigated the safety and efficacy of Ibrutinib (alone or in combination with other drugs) in patients with RR DLBCL. We reviewed the medical records of 40 RR DLBCL patients who received Ibrutinib alone or in combination with other drugs in our hospital from June 2018 to August 2020. The objective response rate (ORR) of RR DLBCL patients on Ibrutinib was 22.5%. The median progression free survival time (PFS) was 13.0 months (95% CI 8.914–17.086), and the median overall survival time (OS) was 15.0 months (95% CI 11.931–18.089). Rash (25.0%) and fatigue (25.0%) were the most common adverse reactions in this study. The application of Ibrutinib to patients with RR DLBCL has good short-term efficacy, and the adverse reactions are well tolerated. Combined treatment of Ibrutinib with other drugs has been found to more effective than Ibrutinib therapy alone.

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“…In addition, a previous study has shown that isobavachalcone inhibits platelet aggregation induced by arachidonic acid, collagen, and platelet activating factor in rabbits [52]. As we all know, platelet aggregation is closely related to myocardial infarction and stroke [53,54].…”

Section: Cardiovascular Function Regulationmentioning

confidence: 94%

Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

Zhou

Zhu

Yuan

et al. 2020

Oxidative Medicine and Cellular Longevity

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During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.

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Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

Cited by 7 publications

References 34 publications

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Ibrutinib in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Retrospective Study

Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

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