Effect of Buffered 4% Lidocaine on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study

Buffered 4% Articaine as a Primary Buccal Infiltration of the Mandibular First Molar: A Prospective, Randomized, Double-blind Study

“…1). Although buffering lidocaine has been shown by Al-Sultan et al (8,9) to improve efficacy for extractions and periapical surgery, Whitcomb et al (7) did not find an increased efficacy with buffered lidocaine for asymptomatic subjects with the IAN block nor did Saatchi et al (11) or Schellenberg et al (12) find a significant difference for IAN blocks in patients presenting with symptomatic irreversible pulpitis. Additionally, Balasco et al (10) did not find decreased pain for an incision and drainage procedure with a buffered lidocaine formulation.…”

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,10,12,16,21,22). Buffering the formulation increased the pH of the anesthetic formulation (from 4.76-7.59) but did not result in less pain during solution deposition.…”

“…However, Whitcomb et al (7) did not find an increased efficacy with buffered lidocaine for the inferior alveolar nerve (IAN) block nor did Balasco et al (10) find decreased pain for an incision and drainage procedure with a buffered formulation. Recently, Saatchi et al (11) and Schellenberg et al (12) evaluated buffered 2% lidocaine with 1:80,000 epinephrine formulation and buffered 4% lidocaine with 1:100,000 epinephrine formulation, respectively, for IAN blocks in patients presenting with symptomatic irreversible pulpitis. They both concluded that buffering did not statistically improve anesthetic success.…”

A Comparison of Different Volumes of Articaine for Inferior Alveolar Nerve Block for Molar Teeth with Symptomatic Irreversible Pulpitis

“…A major concern for dentists during root canal treatment is to provide profound anesthesia during the procedure (2). Numerous studies have been performed to assess methods to overcome pain and discomfort during root canal treatment using various techniques, equipment, and anesthetic solutions (3)(4)(5)(6)(7)(8).…”

Efficacy of a Buffered 4% Lidocaine Formulation for Incision and Drainage: A Prospective, Randomized, Double-blind Study

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (12,13,(20)(21)(22), whereas others have not shown a decrease (1,2,14,16,23,24). Most of the previous medical and dental studies evaluated injections into healthy, noninflamed tissue sites.…”