Effect of Bufei granule on stable chronic obstructive pulmonary disease: a randomized, double blinded, placebo-controlled, and multicenter clinical study

Guo, Sijia; Sun, Zhen; En-shun, Liu; Feng, Jing; Fu, Min; Li, Yuechuan; Wu, Qi

doi:10.1016/s0254-6272(15)30043-1

Cited by 18 publications

(48 citation statements)

References 19 publications

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“…The primary endpoints for the present study were the clinical symptoms and the quality of life. The clinical efficacy was evaluated as previously reported (21). When clini cal symptoms of COPD disappeared and total TCM syndrome scores reduced by 95-100%, the treatment was considered as clinical control and defined as I.…”

Section: Methodsmentioning

confidence: 99%

“…If clinical symptoms did not improve or even deteriorate, and total TCM syndrome scores decreased by <30%, the treatment was regarded as ineffective and defined as IV. The acute exacerbation of COPD was diagnosed based on the diagnostic criteria by GOLD and the Chinese Society of Respiratory Diseases (2007 version) (21). The frequency and duration of acute exacerbation during the period of treatment were recorded for 12 weeks as previously described (19).…”

Section: Methodsmentioning

confidence: 99%

“…For evaluation of pulmonary function, forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), FEV1/predicted value, FEV1/FVC, mean maximum expiratory flow (MMEF) 75/25 and peak expiratory flow (PEF) were also tested (21).…”

Section: Pulmonary Function and 6-min Walking Distance (6mwd)mentioning

confidence: 99%

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Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

Qian

Fan

2017

Experimental and Therapeutic Medicine

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

Qian

Fan

2017

Experimental and Therapeutic Medicine

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“…Whilst this particular study reported no improvements in lung function when the plant-based medicine was added to conventional COPD treatment other researchers have seen marked improvement in lung function following the use of a plant-based medicine. Guo et al [49] conducted a randomised, double-blinded, placebo-controlled study investigating the effects of Bu-Fei granules on the frequency of COPD exacerbations along with lung function and serum inflammatory mediator levels. BuFei granules have been historically used in traditional Chinese medicine to enhance lung immune functions.…”

Section: Plant-based Therapies For Copdmentioning

confidence: 99%

“…Table S2. A summary of some of the human clinical trials published in the last 10 years fitting the search terms herbal/plant/phytomedicine and COPD in the NCBI database [47][48][49][66][67][68][69][70][71][72][73][74][75][76]. Table S3.…”

Section: Additional Filementioning

confidence: 99%

Herbal treatment in asthma and COPD – current evidence

2015

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Asthma and COPD are chronic inflammatory respiratory diseases affecting millions of people worldwide and increasing in prevalence. Current treatment options for both conditions aim to alleviate symptoms, improve patient quality of life and prevent disease progression rather than cure the underlying condition itself. Treatments available to patients include anti-inflammatory therapies, bronchodilators and inhaled corticosteroids. While these treatments have been deemed effective at alleviating disease symptoms and exacerbations they are not without their limitations. Overuse of some therapies can induce adverse effects in some patients such as increased risk of developing pneumonia and cardiac co-morbidities. Along with the risks of side effects not all patients will respond to the current treatment options and therefore there is an unmet need for additional or alternative treatments for asthma and COPD. One such area showing good promise in providing an alternative or add-on therapy is that of phytomedicine. Phytomedicine is defined as a plant-based traditional medical practice that uses various plant materials in modalities considered both preventive and therapeutic. This review focuses on recent human clinical trials using plant-based medicines for the treatment of asthma and COPD.

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Bioactivity‐based ultra‐performance liquid chromatography‐coupled quadrupole time‐of‐flight mass spectrometry for NF‐κB inhibitors identification in Chinese Medicinal Preparation Bufei Granule

Cui

Zhou

et al. 2016

Biomedical Chromatography

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Traditional Chinese medicine (TCM) preparations have become effective treatments for many diseases. However, their active ingredients are still uncertain and difficult to identify. In this study, we propose a strategy that integrates ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) and bioactive (NF-κB inhibitor) luciferase reporter assay systems for the rapid determination of various anti-inflammatory compounds of TCM preparations. In this way, Bufei Granule (BFG), a TCM preparation used for the clinical therapy of asthma, was analyzed by the two ways of component identification and activity detection. Potential anti-inflammatory constituents were screened by NF-κB activity assay systems and simultaneously identified according to the mass spectrometry data. Three structural types of NF-κB inhibitors (caffeic acid derivatives, flavonoids and Pentacyclic triterpenes) were characterized. Further cytokine detection confirmed the anti-inflammatory effects of the potential NF-κB inhibitors. Compared with conventional chromatographic separation and inhibitory activity detection, integrating UPLC/Q-TOF-MS identification and virtual validation was more convenient and more reliable. This strategy clearly demonstrates that MS data-based fingerprinting is a meaningful tool not only in identifying constituents in complex matrix but also in directly screening for powerful trace ingredients in TCM preparations. Copyright © 2016 John Wiley & Sons, Ltd.

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Effect of Bufei granule on stable chronic obstructive pulmonary disease: a randomized, double blinded, placebo-controlled, and multicenter clinical study

Cited by 18 publications

References 19 publications

Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

Herbal treatment in asthma and COPD – current evidence

Bioactivity‐based ultra‐performance liquid chromatography‐coupled quadrupole time‐of‐flight mass spectrometry for NF‐κB inhibitors identification in Chinese Medicinal Preparation Bufei Granule

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